PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17640631-10 2007 Also mevastatin induced the accumulation of unprenylated Rap1A, but it did not induce p38 phosphorylation. mevastatin 5-15 RAP1A, member of RAS oncogene family Homo sapiens 57-62 12403272-0 2002 Mevastatin, an inhibitor of HMG-CoA reductase, induces apoptosis, differentiation and Rap1 expression in HL-60 cells. mevastatin 0-10 RAP1A, member of RAS oncogene family Homo sapiens 86-90 12403272-12 2002 These results suggest that mevastatin-induced apoptosis of HL-60 cells might be caused indirectly by activation of the caspase cascade through the modulation of mitochondrial functions and that some relationship between a certain small GTPase molecule, such as Rap1, and mevastatin-induced apoptosis may exist. mevastatin 27-37 RAP1A, member of RAS oncogene family Homo sapiens 261-265 12403272-12 2002 These results suggest that mevastatin-induced apoptosis of HL-60 cells might be caused indirectly by activation of the caspase cascade through the modulation of mitochondrial functions and that some relationship between a certain small GTPase molecule, such as Rap1, and mevastatin-induced apoptosis may exist. mevastatin 271-281 RAP1A, member of RAS oncogene family Homo sapiens 261-265 12403272-9 2002 Furthermore, mevastatin decreased the amount of an isoprenylated membrane bound Rap1 small GTPase concomitant with an increase in cytosolic Rap1 which occurred before apoptosis and differentiation. mevastatin 13-23 RAP1A, member of RAS oncogene family Homo sapiens 80-84 12403272-9 2002 Furthermore, mevastatin decreased the amount of an isoprenylated membrane bound Rap1 small GTPase concomitant with an increase in cytosolic Rap1 which occurred before apoptosis and differentiation. mevastatin 13-23 RAP1A, member of RAS oncogene family Homo sapiens 140-144