PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6149693-5	1984	The effect of methoxamine (5 micrograms/min) on renin release was abolished by the intrarenal alpha 1-adrenoceptor blockade with prazosin (3 micrograms/min) but was not affected by the intrarenal alpha 2-adrenoceptor blockade with yohimbine (30 micrograms/min).	Prazosin	129-137	renin	Canis lupus familiaris	48-53	
2541403-2	1989	Renin stimulus-response curves were determined by a stepwise reduction of renal artery pressure down to 70 mm Hg (1) under control conditions, (2) during a bilateral common carotid occlusion combined with an intrarenal prazosin infusion, and (3) during an intrarenal methoxamine infusion.	Prazosin	219-227	renin	Canis lupus familiaris	0-5	
6264792-2	1981	The effect of alpha-adrenoceptor blockade by phenoxybenzamine (POB) or prazosin on renin secretion rate (RSR) was studied in pentobarbital-anesthetized dogs in which renal perfusion pressure was held constant with an adjustable aortic clamp.	Prazosin	71-79	renin	Canis lupus familiaris	83-88	
7049441-6	1982	After 7 days of hydralazine or prazosin administration, plasma renin activity remained elevated and blood volume increased from baseline values.	Prazosin	31-39	renin	Canis lupus familiaris	63-68	
7008886-6	1980	Prazosin administration was associated with a significant increase in heart rate and increase in plasma renin activity.	Prazosin	0-8	renin	Canis lupus familiaris	104-109	
7008886-10	1980	We conclude that prazosin is not a unique peripheral vasodilator since hypotensive doses are associated with an increase in heart rate and plasma renin activity.	Prazosin	17-25	renin	Canis lupus familiaris	146-151	
7008886-2	1980	The effect of a hypotensive dose of intravenous prazosin (0.2 mg/kg) on heart rate and plasma renin activity was evaluated in anaesthetized mongrel dogs pretreated with indomethacin.	Prazosin	48-56	renin	Canis lupus familiaris	94-99	
975613-7	1976	Prazosin lowered plasma renin activity to 62% (P less than 0-025) of the control value whereas diazoxide raised plasma renin activity to 178% (P less than 0.05) of the control value.	Prazosin	0-8	renin	Canis lupus familiaris	24-29	
975613-9	1976	The combination of vasodilatation and low renin activity observed following the administration of prazosin is unique, and may have clinical significance if these factors reduce the vascular complications of hypertension.	Prazosin	98-106	renin	Canis lupus familiaris	42-47