PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26067085-8 2015 CONCLUSION: By exporting the excess of de novo synthesized heme from intestinal cells, FLVCR1a participates in the control of intestinal mucosa homeostasis. Heme 59-63 FLVCR heme transporter 1 Homo sapiens 87-93 28766925-7 2017 This indicates that the homozygous p.Pro221Ser FLVCR1 variation compromises the ability of FLVCR1a to export heme leading to enhanced susceptibility to programmed cell death. Heme 109-113 FLVCR heme transporter 1 Homo sapiens 47-53 28766925-8 2017 Our study demonstrates the existence of a phenotypic continuum among the discrete disorders previously linked to FLVCR1 mutations, and suggests that the related alteration of heme metabolism may lead to the degeneration of specific neuronal cell populations. Heme 175-179 FLVCR heme transporter 1 Homo sapiens 113-119 27923065-5 2016 Using next generation sequencing in patients with congenital loss of pain perception, we here identify bi-allelic mutations in the FLVCR1 (Feline Leukemia Virus subgroup C Receptor 1) gene, which encodes a broadly expressed heme exporter. Heme 224-228 FLVCR heme transporter 1 Homo sapiens 131-137 27923065-6 2016 Different FLVCR1 isoforms control the size of the cytosolic heme pool required to sustain metabolic activity of different cell types. Heme 60-64 FLVCR heme transporter 1 Homo sapiens 10-16 27923065-8 2016 Using fibroblasts and lymphoblastoid cell lines from patients with sensory neurodegeneration, we here show that the FLVCR1-mutations reduce heme export activity, enhance oxidative stress and increase sensitivity to programmed cell death. Heme 140-144 FLVCR heme transporter 1 Homo sapiens 116-122 31408049-4 2019 FLVCR1 gene encodes for 2 heme export proteins, FLVCR1a (plasma membrane) and FLVCR1b (mitochondria), crucially involved in the regulation of cellular heme homeostasis. Heme 26-30 FLVCR heme transporter 1 Homo sapiens 0-6 31408049-4 2019 FLVCR1 gene encodes for 2 heme export proteins, FLVCR1a (plasma membrane) and FLVCR1b (mitochondria), crucially involved in the regulation of cellular heme homeostasis. Heme 151-155 FLVCR heme transporter 1 Homo sapiens 0-6 31408049-9 2019 The identification of novel FLVCR1 mutations in HSAN reinforces the crucial role of heme in sensory neuron maintenance and pain perception. Heme 84-88 FLVCR heme transporter 1 Homo sapiens 28-34 31408049-10 2019 Moreover, our in vitro findings demonstrate that heme export is not completely lost in HSAN patients, thus suggesting the possibility to improve FLVCR1 expression/activity for therapeutic purposes. Heme 49-53 FLVCR heme transporter 1 Homo sapiens 145-151 30530752-4 2019 Deletion of Flvcr1 results in high levels of intracellular heme, allowing us to identify heme-regulated circuitry. Heme 59-63 FLVCR heme transporter 1 Homo sapiens 12-18 30530752-4 2019 Deletion of Flvcr1 results in high levels of intracellular heme, allowing us to identify heme-regulated circuitry. Heme 89-93 FLVCR heme transporter 1 Homo sapiens 12-18 29192808-1 2018 FLVCR1 (feline leukemia virus subgroup c receptor 1) is a transmembrane protein involved in the trafficking of intracellular heme. Heme 125-129 FLVCR heme transporter 1 Homo sapiens 0-6 26058344-6 2016 FLVCR1 gene codes for two proteins: the plasma membrane heme exporter FLVCR1a and the mitochondrial heme exporter FLVCR1b. Heme 56-60 FLVCR heme transporter 1 Homo sapiens 0-6 26058344-6 2016 FLVCR1 gene codes for two proteins: the plasma membrane heme exporter FLVCR1a and the mitochondrial heme exporter FLVCR1b. Heme 100-104 FLVCR heme transporter 1 Homo sapiens 0-6 26058344-7 2016 The coordinated expression of both FLVCR1 isoforms regulates an intracellular heme pool, necessary for proper expansion