PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22694660-8 2012 Isoproterenol enhanced the content of malondialdehyde (MDA), tumor necrosis-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and decreased the activities of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) in left ventricles. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 95-112 28720397-3 2017 ISO-induced myocardial damage was indicated by elevated levels of cardiac specific troponin-T, enhanced myocardial expression of proinflammatory cytokines (interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha), and increased number of cells with apoptotic and necrotic appearance in the myocardial tissue. Isoproterenol 0-3 interleukin 1 beta Rattus norvegicus 156-173 22944319-4 2013 Prior isoproterenol treatment significantly enhanced IL-1beta and IL-6, but not TNF-alpha production following LPS stimulation. Isoproterenol 6-19 interleukin 1 beta Rattus norvegicus 53-61 22694660-8 2012 Isoproterenol enhanced the content of malondialdehyde (MDA), tumor necrosis-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and decreased the activities of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) in left ventricles. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 114-122 18487443-6 2008 Isoproterenol enhanced aortic mRNA and protein expression of IL-1beta (124% and 125%) and IL-6 (231% and 40%) compared with controls but did not change TNF-alpha expression. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 61-69 21763302-6 2011 In addition, isoproterenol induced group electrocardiogram showed an elevation in ST segments and increased expressions of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha genes in the myocardium. Isoproterenol 13-26 interleukin 1 beta Rattus norvegicus 123-140 21762681-10 2011 The higher expressions of pro-inflammatory cytokines such as interleukin-1beta, interleukin-6 and tumour necrosis factor-alpha in the isoproterenol-induced rats were controlled by the pretreatment with ellagic acid. Isoproterenol 134-147 interleukin 1 beta Rattus norvegicus 61-78 20452680-5 2010 Isoproterenol (beta-AR agonist) treatment induced a time- and concentration-dependent increase of IL-1beta in cells. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 98-106 20452680-6 2010 Both ERK1/2 and P38 MAPK inhibitor, but not PKA and JNK1/2 inhibitor abrogated isoproterenol-induced IL-1beta and IL-6 production in microglia cells. Isoproterenol 79-92 interleukin 1 beta Rattus norvegicus 101-109 16165282-9 2005 injection of 5.0 mg/kg isoproterenol (beta-adrenoceptor agonist) was sufficient to induce circulating IL-1 and IL-6, and tissue IL-1beta. Isoproterenol 23-36 interleukin 1 beta Rattus norvegicus 128-136 17962483-5 2007 RESULTS: Isoproterenol treatment significantly decreased protein levels of iNOS, TNF-alpha, and IL-1B, in rMC-1 cells cultured in high glucose as early as 1 hour, compared with cells receiving no treatment. Isoproterenol 9-22 interleukin 1 beta Rattus norvegicus 96-101 17962483-9 2007 Isoproterenol significantly increased gene expression for IL-1B after 24 hours of treatment. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 58-63 17962483-10 2007 CONCLUSIONS: These results suggest that stimulation of beta-adrenergic receptors with isoproterenol leads to decreased levels of PGE(2), TNF-alpha, and IL-1B protein content, and in both gene expression and protein levels of iNOS in Muller cells cultured in hyperglycemia. Isoproterenol 86-99 interleukin 1 beta Rattus norvegicus 152-157 15316244-7 2004 IL-1 beta and LPC synergistically enhanced release of IL-6 in the presence of the beta-adrenergic receptor agonist isoproterenol (ISO); these effects were largely reversed by SRIF or GABA. Isoproterenol 115-128 interleukin 1 beta Rattus norvegicus 0-9 15316244-7 2004 IL-1 beta and LPC synergistically enhanced release of IL-6 in the presence of the beta-adrenergic receptor agonist isoproterenol (ISO); these effects were largely reversed by SRIF or GABA. Isoproterenol 130-133 interleukin 1 beta Rattus norvegicus 0-9 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Isoproterenol 246-259 interleukin 1 beta Rattus norvegicus 57-74 12457245-10 2002 IL-1beta-treated cells had reduced responses to isoproterenol as evidenced by a lack of enhanced amplitude of contraction and a reduction in cAMP production. Isoproterenol 48-61 interleukin 1 beta Rattus norvegicus 0-8 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Isoproterenol 246-259 interleukin 1 beta Rattus norvegicus 76-84 11093787-3 2000 Simultaneous incubation of cells with isoproterenol enhances the response to IL-1beta, even though isoproterenol alone is without effect. Isoproterenol 38-51 interleukin 1 beta Rattus norvegicus 77-85 11861327-7 2002 The density of beta(2)-adrenoceptors was significantly reduced in lung membranes harvested from IL-1beta-treated rats, which was associated with impaired isoproterenol- and forskolin-stimulated cyclic AMP accumulation and adenylyl cyclase (AC) activity ex vivo. Isoproterenol 154-167 interleukin 1 beta Rattus norvegicus 96-104 11861327-8 2002 Dexamethasone did not prevent IL-1beta-induced down-regulation of beta(2)-adrenoceptors but completely blocked IL-1beta-induced impairment of cyclic AMP accumulation and AC activity stimulated by isoproterenol and forskolin. Isoproterenol 196-209 interleukin 1 beta Rattus norvegicus 111-119 11093787-3 2000 Simultaneous incubation of cells with isoproterenol enhances the response to IL-1beta, even though isoproterenol alone is without effect. Isoproterenol 99-112 interleukin 1 beta Rattus norvegicus 77-85 11093787-7 2000 Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol. Isoproterenol 67-80 interleukin 1 beta Rattus norvegicus 84-92 11093787-7 2000 Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol. Isoproterenol 213-226 interleukin 1 beta Rattus norvegicus 84-92 10722808-8 2000 Addition of isoproterenol significantly increased nitrite production by IL-1 beta-stimulated cardiac myocytes. Isoproterenol 12-25 interleukin 1 beta Rattus norvegicus 72-81 1686311-8 1991 injection of the beta-adrenoceptor agonist isoproterenol (1 and 3 micrograms/rat) dose-dependently increased the hypothalamic level of IL-1 beta mRNA. Isoproterenol 43-56 interleukin 1 beta Rattus norvegicus 135-144 9369341-0 1997 Intracerebroventricular injection of isoproterenol produces its analgesic effect through interleukin-1beta production. Isoproterenol 37-50 interleukin 1 beta Rattus norvegicus 89-106 9369341-1 1997 The effects of isoproterenol, a beta-adrenoceptor agonist, on the production of interleukin-1beta in the brain and on mechanical nociception were examined in rats. Isoproterenol 15-28 interleukin 1 beta Rattus norvegicus 80-97 9369341-3 1997 injection of isoproterenol at the dose of 3 microg/rat markedly induced interleukin-1beta mRNA in the molecular layer of the hippocampus, medial preoptic area, paraventricular thalamic nucleus, paraventricular hypothalamic nucleus, ventromedial hypothalamic nucleus, dorsomedial hypothalamic nucleus and central gray 1 h after injection. Isoproterenol 13-26 interleukin 1 beta Rattus norvegicus 72-89 9369341-10 1997 These results suggest that isoproterenol produces an analgesic effect, at least in part, through the induction of interleukin-1beta expression in the brain. Isoproterenol 27-40 interleukin 1 beta Rattus norvegicus 114-131 8878428-3 1996 Contractile responses to electrical field stimulation and to carbachol were not altered, but maximal relaxation induced by isoproterenol (10(-6)-10(-5) M) was significantly reduced 24 h after IL-1beta treatment in tracheal tissues and to a lesser extent, in the main bronchi. Isoproterenol 123-136 interleukin 1 beta Rattus norvegicus 192-200 8878428-6 1996 Isoproterenol-stimulated cyclic AMP accumulation was reduced by IL-1beta at 24 h in trachea and lung tissues. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 64-72 7478305-2 1995 The present in vitro studies using northern blot analysis showed that the beta-adrenoceptor agonist isoproterenol (1 x 10(-8) to 1 x 10(-5) M) caused a marked induction of IL-1 beta mRNA in microglia, but not in astrocytes. Isoproterenol 100-113 interleukin 1 beta Rattus norvegicus 172-181 7478305-7 1995 The induction of IL-1 beta mRNA by either isoproterenol or dbcAMP was strongly inhibited by a cAMP-dependent protein kinase inhibitor, H8. Isoproterenol 42-55 interleukin 1 beta Rattus norvegicus 17-26 7528998-8 1994 IL-1 beta induced the expression of inducible NOS mRNA in vascular SMC, which was enhanced by coincubation of IL-1 beta with either CGRP, isoproterenol, or forskolin. Isoproterenol 138-151 interleukin 1 beta Rattus norvegicus 0-9 7528998-8 1994 IL-1 beta induced the expression of inducible NOS mRNA in vascular SMC, which was enhanced by coincubation of IL-1 beta with either CGRP, isoproterenol, or forskolin. Isoproterenol 138-151 interleukin 1 beta Rattus norvegicus 110-119 1478730-4 1992 Proenkephalin mRNA expression was stimulated by IL-1 beta in a time- and concentration-dependent manner, being maximal with 5 U/ml IL-1 beta at 4 h. Although the beta-adrenergic agonist isoproterenol was also active, interferon, glutamate, and carbachol were not. Isoproterenol 186-199 interleukin 1 beta Rattus norvegicus 48-57 1478730-7 1992 These effects of IL-1 beta were region-specific, not being observed with either cerebellar or hippocampal astrocytes; however, isoproterenol was active in the latter cell populations. Isoproterenol 127-140 interleukin 1 beta Rattus norvegicus 17-26 9887027-2 1999 In the presence of isoproterenol (Iso), exposure for 3 min to IL-1beta suppressed the Iso-activated ICa,L. Isoproterenol 19-32 interleukin 1 beta Rattus norvegicus 62-70 9887027-2 1999 In the presence of isoproterenol (Iso), exposure for 3 min to IL-1beta suppressed the Iso-activated ICa,L. Isoproterenol 34-37 interleukin 1 beta Rattus norvegicus 62-70 9887027-3 1999 In the presence of IL-1beta, the response of ICa,L to Iso was decreased, and the EC50 for Iso stimulation was increased. Isoproterenol 54-57 interleukin 1 beta Rattus norvegicus 19-27 9139981-6 1997 After long-term treatment with IL-1beta or TNF, but not IL-1alpha, the significantly elevated levels of basal systolic calcium remain, and isoproterenol increases adenylate cyclase activity, unlike after short exposure. Isoproterenol 139-152 interleukin 1 beta Rattus norvegicus 31-39 8732506-7 1996 The synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol. Isoproterenol 128-141 interleukin 1 beta Rattus norvegicus 34-43 34507121-0 2021 L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction. Isoproterenol 167-180 interleukin 1 beta Rattus norvegicus 141-158 34306253-6 2021 Strikingly, in HF rats induced by isoproterenol (ISO), the expression of miR-181b of heart tissue was suppressed before tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) increase, as revealed by western blot and real-time PCR. Isoproterenol 34-47 interleukin 1 beta Rattus norvegicus 161-178 34306253-6 2021 Strikingly, in HF rats induced by isoproterenol (ISO), the expression of miR-181b of heart tissue was suppressed before tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) increase, as revealed by western blot and real-time PCR. Isoproterenol 49-52 interleukin 1 beta Rattus norvegicus 161-178