PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16772725-4 2006 In this study, we investigated the effect of procaterol, the synthetic beta2-adrenoceptor agonist widely used as bronchodilators in asthma, on the PPARgamma expression in eosinophils. Procaterol 45-55 adrenoceptor beta 2 Homo sapiens 71-89 21490253-6 2011 By using cultured HEK293 cells transfected with zebrafish betaARs, we demonstrated that stimulation with adrenaline or procaterol (a beta2AR agonist) resulted in an increase in intracellular cAMP levels in cells expressing any of the three zebrafish betaARs. Procaterol 119-129 adrenoceptor beta 2 Homo sapiens 133-140 20672293-1 2010 Procaterol is a beta2-adrenoceptor agonist used as a bronchodilator for the treatment of asthma; it also possesses an anti-inflammatory property. Procaterol 0-10 adrenoceptor beta 2 Homo sapiens 16-34 20672293-10 2010 In conclusion, procaterol could inhibit Th2-related chemokines production in human monocytes and bronchial epithelial cells, an effect that may be mediated through not only the NF-kappaB, p38, and JNK-MAPK pathways, but also the beta2-adrenoceptor-cAMP pathway. Procaterol 15-25 adrenoceptor beta 2 Homo sapiens 229-247 16772725-7 2006 We observed that PPARgamma was constitutively expressed by EoL-1 and the purified eosinophils and that the therapeutic concentration (10(-9)M) of procaterol markedly enhanced PPARgamma protein expression, which was reversed by the selective beta2-adrenoceptor antagonist ICI-118551. Procaterol 146-156 adrenoceptor beta 2 Homo sapiens 241-259 12428391-4 2002 The present study showed that a single inhalation of procaterol has a varying bronchodilator effect on healthy adults, depending on the genotype of beta 2 adrenoceptor polymorphism at codon 16. Procaterol 53-63 adrenoceptor beta 2 Homo sapiens 148-167 16147906-2 2005 We examined whether the beta2-adrenoceptor agonists, procaterol and fenoterol, induce human Per1 mRNA expression in human bronchial epithelium. Procaterol 53-63 adrenoceptor beta 2 Homo sapiens 24-42 15311061-4 2004 All beta2-adrenoceptor agonists tested (salbutamol, procaterol and terbutaline) attenuated the KCl induced contraction. Procaterol 52-62 adrenoceptor beta 2 Homo sapiens 4-22 15069780-8 2004 The present study showed inhalation of procaterol and oxitropium had a differential bronchodilator effect in healthy women, depending on their genotype of beta 2-adrenoceptor polymorphism at codon 16. Procaterol 39-49 adrenoceptor beta 2 Homo sapiens 155-174 10992416-5 2000 RESULTS: 1) Isoprenaline and procaterol (a beta2-AR agonist) concentration-dependently suppressed both spontaneous and KCl-induced contractions of the human ureter. Procaterol 29-39 adrenoceptor beta 2 Homo sapiens 43-51 12027071-6 2002 Inhibition by salbutamol or procaterol was completely reversed by either propranolol, a nonselective beta-adrenoceptor antagonist, or ICI-118551, a beta2-adrenoceptor-selective antagonist. Procaterol 28-38 adrenoceptor beta 2 Homo sapiens 148-166 7476903-5 1995 Thus, the beta 2-adrenoceptor agonists albuterol and procaterol partially (approximately 40%) suppressed TNF-alpha generation in a propranolol-sensitive manner. Procaterol 53-63 adrenoceptor beta 2 Homo sapiens 10-29 10601590-5 2000 In the NSCLC cell line, sensitivity to cisplatin was improved by treatment with procaterol, a selective beta2-adrenoceptor agonist. Procaterol 80-90 adrenoceptor beta 2 Homo sapiens 104-122 10531390-2 1999 The beta(1)/beta(2)-chimeric receptors showed the importance of the second and seventh transmembrane domains (TM2 and TM7) of the beta(2)AR for the binding of the beta(2)-selective agonists such as formoterol and procaterol. Procaterol 213-223 adrenoceptor beta 2 Homo sapiens 130-139 10614711-3 1999 Upon individual acute treatments with morphine and procaterol (a selective beta2-AR agonist), both the delta-OR and beta2-AR are coupled to differential modulation of cyclic AMP (cAMP) levels in accord with the classical second messenger response patterns to these agonists in the normal cellular settings of the receptors. Procaterol 51-61 adrenoceptor beta 2 Homo sapiens 75-83 10614711-3 1999 Upon individual acute treatments with morphine and procaterol (a selective beta2-AR agonist), both the delta-OR and beta2-AR are coupled to differential modulation of cyclic AMP (cAMP) levels in accord with the classical second messenger response patterns to these agonists in the normal cellular settings of the receptors. Procaterol 51-61 adrenoceptor beta 2 Homo sapiens 116-124 10614711-7 1999 In contrast to treatment with individual agonists, chronic dual agonist treatment suppresses procaterol-induced stimulation of ERK activity