PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31447681-7 2019 Similarly, aldosterone prevented the activation of extracellular signal-regulated kinase (ERK) and the production of cyclic adenosine 3",5"-monophosphate (cAMP) in response to the beta1/beta2AR agonist, isoproterenol. Isoproterenol 203-216 hemoglobin, beta adult major chain Mus musculus 180-185 31230416-3 2019 For this purpose, alpha1 -ARs were activated with phenylephrine (PH) and beta1/2 -ARs with isoprenaline (ISOP). Isoproterenol 91-103 hemoglobin, beta adult major chain Mus musculus 73-80 31230416-3 2019 For this purpose, alpha1 -ARs were activated with phenylephrine (PH) and beta1/2 -ARs with isoprenaline (ISOP). Isoproterenol 105-109 hemoglobin, beta adult major chain Mus musculus 73-80 12094073-9 2002 Isoproterenol increased the cAMP level 38-fold and beating rate, cell motion, %shortening, and contractile velocity by 48%, 38%, 27%, and 51%, respectively, and the increases were blocked by CGP20712A (beta1-selective blocker). Isoproterenol 0-13 hemoglobin, beta adult major chain Mus musculus 202-207 26936457-7 2016 The investigated model reproduces most of the experimentally observed effects of moderate stimulation of beta1-ARs, PKA, and PDE4 inhibition on the L-type Ca(2+) current, [Ca(2+)]i transients, and the sarcoplasmic reticulum Ca(2+) load and makes testable predictions for the action potential duration and [Ca(2+)]i transients as functions of isoproterenol concentration. Isoproterenol 342-355 hemoglobin, beta adult major chain Mus musculus 105-110 20369594-3 2010 On the contrary, the nonselective beta-1/beta2/beta-3 adrenoceptor agonist isoprenaline (10(-8) - 10(-7) M) was a coronary vasodilator and caused dose-dependent increase in the coronary flow. Isoproterenol 75-87 hemoglobin, beta adult major chain Mus musculus 34-40 26692570-6 2016 Intriguingly, acute treatment of mice with beta1- and beta2-AR agonist isoproterenol resulted in myocardial ErbB2 increase, while inhibition with either beta1- or beta2-AR antagonist did not completely prevent isoproterenol-induced ErbB2 expression. Isoproterenol 71-84 hemoglobin, beta adult major chain Mus musculus 43-48 26692570-6 2016 Intriguingly, acute treatment of mice with beta1- and beta2-AR agonist isoproterenol resulted in myocardial ErbB2 increase, while inhibition with either beta1- or beta2-AR antagonist did not completely prevent isoproterenol-induced ErbB2 expression. Isoproterenol 210-223 hemoglobin, beta adult major chain Mus musculus 43-48 26181106-6 2015 2) Among the neurotransmitter receptors, adrenergic receptors alpha1a, alpha2a, alpha2b, and beta1 were all highly expressed, with norepinephrine and isoproterenol acting as positive regulators. Isoproterenol 150-163 hemoglobin, beta adult major chain Mus musculus 93-98 18006484-5 2008 The effect of isoproterenol was antagonized by CGP20712A and ICI118551 (beta1- or beta2-AR antagonists, respectively) and also partially inhibited by N omega-nitro-L-arginine methylester (L-NAME, a NOS inhibitor), endothelium denudation, or eNOS gene deletion. Isoproterenol 14-27 hemoglobin, beta adult major chain Mus musculus 72-77 15016730-5 2004 Comparison of isoproterenol-sensitive AFC in mice with beta1- but not beta2-adrenergic receptors to beta1AR-/-/beta2AR-/- mice indicates that the beta2AR mediates the bulk of beta-adrenergic-sensitive alveolar active Na+ transport. Isoproterenol 14-27 hemoglobin, beta adult major chain Mus musculus 55-60 9227631-11 1997 Isoproterenol significantly increased 22Na+ uptake to 345 +/- 23 compared with a basal rate of 256 +/- 12 nmol.min-1.mg protein-1 and was blocked with propranolol and beta 1- and beta 2-selective antagonists. Isoproterenol 0-13 hemoglobin, beta adult major chain Mus musculus 167-185 11485548-8 2001 When beta1-adrenergic stimulation was blocked by simultaneous treatment with isoproterenol and the beta1 antagonist atenolol, a significant, although reduced, hypertrophy was still present in the hearts