and differentiation of erythroid precursors. Heme 78-82 FLVCR heme transporter 1 Homo sapiens 35-41 25795718-0 2015 The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Heme 4-8 FLVCR heme transporter 1 Homo sapiens 18-24 25795718-1 2015 Feline leukemia virus subgroup C receptor 1 (Flvcr1) encodes two heme exporters: FLVCR1a, which localizes to the plasma membrane, and FLVCR1b, which localizes to mitochondria. Heme 65-69 FLVCR heme transporter 1 Homo sapiens 0-43 25795718-1 2015 Feline leukemia virus subgroup C receptor 1 (Flvcr1) encodes two heme exporters: FLVCR1a, which localizes to the plasma membrane, and FLVCR1b, which localizes to mitochondria. Heme 65-69 FLVCR heme transporter 1 Homo sapiens 45-51 25795718-4 2015 FLVCR1a-down-regulated K562 cells have defective proliferation, enhanced differentiation, and heme loading in the cytosol, while FLVCR1a/1b-deficient K562 cells show impairment in both proliferation and differentiation, and accumulate heme in mitochondria. Heme 94-98 FLVCR heme transporter 1 Homo sapiens 0-6 25795718-4 2015 FLVCR1a-down-regulated K562 cells have defective proliferation, enhanced differentiation, and heme loading in the cytosol, while FLVCR1a/1b-deficient K562 cells show impairment in both proliferation and differentiation, and accumulate heme in mitochondria. Heme 235-239 FLVCR heme transporter 1 Homo sapiens 0-6 25582857-6 2015 These studies identify a novel and unexpected role for FLVCR, a major facilitator superfamily metabolite transporter, in T cell development and suggest that heme metabolism is particularly important in the T lineage. Heme 157-161 FLVCR heme transporter 1 Homo sapiens 55-60 23506900-5 2013 FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Heme 69-73 FLVCR heme transporter 1 Homo sapiens 31-37 24576667-2 2014 The Feline Leukemia Virus, subgroup C, Receptor 1 (Flvcr1) gene encodes for two isoforms, Flvcr1a and 1b, involved in the export of heme out of the cell and of mitochondria respectively. Heme 132-136 FLVCR heme transporter 1 Homo sapiens 51-57 24576667-7 2014 The inclusion of the Flvcr1 gene in the group of HIF2alpha-responsive genes strengthens its role in hypoxia-stimulated processes like erythropoiesis, vasculogenesis and heme absorption. Heme 169-173 FLVCR heme transporter 1 Homo sapiens 21-27 24021674-3 2013 One mechanism is through active heme export by the group C feline leukemia virus receptor (FLVCR). Heme 32-36 FLVCR heme transporter 1 Homo sapiens 91-96 22483575-0 2012 Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity. Heme 94-98 FLVCR heme transporter 1 Homo sapiens 13-19 22483575-1 2012 The feline leukemia virus subgroup C receptor 1 (FLVCR1) is a heme exporter that maintains the intracellular heme concentration. Heme 62-66 FLVCR heme transporter 1 Homo sapiens 49-55 22483575-1 2012 The feline leukemia virus subgroup C receptor 1 (FLVCR1) is a heme exporter that maintains the intracellular heme concentration. Heme 109-113 FLVCR heme transporter 1 Homo sapiens 49-55 22483575-4 2012 In this study, we analyzed the function of FLVCR1 mutants by using a fluorescent heme analog as a transporter substrate, and found that all 4 FLVCR1 mutants lost their heme export activity. Heme 81-85 FLVCR heme transporter 1 Homo sapiens 43-49 22483575-4 2012 In this study, we analyzed the function of FLVCR1 mutants by using a fluorescent heme analog as a transporter substrate, and found that all 4 FLVCR1 mutants lost their heme export activity. Heme 168-172 FLVCR heme transporter 1 Homo sapiens 43-49 22483575-4 2012 In this study, we analyzed the function of FLVCR1 mutants by using a fluorescent heme analog as a transporter substrate, and found that all 4 FLVCR1 mutants lost their heme export activity. Heme 168-172 