PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28819818-5	2018	Isoproterenol-induced myocardial infarcted rats showed a significant increase in the levels of cardiac diagnostic markers, heart mitochondrial lipid peroxidation, calcium ion, and a significant decrease in the levels of heart mitochondrial glutathione peroxidase, reduced glutathione, glutathione-S-transferase, isocitrate, malate, alpha-ketoglutarate, and succinate dehydrogenases.	Isoproterenol	0-13	hematopoietic prostaglandin D synthase	Rattus norvegicus	285-310	
25893851-4	2015	RESULTS: ISO treated rats showed significant increase in the levels of thiobarbituric acid reactive substances (TBARS) and decreased levels of reduced glutathione, glutathione perdoxidase, glutathione reductase and glutathione-S- transferase in the cardiac tissues.	Isoproterenol	9-12	hematopoietic prostaglandin D synthase	Rattus norvegicus	215-241	
28508188-4	2018	ISO administration significantly increased the heart weight and cardiac marker enzymes in serum, xanthine oxidase, sodium, and calcium in the heart, whereas significantly decreased body weight, reduced glutathione, glutathione-S-transferase, superoxide dismutase, and potassium in the heart.	Isoproterenol	0-3	hematopoietic prostaglandin D synthase	Rattus norvegicus	215-240	
20045540-5	2010	The ISO-induced rats showed significant increase in the levels of thiobarbituric acid reactive substances, lipid hydroperoxides in the heart, plasma uric acid, and serum cardiac marker enzymes, and significant decrease in the activities of heart superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and the levels of reduced glutathione, vitamin E, and vitamin C in the plasma and heart.	Isoproterenol	4-7	hematopoietic prostaglandin D synthase	Rattus norvegicus	325-350	
17084010-2	2006	Subcutaneous injection of ISO (85 mg/kg) to male Wistar rats showed a significant increase in the levels of thiobarbituric acid reactive substances and lipid hydroperoxides in plasma and the heart and a significant decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in the heart and the levels of reduced glutathione, vitamin C and vitamin E in plasma and heart and ceruloplasmin in plasma.	Isoproterenol	26-29	hematopoietic prostaglandin D synthase	Rattus norvegicus	304-329	
18844325-2	2009	Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities/levels of mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione).	Isoproterenol	34-37	hematopoietic prostaglandin D synthase	Rattus norvegicus	305-330	
18078734-3	2008	ISO-treated rats show a significant increase in the levels of thiobarbituric acid reactive substances, lipid hydroperoxides in plasma and heart and plasma uric acid and a significant decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase in heart and the levels of reduced glutathione, vitamin C and vitamin E in plasma and the heart and ceruloplasmin in plasma.	Isoproterenol	0-3	hematopoietic prostaglandin D synthase	Rattus norvegicus	295-320	
18456509-5	2008	ISO-induced rats showed significant increase in mitochondrial lipid peroxidation products (thiobarbituric acid reactive substances and lipid hydroperoxides) and significant decrease in mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and reduced glutathione).	Isoproterenol	0-3	hematopoietic prostaglandin D synthase	Rattus norvegicus	269-294	
15282960-2	2004	The activity of heart tissue antioxidants like glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase were significantly decreased in isoproterenol administered group.	Isoproterenol	177-190	hematopoietic prostaglandin D synthase	Rattus norvegicus	119-144	
16757080-4	2006	ISO-induced rats also showed a significant decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase in heart and the levels of glutathione and ascorbic acid in plasma and heart.	Isoproterenol	0-3	hematopoietic prostaglandin D synthase	Rattus norvegicus	155-180	
9774493-5	1998	Isoproterenol (ISO) was administered to rats in two doses so as to evaluate their beta-adrenergic and toxicological actions in terms of lipid peroxidation (LPO) and the changes in the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) and glutathione (GSH) content in heart, liver and kidney.	Isoproterenol	0-13	hematopoietic prostaglandin D synthase	Rattus norvegicus	256-281	
12557918-4	2000	Activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase, glutathione reductase were decreased significantly in heart with isoproterenol-induced myocardial necrosis.	Isoproterenol	187-200	hematopoietic prostaglandin D synthase	Rattus norvegicus	95-120	
10846629-8	2000	The erythrocyte GSH content and glutathione-S-transferase (GST) activity decreased with isoproterenol treatment as compared to control.	Isoproterenol	88-101	hematopoietic prostaglandin D synthase	Rattus norvegicus	32-57	
10846629-8	2000	The erythrocyte GSH content and glutathione-S-transferase (GST) activity decreased with isoproterenol treatment as compared to control.	Isoproterenol	88-101	hematopoietic prostaglandin D synthase	Rattus norvegicus	59-62	
12067254-10	2002	The content of total glutathione (intra- and extracellular) and the intracellular activity of the selenium-dependent glutathione peroxidase, glutathione reductase, and glutathione-S-transferase were also decreased in the isoproterenol plus Cu2+ samples.	Isoproterenol	221-234	hematopoietic prostaglandin D synthase	Rattus norvegicus	168-193	
9774493-5	1998	Isoproterenol (ISO) was administered to rats in two doses so as to evaluate their beta-adrenergic and toxicological actions in terms of lipid peroxidation (LPO) and the changes in the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) and glutathione (GSH) content in heart, liver and kidney.	Isoproterenol	0-13	hematopoietic prostaglandin D synthase	Rattus norvegicus	283-286	
31762605-8	2019	GST, GPX, GSH, Na+/K+, Mg2+, Ca2+ ATPases, K+ ions were significantly decreased while Na+ and Ca2+ ions were increased in the heart tissues of ISO-injected rats.	Isoproterenol	143-146	hematopoietic prostaglandin D synthase	Rattus norvegicus	0-3	
31313346-8	2019	Activities of enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) in erythrocytes and heart tissue and the levels of nonenzymatic antioxidants like vitamin C, vitamin E, and reduced glutathione (GSH) in plasma and heart tissue were decreased in ISO-induced rats.	Isoproterenol	330-333	hematopoietic prostaglandin D synthase	Rattus norvegicus	146-149