PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26519986-9 2016 Inhibitors (PD98059, mevastatin and genistein) of specific sites along the Ras/Raf/MEK/ERK signaling pathway, blocked the phosphorylation and concomitantly inhibited 5alphaP-induced stimulation of cell proliferation and detachment. mevastatin 21-31 mitogen-activated protein kinase 1 Homo sapiens 87-90 15786722-0 2005 Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK. mevastatin 0-10 mitogen-activated protein kinase 1 Homo sapiens 85-88 15786722-7 2005 When we examined the survival signals at the time of apoptotic induction, we also observed that the administration of mevastatin had caused a remarkable decrease in the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). mevastatin 118-128 mitogen-activated protein kinase 1 Homo sapiens 188-229 15786722-11 2005 These results suggested that mevastatin induced apoptosis when it inhibited GGPP biosynthesis and consequently decreased the level of phosphorylated ERK, which was a survival signal; moreover, at that time, there was no influence on NF-kappaB, Akt, p38, and Bcl-2. mevastatin 29-39 mitogen-activated protein kinase 1 Homo sapiens 149-152 15786722-11 2005 These results suggested that mevastatin induced apoptosis when it inhibited GGPP biosynthesis and consequently decreased the level of phosphorylated ERK, which was a survival signal; moreover, at that time, there was no influence on NF-kappaB, Akt, p38, and Bcl-2. mevastatin 29-39 mitogen-activated protein kinase 1 Homo sapiens 249-252