PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22813780-6 2013 Administration of isoproterenol, which stimulates both beta1- and beta2-subtypes, also had trophic effects that differed in direction and critical period from those elicited by terbutaline; methoxamine, which stimulates alpha1-adrenoceptors, was without effect. Isoproterenol 18-31 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 55-71 25517116-3 2014 Mathematical simulations combined with biochemical experimentation of beta-AR signalling pathways show that the gradual increment of isoproterenol (a non-selective beta1/beta2-AR agonist) induces the switching response of Bcl-2 expression from the initial increase followed by a decrease below its basal level. Isoproterenol 133-146 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 164-169 23750689-7 2013 Repeated beta1 -blocker quickly counteracted the inhibitory effect of isoprenaline, and VPHs increased to (120.9 +- 2.4%) from (1.6 +- 1.0%; P < 0.05). Isoproterenol 70-82 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 9-14 21868696-7 2011 In the presence of aptamer neutralized beta1-AABs, cells remained fully responsive to agonists and antagonists, such as isoprenaline and bisoprolol. Isoproterenol 120-132 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 39-44 18687809-4 2008 Agonist responses to isoprenaline and CGP 12177 had different sensitivities to beta1-antagonists (e.g., CGP 20712A; log K(D) = -8.65 and -7.26, respectively). Isoproterenol 21-33 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 79-84 19250949-4 2009 The import is also stimulated by isoproterenol (a nonselective beta-adrenergic receptors agonist) and inhibited by metoprolol (a selective beta1 antagonist), strongly suggesting that nucleo-cytoplasmic shuttling of FBPase is under the control of beta1-adrenergic receptor-dependent Gs protein signaling cascade. Isoproterenol 33-46 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 139-144 19250949-4 2009 The import is also stimulated by isoproterenol (a nonselective beta-adrenergic receptors agonist) and inhibited by metoprolol (a selective beta1 antagonist), strongly suggesting that nucleo-cytoplasmic shuttling of FBPase is under the control of beta1-adrenergic receptor-dependent Gs protein signaling cascade. Isoproterenol 33-46 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 246-251 16571971-8 2006 Halothane, even at concentrations of 1.5 mm (approximately 5.6 MAC), had no effect on basal Galphas nucleotide exchange in the absence of isoproterenol, whereas halothane inhibited isoproterenol-promoted Galphas nucleotide exchange in both the beta1-Galphas and beta2-Galphas expressing membranes. Isoproterenol 181-194 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 244-249 15005238-9 2003 Isoproterenol increased the beating rate, which was blocked with CGP20712A (beta1-selective blocker). Isoproterenol 0-13 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 76-81 15710352-3 2005 Isoproterenol, a general beta(1)/beta(2) receptor agonist, and clenbuterol, a specific beta(2) receptor agonist, were both able to prevent the LPS-induced downregulation in CYP1A1/2 activity in astrocytes. Isoproterenol 0-13 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 25-32 15710352-4 2005 The involvement of beta-adrenergic receptors was confirmed using the general beta(1)/beta(2) receptor antagonist propranolol, which was able to abrogate the protection conferred by isoproterenol and clenbuterol in astrocytes treated with LPS. Isoproterenol 181-194 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 77-84 11810205-9 2002 The chronotropic effect of changes in [NA+A] in HTR was similar to that of combined beta1- and beta2-adrenergic activation evoked by applying isoprenaline to isolated heart myocytes (Brodde OE, Pharmacol Ther 60:405-430, 1993). Isoproterenol 142-154 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 84-100 12520158-2 2003 Because the alpha(1)-, beta(1,2)-blocker, carvedilol, has been shown to be outstandingly beneficial in the treatment of heart failure, its direct effects on intracellular calcium ion concentration ([Ca(2+)](i)), including antagonism to isoproterenol, in ventricular myocytes were investigated and then compared with a selective beta(1)-blocker, atenolol, and a non-selective beta(1,2)-blocker, timolol. Isoproterenol 236-249 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 23-31 12494500-9 2002 Isoproterenol increased the beating rate, which was blocked with CGP20712A (beta 1-selective blocker). Isoproterenol 0-13 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 76-82 9128405-10 1996 We performed bolus infusion tests of noradrenaline and isoprenaline on patients with OH, and found that alpha-adrenoceptor-mediated rise in blood pressure was comparable to control, beta 1-mediated increase in heart rate was blunted, and beta 2-mediated fall in blood pressure was enhanced in OH. Isoproterenol 55-67 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 182-188 10484381-1 1999 Epinephrine and beta-adrenergic agonists (beta1 and beta2 for isoproterenol, beta1 for dobutamine, beta2 for salbutamol) stimulated K+ (or 86Rb) influx mediated by the Na+-K+-2Cl- cotransporter and the Na+-K+ pump in isolated colonic crypt cells. Isoproterenol 62-75 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 42-47 7804848-6 1994 The results provide evidence that the stimulation of both beta1 and beta2 adrenoceptors by isoproterenol acts in a synergistic manner to induce drinking and renin-angiotensin system activation. Isoproterenol 91-104 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 58-63 7654481-11 1995 Slope of log dose-response for heart rate and QS2i was similar with dobutamine and with isoprenaline, corresponding to