PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9202063-7	1997	Oral feeding of LY333531 prevented the increased mRNA expression of TGF-beta1 and extracellular matrix components such as fibronectin and alpha1(IV) collagen in the glomeruli of diabetic rats in parallel with inhibition of glomerular PKC activity.	ruboxistaurin	16-24	transforming growth factor, beta 1	Rattus norvegicus	68-77	
12955673-5	2003	In animal models of diabetes, including the streptozotocin (STZ) rat, Lepr(db)/Lepr(db) mouse, and STZ-Ren 2 rat models, ruboxistaurin normalized glomerular hyperfiltration, decreased urinary albumin excretion, and reduced glomerular transforming growth factor-beta1 and extracellular matrix protein production.	ruboxistaurin	121-134	transforming growth factor, beta 1	Rattus norvegicus	234-266	
26817709-0	2016	Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-beta1/Smad and GRAP pathways.	ruboxistaurin	0-13	transforming growth factor, beta 1	Rattus norvegicus	64-73	
26817709-1	2016	OBJECTIVE: To investigate whether ruboxistaurin (a selective PKC-beta inhibitor) mediates renoprotective effect via interference with TGF-beta1/Smad-GRAP cross-signalling.	ruboxistaurin	34-47	transforming growth factor, beta 1	Rattus norvegicus	134-143	
26817709-9	2016	A significant up-regulation of TGF-beta1, Smad2 and Smad3 mRNA expression was observed in diabetic rats, which was alleviated by administration of ruboxistaurin.	ruboxistaurin	147-160	transforming growth factor, beta 1	Rattus norvegicus	31-40	
26817709-10	2016	Furthermore, immunoblotting showed a significant improvement in protein levels of TGF-beta1 (P < 0.01), Smad2/3 (P < 0.01) and p-Smad3 (P < 0.001) in diabetic rats treated with ruboxistaurin compared to untreated.	ruboxistaurin	186-199	transforming growth factor, beta 1	Rattus norvegicus	82-91	
26817709-12	2016	CONCLUSION: These data suggest that the renoprotective effect of ruboxistaurin is possibly due to down-regulation of TGF-beta1/Smad pathway and normalization of GRAP protein expression.	ruboxistaurin	65-78	transforming growth factor, beta 1	Rattus norvegicus	117-126