and stimulation of proliferation indicating that a cross-regulatory interaction occurs between the delta-OR and beta2-AR signalling systems in the cells under these conditions. Procaterol 93-103 adrenoceptor beta 2 Homo sapiens 252-260 8897441-5 1996 The beta 2-adrenoceptor agonists salbutamol and procaterol increased the levels of endogenous cAMP and diminished the concentration of proenkephalin mRNA indicating that the cultured fibroblasts possessed this beta-subtype. Procaterol 48-58 adrenoceptor beta 2 Homo sapiens 4-23 7544228-0 1995 Effect of procaterol, a beta 2-adrenoceptor agonist, on skin whealing response caused by inflammatory mediators in asthmatic children. Procaterol 10-20 adrenoceptor beta 2 Homo sapiens 24-43 7544228-3 1995 METHODS: We examined the effect of procaterol, a beta 2-adrenoceptor agonist, on skin whealing responses to histamine, platelet-activating factor (PAF), substance P, or bradykinin in eight asthmatic children in a double-blind, randomized, cross-over study. Procaterol 35-45 adrenoceptor beta 2 Homo sapiens 49-68 2900601-3 1988 In isolated, electrically driven strips of human right atria, isoproterenol increased contractile force through stimulation of both beta 1 and beta 2 adrenoceptors, while the selective beta 2-adrenoceptor agonist, procaterol, caused its positive inotropic effect predominantly through beta 2-adrenoceptor stimulation. Procaterol 214-224 adrenoceptor beta 2 Homo sapiens 185-204 1979509-8 1990 On isolated, electrically driven right atria the beta 1-adrenoceptor-mediated positive inotropic effect of noradrenaline was - even with beta 1-adrenoceptor number increased - not altered, while the beta 2-adrenoceptor-mediated effect of procaterol was markedly enhanced. Procaterol 238-248 adrenoceptor beta 2 Homo sapiens 199-218 1980074-3 1990 The beta 2- adrenoceptor mediated positive inotropic effect of procaterol, however, was markedly enhanced. Procaterol 63-73 adrenoceptor beta 2 Homo sapiens 4-24 2900601-3 1988 In isolated, electrically driven strips of human right atria, isoproterenol increased contractile force through stimulation of both beta 1 and beta 2 adrenoceptors, while the selective beta 2-adrenoceptor agonist, procaterol, caused its positive inotropic effect predominantly through beta 2-adrenoceptor stimulation. Procaterol 214-224 adrenoceptor beta 2 Homo sapiens 285-304 2994790-5 1985 Adrenaline (in the presence of rauwolscine), isoprenaline and the preferential beta 2-adrenoceptor agonist, procaterol, concentration-dependently increased the electrically evoked tritium overflow. Procaterol 108-118 adrenoceptor beta 2 Homo sapiens 79-98 2877955-1 1986 The duration of action of procaterol, a beta-2-adrenoceptor agonist with an entirely new chemical structure, was assessed, in comparison to that of salbutamol, by inhalation of 43 inhalation units of methacholine at time intervals of 1, 3, 5, 7, and 9 hours after intake of the drugs. Procaterol 26-36 adrenoceptor beta 2 Homo sapiens 40-59 2877955-4 1986 It is concluded that procaterol can be a good alternative beta-2-adrenoceptor agonist when the oral route is needed. Procaterol 21-31 adrenoceptor beta 2 Homo sapiens 58-77 2900473-3 1988 Adrenaline (in the presence of rauwolscine), isoprenaline and the preferential beta 2-adrenoceptor agonist procaterol concentration-dependently increased the electrically evoked tritium overflow. Procaterol 107-117 adrenoceptor beta 2 Homo sapiens 79-98 2946644-1 1986 The aim of the present study was to verify the effectiveness of procaterol, a recent and specific beta-2-adrenoceptor stimulant, in preventing exercise-induced asthma (EIA). Procaterol 64-74 adrenoceptor beta 2 Homo sapiens 98-117 87200-0 1979 Effect of a selective beta 2-adrenoceptor agonist, procaterol, on tissue cyclic AMP level. Procaterol 51-61 adrenoceptor beta 2 Homo sapiens 22-41 28489379-1 2017 By means of a formal structural hybridization of the antipsychotic drug aripiprazole and the heterocyclic catecholamine surrogates present in the beta2-adrenoceptor agonists procaterol and BI-167107 (4), we designed and synthesized a collection of novel hydroxy-substituted heteroarylpiperazines and heteroarylhomopiperazines with high dopamine D2 receptor (D2R) affinity. Procaterol 174-184 adrenoceptor beta 2 Homo sapiens 146-164 6152266-3 1984 Isoprenaline (beta 1- and beta 2-adrenoreceptor agonist) and procaterol (beta 2-adrenoreceptor agonist) increased the release, propranolol (beta 1- and beta 2-adrenoreceptor antagonist) reduced it, and prenalterol (beta 1-adrenoreceptor agonist) and atenolol (beta 1-adrenoreceptor antagonist) had no effect. Procaterol 61-71 adrenoceptor beta 2 Homo sapiens 73-94