stimulation of the same type of beta-adrenergic receptors (beta 1-subtype). Isoproterenol 88-100 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 178-184 7654481-13 1995 We conclude that the left ventricular contractile response assessed by QS2i provided the best parameter for evaluation of beta 1-adrenergic cardiac effects either with dobutamine or with isoprenaline. Isoproterenol 187-199 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 122-128 7804848-0 1994 The role of beta1 and beta2 adrenoceptors in isoproterenol-induced drinking. Isoproterenol 45-58 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 12-17 8622643-5 1996 At high concentrations (30 microM), salmeterol attenuated cAMP responses mediated by activation of beta 1-adrenoceptors by isoprenaline (Kp = 1.6 microM), indicating that salmeterol exhibited a low affinity for beta 1-adrenoceptors in C6 cells. Isoproterenol 123-135 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 99-105 7760507-1 1995 We attempted to determine the effects of transforming growth factor beta-1 on intracellular Ca2+ concentration changes in the presence of isoproterenol in cardiac fibroblasts. Isoproterenol 138-151 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 68-74 7760507-2 1995 Transforming growth factor beta-1 inhibited the increase of intracellular Ca2+ concentration in the presence of isoproterenol in fibroblasts. Isoproterenol 112-125 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 27-33 8121236-6 1994 Moreover, metoprolol and atenolol, two beta 1- AR- selective antagonists, shift the isoproterenol dose-response curve to the right with high potency as well. Isoproterenol 84-97 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 39-45 8072001-1 1994 The effects of transforming growth factor beta-1 on concentration of intracellular Ca2+ changes in the presence of isoproterenol were studied in cardiac fibroblasts. Isoproterenol 115-128 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 42-48 8072001-3 1994 Production of cyclic-AMP in fibroblasts preincubated with transforming growth factor beta-1 decreased compared with non-transforming growth factor beta-1-treated fibroblasts in the presence of isoproterenol. Isoproterenol 193-206 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 85-91 8072001-3 1994 Production of cyclic-AMP in fibroblasts preincubated with transforming growth factor beta-1 decreased compared with non-transforming growth factor beta-1-treated fibroblasts in the presence of isoproterenol. Isoproterenol 193-206 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 147-153 8072001-4 1994 An increase of intracellular Ca2+ concentration in the presence of isoproterenol was also inhibited in transforming growth factor beta-1-treated fibroblasts. Isoproterenol 67-80 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 130-136 1968697-2 1990 In vitro on both isolated electrically driven right and left atrial and left papillary muscle preparations, isoprenaline and adrenaline caused positive inotropic effects via beta-1 and beta-2 adrenoceptor stimulation. Isoproterenol 108-120 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 174-180 1352549-3 1992 Also, in chick heart cell membranes the relative ability of agonists to displace ICYP produced a profile typical of beta-1 adrenergic receptors with a rank order of potency or efficacy of: isoproterenol greater than epinephrine = norephinephrine. Isoproterenol 189-202 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 116-122 1363262-3 1992 Both beta 1- and beta 2-adrenoceptors couple to adenylate cyclase and mediate positive inotropic effects of isoprenaline and adrenaline on isolated, electrically driven cardiac preparations. Isoproterenol 108-120 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 5-11 1981809-9 1990 Metoprolol (10(-6) M), a selective beta 1-receptor antagonist, shifted the concentration-response curve for isoprenaline to the right, but left the maximal response unchanged. Isoproterenol 108-120 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 35-41 1971539-2 1990 The blockade was evaluated by analyzing the variations of the beta 1- and beta 2-blockade effects of isoproterenol before and after instillation of one drop in each eye. Isoproterenol 101-114 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 62-80 1971539-4 1990 Comparison of the blockade by these drops showed that carteolol and timolol totally inhibited the beta 1 and beta 2 effects of a dose of isoproterenol able to increase heart rate by 50% (placebo eyedrops were used as a control). Isoproterenol 137-150 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 98-115 1968697-5 1990 In vivo in 10 healthy volunteers isoprenaline-induced tachycardia was antagonized with equal potency by the beta-2 adrenoceptor-selective antagonist ICI 118,551 and the beta-1 adrenoceptor-selective antagonist bisoprolol indicating that it is mediated by cardiac beta-1 and beta-2 adrenoceptor stimulation to about the same degree. Isoproterenol 33-45 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 169-175 1671088-2 1991 When the cells were exposed to beta-adrenergic agonists, they accumulated cyclic AMP in the following order of potency: isoproterenol much greater than norepinephrine greater than epinephrine, which is indicative of a beta 1-subtype receptor. Isoproterenol 120-133 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 218-224 11527117-3 1990 Both beta1- and beta2-adrenoceptors couple to adenylate cyclase and mediate positive inotropic effects of isoproterenol and epinephrine on isolated, electrically driven cardiac preparations. Isoproterenol 106-119 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 5-21 2900601-3 1988 In isolated, electrically driven strips of human right