PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2229078-17	1990	The reticulocyte heme-controlled repressor phosphorylates the alpha-subunit of eIF-2 from both sea urchins and rabbit reticulocytes.	Heme	17-21	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	79-84	
16109458-0	2005	Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase.	Heme	56-60	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	71-76	
2229078-20	1990	Since both heme controlled repressor and casein kinase II phosphorylate the alpha-subunit of sea urchin eIF-2 caution should be exercised when interpreting the significance of eIF-2(alpha) phosphorylation in sea urchins.	Heme	11-15	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	104-109	
6798420-4	1981	This kinase has been shown to be distinct from the heme regulated enzyme that phosphorylates the small subunit of eIF-2.	Heme	51-55	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	114-119	
6551177-6	1983	However, if the eIF-2 has previously been phosphorylated by the reticulocyte heme-controlled repressor, the 40S subunit induced inhibition cannot be reversed by elimination of free GDP.	Heme	77-81	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	16-21	
6551177-7	1983	The instability of initiation complexes containing eIF-2, together with the impairment of guanine nucleotide exchange after phosphorylation of eIF-2 [Clemens, M.J., Pain, V.M., Wong, S.-T., & Henshaw, E. C. (1982) Nature (London) 296, 93-95], may be an important aspect of the mechanism of the inhibition of translation by the heme-controlled repressor.	Heme	331-335	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	143-148	
2991909-3	1985	Heme also regulates protein synthesis in immature erythroid cells through its effects on phosphorylation of the initiation factor eIF-2.	Heme	0-4	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	130-135	
4092499-2	1985	The absence of heme leads to the activation of a nucleotide-independent protein kinase that phosphorylates the alpha subunit of the chain initiation factor eIF-2.	Heme	15-19	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	156-161	
6417655-3	1983	The inhibition by Ca2+ or phospholipid is accompanied by phosphorylation of the 38-kilodalton subunit of the eukaryotic initiation factor 2 (eIF-2) and the 90-kilodalton band of the heme-controlled translational inhibitor (HCI) and can be reversed by high concentrations of eIF-2 or GTP.	Heme	182-186	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	274-279	
249315-4	1978	Phosphorylation of the 37,000-dalton eIF2 subunit by the heme-controlled translational repressor does not alter the ability of mRNA to produce subunit dissociation of eIF2.	Heme	57-61	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	37-41