FLVCR heme transporter 1 Homo sapiens 142-148 22483575-9 2012 Based on these results, we propose that FLVCR1 mutants failed to fold properly in the ER, were rapidly degraded in the lysosomes, and therefore, could not export heme out of cells. Heme 162-166 FLVCR heme transporter 1 Homo sapiens 40-46 22483575-10 2012 Thus, accumulation of heme in FLVCR1-mutant cells could cause cellular toxicity. Heme 22-26 FLVCR heme transporter 1 Homo sapiens 30-36 21238504-5 2011 Here we review aspects of heme metabolism and discuss our current understanding of heme transporters, with emphasis on the function of the cell-surface heme exporter, FLVCR. Heme 26-30 FLVCR heme transporter 1 Homo sapiens 167-172 21238504-5 2011 Here we review aspects of heme metabolism and discuss our current understanding of heme transporters, with emphasis on the function of the cell-surface heme exporter, FLVCR. Heme 83-87 FLVCR heme transporter 1 Homo sapiens 167-172 17368550-8 2007 In this review, we focus on the roles of the recently identified heme/porphyrin transport proteins heme carrier protein 1 (HCP1), FLVCR, Abcg2 and Abcb6 and discuss how these transporters contribute to intracellular heme and porphyrin homeostasis. Heme 65-69 FLVCR heme transporter 1 Homo sapiens 130-135 20610401-1 2010 The feline leukemia virus subgroup C receptor (FLVCR) is a heme export protein that is required for proerythroblast survival and facilitates macrophage heme iron recycling. Heme 59-63 FLVCR heme transporter 1 Homo sapiens 47-52 20454576-9 2010 Herein, we review the known roles of RPS19 and FLVCR1 in ribosome function and heme metabolism respectively, and discuss how the deficiency of a ribosomal protein or of a heme exporter may result in the same phenotype. Heme 79-83 FLVCR heme transporter 1 Homo sapiens 47-53 20454576-9 2010 Herein, we review the known roles of RPS19 and FLVCR1 in ribosome function and heme metabolism respectively, and discuss how the deficiency of a ribosomal protein or of a heme exporter may result in the same phenotype. Heme 171-175 FLVCR heme transporter 1 Homo sapiens 47-53 20610401-6 2010 However, FLVCR has a narrow substrate range because unconjugated bilirubin, the primary breakdown product of heme, was not transported. Heme 109-113 FLVCR heme transporter 1 Homo sapiens 9-14 18258918-4 2008 We previously demonstrated that the feline leukemia virus, subgroup C, receptor (FLVCR) exports cytoplasmic heme. Heme 108-112 FLVCR heme transporter 1 Homo sapiens 81-86 18258918-7 2008 We further demonstrate that FLVCR mediates heme export from macrophages that ingest senescent red cells and regulates hepatic iron. Heme 43-47 FLVCR heme transporter 1 Homo sapiens 28-33 15369674-2 2004 In this report, we demonstrate that human FLVCR exports cytoplasmic heme and hypothesize that human FLVCR is required on developing erythroid cells to protect them from heme toxicity. Heme 68-72 FLVCR heme transporter 1 Homo sapiens 42-47 15369674-2 2004 In this report, we demonstrate that human FLVCR exports cytoplasmic heme and hypothesize that human FLVCR is required on developing erythroid cells to protect them from heme toxicity. Heme 68-72 FLVCR heme transporter 1 Homo sapiens 100-105 15369674-3 2004 Inhibition of FLVCR in K562 cells decreases heme export, impairs their erythroid maturation and leads to apoptosis. Heme 44-48 FLVCR heme transporter 1 Homo sapiens 14-19 15369674-4 2004 FLVCR is upregulated on CFU-E, indicating that heme export is important in primary cells at this stage. Heme 47-51 FLVCR heme transporter 1 Homo sapiens 0-5 15369674-5 2004 Studies of FLVCR expression in cell lines suggest this exporter also impacts heme trafficking in intestine and liver. Heme 77-81 FLVCR heme transporter 1 Homo sapiens 11-16