PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16270351-8 2006 Isoproterenol treatment of first passage scar myofibroblasts increased protein synthesis and induced BNP mRNA expression, whereas ANP mRNA levels remained unchanged. Isoproterenol 0-13 natriuretic peptide B Rattus norvegicus 101-104 29164560-1 2017 OBJECTIVE: The objective of this study was to observe the expression of transforming growth factor-beta1 (TGF-beta1) in myocardial tissue and the concentration of serum B-type natriuretic peptide (BNP) in myocardial remodeling of Sprague-Dawley rats induced by isoproterenol (ISO) and the effects of carvedilol intervention. Isoproterenol 261-274 natriuretic peptide B Rattus norvegicus 169-195 29164560-1 2017 OBJECTIVE: The objective of this study was to observe the expression of transforming growth factor-beta1 (TGF-beta1) in myocardial tissue and the concentration of serum B-type natriuretic peptide (BNP) in myocardial remodeling of Sprague-Dawley rats induced by isoproterenol (ISO) and the effects of carvedilol intervention. Isoproterenol 261-274 natriuretic peptide B Rattus norvegicus 197-200 29164560-1 2017 OBJECTIVE: The objective of this study was to observe the expression of transforming growth factor-beta1 (TGF-beta1) in myocardial tissue and the concentration of serum B-type natriuretic peptide (BNP) in myocardial remodeling of Sprague-Dawley rats induced by isoproterenol (ISO) and the effects of carvedilol intervention. Isoproterenol 276-279 natriuretic peptide B Rattus norvegicus 169-195 29164560-1 2017 OBJECTIVE: The objective of this study was to observe the expression of transforming growth factor-beta1 (TGF-beta1) in myocardial tissue and the concentration of serum B-type natriuretic peptide (BNP) in myocardial remodeling of Sprague-Dawley rats induced by isoproterenol (ISO) and the effects of carvedilol intervention. Isoproterenol 276-279 natriuretic peptide B Rattus norvegicus 197-200 27802898-6 2016 Administration of OMT significantly reduced the increased BNP in plasm of isoproterenol-induced rats, attenuated cardiac fibrosis,suppressed overexpression of myocardial COX-1 expression, up-regulated COX-2 and PGIS expression, but had no effects on isoproterenol-induced elevated protein cPLA2. Isoproterenol 74-87 natriuretic peptide B Rattus norvegicus 58-61 25332004-7 2014 But after isoprenaline injection in ovariectomized rats, LVSP and +dp/dt(max) declined (P < 0.01), LVEDP and -dp/dt(max) elevated (P < 0.01); plasma BNP concentration increased (P < 0.01); plasma cAMP concentration decreased (P < 0.01), compared with OVX group. Isoproterenol 10-22 natriuretic peptide B Rattus norvegicus 155-158 25136580-8 2014 ANP and BNP increased and that of MMP-2 increased in isoproterenol twice treated group compared to control group, without CTGF. Isoproterenol 53-66 natriuretic peptide B Rattus norvegicus 8-11 23466634-5 2013 Our results demonstrated that isoproterenol significantly increased the expression of hypertrophic marker, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), parallel to a significant increase in cell surface area. Isoproterenol 30-43 natriuretic peptide B Rattus norvegicus 144-169 23466634-5 2013 Our results demonstrated that isoproterenol significantly increased the expression of hypertrophic marker, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), parallel to a significant increase in cell surface area. Isoproterenol 30-43 natriuretic peptide B Rattus norvegicus 171-174 23176298-12 2013 In H9c2 cells, isoprenaline caused a significant induction of ANP, BNP and EPHX2 mRNA levels. Isoproterenol 15-27 natriuretic peptide B Rattus norvegicus 67-70 23176298-13 2013 Both TUPS and 11,12-EET significantly decreased this isoprenaline-mediated induction of ANP, BNP and EPHX2. Isoproterenol 53-65 natriuretic peptide B Rattus norvegicus 93-96 32461996-5 2020 In neonatal rat cardiomyocytes (NRCMs), siRNA-mediated JMJD1A knockdown facilitated ISO or angiotensin II-induced increase in cardiomyocyte size, protein synthesis, and expression of hypertrophic fetal genes, including atrial natriuretic peptide (Anp), brain natriuretic peptide (Bnp), and Myh7. Isoproterenol 84-87 natriuretic peptide B Rattus norvegicus 253-278 32461996-5 2020 In neonatal rat cardiomyocytes (NRCMs), siRNA-mediated JMJD1A knockdown facilitated ISO or angiotensin II-induced increase in cardiomyocyte size, protein synthesis, and expression of hypertrophic fetal genes, including atrial natriuretic peptide (Anp), brain natriuretic peptide (Bnp), and Myh7. Isoproterenol 84-87 natriuretic peptide B Rattus norvegicus 280-283 31545484-8 2019 STVNa significantly reduced cell surface area and decreased BNP mRNA expression in ventricular cardiomyocyte Iso-induced hypertrophy. Isoproterenol 109-112 natriuretic peptide B Rattus norvegicus 60-63 29986596-3 2018 Phalloidin staining showed that treatment with the extract dramatically prevents isoproterenol-induced