of transgenic mice, suggesting that both beta1 and beta2 adrenergic receptors contribute to the hypertrophic phenotype. Isoproterenol 77-90 hemoglobin, beta adult major chain Mus musculus 5-10 11193510-3 2000 The chronotropic response to isoproterenol was significantly attenuated in beta 1 AR KO and beta 1/beta 2 KO, whereas there was no detrimental effect on heart rate in beta 2 AR KO. Isoproterenol 29-42 hemoglobin, beta adult major chain Mus musculus 75-98 11193510-5 2000 In terms of the vasodilatory response to isoproterenol, there appears to be a graded and additive attenuation of the hypotensive response in beta 1 AR KO, beta 2 AR KO, and beta 1/beta 2 KO. Isoproterenol 41-54 hemoglobin, beta adult major chain Mus musculus 141-147 11193510-5 2000 In terms of the vasodilatory response to isoproterenol, there appears to be a graded and additive attenuation of the hypotensive response in beta 1 AR KO, beta 2 AR KO, and beta 1/beta 2 KO. Isoproterenol 41-54 hemoglobin, beta adult major chain Mus musculus 173-179 10929058-4 2000 The suppressive effect of adrenaline on NO production was mediated via beta1 and beta2 adrenergic receptors since isoprenaline (a non-selective beta1 and beta2 agonist), dobutamine and salbutamol (selective beta1 and beta2 agonists, respectively) had similar effects on the NO response. Isoproterenol 114-126 hemoglobin, beta adult major chain Mus musculus 71-76 10551282-4 1999 We used (-)-CGP 12177, an antagonist of beta1- and beta2-adrenoceptors with agonist properties at the putative beta4-adrenoceptor, and (-)-isoprenaline as an agonist for beta1- and beta2-adrenoceptors. Isoproterenol 135-151 hemoglobin, beta adult major chain Mus musculus 170-175 11641423-6 2001 In aortic and carotid arteries and in portal veins, the vasodilating effect of isoproterenol was reduced in mice lacking beta(1)- or beta(2)-receptors. Isoproterenol 79-92 hemoglobin, beta adult major chain Mus musculus 121-129 11641423-9 2001 Similar contributions of beta(1)- and beta(2)-receptors to isoproterenol-induced vasorelaxation were found when vessels from KO mice were compared with wild-type arteries in the presence of subtype-selective beta-receptor antagonists. Isoproterenol 59-72 hemoglobin, beta adult major chain Mus musculus 25-33 2158543-6 1990 This was demonstrated using the beta-1 adrenergic selective antagonist ICI 89.406 and the beta-2 adrenergic selective antagonist ICI 118.551 to inhibit competitively isoproterenol-stimulated cAMP accumulation. Isoproterenol 166-179 hemoglobin, beta adult major chain Mus musculus 32-38 3017363-7 1986 The superior affinity of the above isoproterenol congeners for both beta 1 and beta 2 adrenergic receptors makes these compounds excellent candidates for use as labeled agonist ligands in studies of beta receptors. Isoproterenol 35-48 hemoglobin, beta adult major chain Mus musculus 68-85 8851174-8 1996 The respective contributions of the beta 1- and the beta 3-subtypes to the production of cAMP were resolved by an Eadie-Hofstee computer analysis of isoproterenol and norepinephrine concentration-response curve of adenylyl cyclase activity. Isoproterenol 149-162 hemoglobin, beta adult major chain Mus musculus 36-42 7913199-8 1994 Parallel tests with beta-adrenergic antagonists revealed that the potentiation by isoproterenol could be significantly diminished by a single dose of the non-selective beta-adrenoreceptor blocking drug nadolol or the beta 2-selective antagonist ICI-118,551, but not the beta 1-selective antagonist metoprolol. Isoproterenol 82-95 hemoglobin, beta adult major chain Mus musculus 270-276 1975811-4 1990 Long term exposure of either differentiating cells or mature adipocytes to dexamethasone induced down-regulation of (-)-isoproterenol-sensitive adenylate cyclase activity which paralleled a 2- to 3.5-fold decrease in beta-ARs, while the beta 1/beta 2 ratio switched to approximately 20/80. Isoproterenol 116-133 hemoglobin, beta adult major chain Mus musculus 237-250