atria, isoproterenol increased contractile force through stimulation of both beta 1 and beta 2 adrenoceptors, while the selective beta 2-adrenoceptor agonist, procaterol, caused its positive inotropic effect predominantly through beta 2-adrenoceptor stimulation. Isoproterenol 62-75 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 132-149 2839668-6 1988 An isoprenaline dose ratio (DR)-1 of 1 coincided with a 50% occupancy of the beta-1 or the beta-2 subtype in vitro. Isoproterenol 3-15 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 77-83 2839668-10 1988 An isoprenaline DR-1 of 1 coincided with a 50% occupancy of beta-1 adrenoceptors. Isoproterenol 3-15 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 60-66 6150925-4 1984 The beta 2-selective agonist terbutaline, eg, causes bronchodilation with less beta 1-cardiac excitation than does the beta 1-beta 2 nonselective agonist isoproterenol. Isoproterenol 154-167 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 119-125 2867205-8 1985 Addition of isoproterenol to the growth medium of intact cells resulted in an 80% decrease in the density of both beta-1 and beta-2 adrenergic receptors within 8 hr. Isoproterenol 12-25 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 114-120 3003961-5 1985 Isoprenaline- stimulated cAMP formation was blocked by the non- selective beta-adrenoceptor antagonists propranolol, timolol, and alprenolol, while the beta 1-selective antagonists atenolol and metoprolol had no influence on an isoprenaline-induced cAMP formation. Isoproterenol 0-12 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 152-158 6084778-4 1984 The beta 1-agonist dobutamine and the beta 2-agonists fenoterol and procaterol activated adenylate cyclase with an intrinsic activity of 0.5-0.7 (isoprenaline = 1.0). Isoproterenol 146-158 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 4-10 20550-5 1977 Isoproterenol stimulation was also inhibited by the selective beta1-adrenergic antagonist practolol. Isoproterenol 0-13 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 62-67 6131758-3 1983 The isoprenaline induced rise in PRA could be completely prevented by the beta 1-selective antagonists metoprolol (10 mg i.v. Isoproterenol 4-16 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 74-80 6138298-4 1983 The increase in SCC observed after terbutaline (beta 2-agonist) was similar to the increase after isoproterenol (beta 1- and beta 2-agonist). Isoproterenol 98-111 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 113-131 6130109-3 1983 Isoproterenol increases systolic blood pressure by increasing cardiac output through beta 1-adrenergic stimulation and lowers diastolic pressure by reducing peripheral resistance, which is a beta 2-adrenergic response. Isoproterenol 0-13 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 85-91 41815-7 1979 After beta-receptor blockade with either Bufuralol-hydrochloride or with Pindolol a shift to the right of the dose effect relationship concerning heart rate and cardiac output under Isoproterenol infusion was observed, indicating beta 1-blockade. Isoproterenol 182-195 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 230-236 6199591-8 1984 beta-Blockade with propranolol (nonselective), 80 mg four times a day, or atenolol (beta 1-selective), 100 mg once a day, antagonized the hypokalemic effect of isoproterenol as well as the rise in norepinephrine, but when isoproterenol was infused in doses high enough to overcome the blockade of the heart rate response, the effects on norepinephrine and potassium were abolished by propranolol and not by atenolol. Isoproterenol 160-173 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 84-90 6199591-8 1984 beta-Blockade with propranolol (nonselective), 80 mg four times a day, or atenolol (beta 1-selective), 100 mg once a day, antagonized the hypokalemic effect of isoproterenol as well as the rise in norepinephrine, but when isoproterenol was infused in doses high enough to overcome the blockade of the heart rate response, the effects on norepinephrine and potassium were abolished by propranolol and not by atenolol. Isoproterenol 222-235 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 84-90 6139182-4 1983 The relative potencies of isoprenaline, adrenaline, and noradrenaline for inhibition of (+/-)-[125I]iodocyanopindolol binding and activation of adenylate cyclase were 1:10:10, indicating a population composed mainly of beta 1-adrenoceptors. Isoproterenol 26-38 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 219-225 6854129-5 1983 Although the precise mechanisms are not fully elucidated, continuous chronotropic stimulation of the human heart with the beta 1 agonist, butopamine, elicits a significant reduction in the heart rate response to isoproterenol and exercise challenges. Isoproterenol 212-225 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 122-128 6263408-3 1981 Similar properties of beta 1- and beta 2-adrenergic-sensitive adenylate cyclases were found by computer analysis of the dose-response curves for isoprenaline in the presence of a constant concentration of practolol (a selective beta 1 antagonist) (55 plus or minus 10% and 45 plus or minus 10% of beta 1- and beta 2-sensitive adenylate cyclase respectively). Isoproterenol 145-157 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 22-40 6263408-3 1981 Similar properties of beta 1- and beta 2-adrenergic-sensitive adenylate cyclases were found by computer analysis of the dose-response curves for isoprenaline in the presence of a constant concentration of practolol (a selective beta 1 antagonist) (55 plus or minus 10% and 45 plus or minus 10% of beta 1- and beta 2-sensitive adenylate cyclase respectively). Isoproterenol 145-157 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 22-28