H9c2 cell enlargement and the expression of cardiac hypertrophic marker genes, including atrial natriuretic peptide (ANP) and B-type brain natriuretic peptide (BNP). Isoproterenol 81-94 natriuretic peptide B Rattus norvegicus 236-261 29986596-3 2018 Phalloidin staining showed that treatment with the extract dramatically prevents isoproterenol-induced H9c2 cell enlargement and the expression of cardiac hypertrophic marker genes, including atrial natriuretic peptide (ANP) and B-type brain natriuretic peptide (BNP). Isoproterenol 81-94 natriuretic peptide B Rattus norvegicus 263-266 25310909-4 2014 After continuous preventive administration of oxymatrine for 7 days, significant isoproterenol-induced heart failure characterized by hypertrophy and dysfunction of left ventricle, and elevation of brain natruretic peptide (BNP, a heart failure biomarker) and cardiac troponin I (cTn-I, a cardiac injury biomarker) was observed. Isoproterenol 81-94 natriuretic peptide B Rattus norvegicus 224-227 25310909-5 2014 Preventive oxymatrine significantly ameliorated the cardiac hypertrophy, improved the left ventricular dysfunction and reduced the increased BNP and cTn-I in serum of isoproterenol-treated rats. Isoproterenol 167-180 natriuretic peptide B Rattus norvegicus 141-144 24289757-0 2013 B-type natriuretic peptide and adiponectin releases in rat model of myocardial damage induced by isoproterenol administration. Isoproterenol 97-110 natriuretic peptide B Rattus norvegicus 0-26 23466634-7 2013 On other hand, 14,15-EET significantly attenuated the isoproterenol-mediated induction of ANP, BNP, CYP1A1, CYP2J3, CYP4F4, CYP4F5 and EPHX2. Isoproterenol 54-67 natriuretic peptide B Rattus norvegicus 95-98 25610063-0 2009 Effects of Lacidipine, Ramipril and Valsartan on Serum BNP Levels in Acute and Chronic Periods Following Isoproterenol-Induced Myocardial Infarction in Rats. Isoproterenol 105-118 natriuretic peptide B Rattus norvegicus 55-58 15659305-2 2005 In rats with isoproterenol alone, the myocardium necrosis occurred and the cardiac function was inhibited; the BNP contents in plasma and myocardium were upregulated, so did the myocardial corin mRNA level; the NEP activity in plasma and myocardium were downregulated. Isoproterenol 13-26 natriuretic peptide B Rattus norvegicus 111-114 9043801-2 1997 We investigated the regulation of the atrial natriuretic peptide and brain natriuretic peptide genes in a rat model of myocardial infarction induced by isoproterenol (IP rat) and in a rat model of cardiac hypertrophy induced by aorto-caval shunt (AC shunt rat). Isoproterenol 152-165 natriuretic peptide B Rattus norvegicus 69-94 9043801-4 1997 Brain natriuretic peptide (BNP) mRNA levels in atria were significantly higher in IP rats than in controls at 18 h after the administration of isoproterenol, but not significant increases were observed in atrial natriuretic peptide (ANP) mRNA expression levels at any time point examined. Isoproterenol 143-156 natriuretic peptide B Rattus norvegicus 0-25 9043801-4 1997 Brain natriuretic peptide (BNP) mRNA levels in atria were significantly higher in IP rats than in controls at 18 h after the administration of isoproterenol, but not significant increases were observed in atrial natriuretic peptide (ANP) mRNA expression levels at any time point examined. Isoproterenol 143-156 natriuretic peptide B Rattus norvegicus 27-30 9043801-5 1997 In the ventricles, the BNP mRNA levels peaked at 18 h after isoproterenol administration, whereas ANP mRNA levels gradually increased until 3 days after isoproterenol administration. Isoproterenol 60-73 natriuretic peptide B Rattus norvegicus 23-26 34684485-11 2021 Cardiac hypertrophy biomarkers such as beta-MHC, ANP, BNP, LDH, and CK-MB, which were increased by ISO, were significantly decreased by BA treatment. Isoproterenol 99-102 natriuretic peptide B Rattus norvegicus 54-57 34956570-8 2021 Isoproterenol significantly enlarged the volume of cardiomyocytes (p < 0.001), upregulated mRNA and expression levels of ANP and BNP proteins (p < 0.001), increased extracellular Ca2+ concentration and CaN activity (p < 0.001), and upregulated NFATc3 phosphorylation in the nucleus (p < 0.001). Isoproterenol 0-13 natriuretic peptide B Rattus norvegicus 129-132 34494132-4 2021 ISO treatment increased the levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and beta-myosin heavy chain (beta-MHC) in NRCMs, and reduced the levels of collagen I, collagen III, fibronectin, and alpha-smooth muscle actin (alpha-SMA) in NRCFs. Isoproterenol 0-3 natriuretic peptide B Rattus norvegicus 72-97 34494132-4 2021 ISO treatment increased the levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and beta-myosin heavy chain (beta-MHC) in NRCMs, and reduced the levels of collagen I, collagen III, fibronectin, and alpha-smooth muscle actin (alpha-SMA) in NRCFs. Isoproterenol 0-3 natriuretic peptide B Rattus norvegicus 99-102