PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10524943-8	1999	These contractions to noradrenaline and acetylcholine were competitively inhibited by prazosin (pK(B): 8.38 +/- 0.10) and atropine (pK(B): 8.52 +/- 0.43), respectively.	Prazosin	86-94	AKT serine/threonine kinase 1	Homo sapiens	96-100	
21614555-4	2011	Western blot analysis of phosphorylated proteins showed that exposure to prazosin increased the levels of phospho-p53 and phospho-adenosine monophosphate-activated protein kinase (AMPK) but dramatically decreased the levels of phospho-mammalian target of rapamycin (mTOR), phospho-protein kinase B (Akt), and phospho-ribosomal protein S6 kinase (p70S6K).	Prazosin	73-81	AKT serine/threonine kinase 1	Homo sapiens	299-302	
11481271-9	2001	Schild analyses for the antagonists against brimonidine yielded regression lines with slopes of unity and functional antagonist potencies (pK(B)) for BRL44408 (7.8), ARC 239 (5.8) and for prazosin (6.0) suggesting the presence of functional alpha(2A)-adrenoceptors.	Prazosin	188-196	AKT serine/threonine kinase 1	Homo sapiens	139-144	
11525314-5	2001	Prazosin, cyclazosin, RS-100329 and Ro70-0004/003 antagonized norepinephrine-induced contractile responses with affinity estimates (pK(B) or pA2) of 8.4, 7.3, 9.2 and 8.8, respectively, consistent with the singular involvement of alpha1A-adrenoceptor subtype.	Prazosin	0-8	AKT serine/threonine kinase 1	Homo sapiens	132-137	
11121814-7	2001	Prazosin reduced the maximum responses to brimonidine, shifted the concentration response curves of noradrenaline and phenylephrine rightwards giving pK(B) values of 9.86 and 9.33, respectively.	Prazosin	0-8	AKT serine/threonine kinase 1	Homo sapiens	150-154	
32765662-0	2020	Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway.	Prazosin	0-8	AKT serine/threonine kinase 1	Homo sapiens	123-126	
1679604-3	1991	The affinities (expressed as pKB values) of prazosin for the receptor mediating the responses to phenylephrine were 8.88-9.41, whereas the affinities of yohimbine for the receptor mediating the responses to B-HT 933 were 7.71-7.97.	Prazosin	44-52	AKT serine/threonine kinase 1	Homo sapiens	29-32	
32765662-6	2020	Prazosin-induced apoptosis in U251 and U87 cells was detected by flow cytometry, and the protein expression levels of anti-apoptotic proteins and proteins related to the PI3K/AKT/mTOR signaling pathway were detected by western blotting.	Prazosin	0-8	AKT serine/threonine kinase 1	Homo sapiens	175-178	
32765662-10	2020	Additionally, the expression of phosphorylated (p)-AKT and p-mTOR, P70 and cyclin D1 were decreased in U251 and U81 cells following prazosin treatment (P<0.05).	Prazosin	132-140	AKT serine/threonine kinase 1	Homo sapiens	51-54	
32765662-11	2020	The present study suggested that prazosin may suppress glioblastoma progression by downregulating the activity of the PI3K/AKT/mTOR signaling pathway.	Prazosin	33-41	AKT serine/threonine kinase 1	Homo sapiens	123-126	
31954876-6	2020	The activation of PI3K/Akt/mTOR signaling pathway was significantly suppressed by prazosin via reducing the phosphorylation of Akt and mTOR.	Prazosin	82-90	AKT serine/threonine kinase 1	Homo sapiens	23-26	
31954876-6	2020	The activation of PI3K/Akt/mTOR signaling pathway was significantly suppressed by prazosin via reducing the phosphorylation of Akt and mTOR.	Prazosin	82-90	AKT serine/threonine kinase 1	Homo sapiens	127-130	
31954876-10	2020	CONCLUSION: These results highlight an anti-cancer activity of prazosin on AML by inhibiting the PI3K/Akt/mTOR pathway and targeting TNS1.	Prazosin	63-71	AKT serine/threonine kinase 1	Homo sapiens	102-105	
27138566-0	2016	The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCdelta-dependent inhibition of the AKT pathway.	Prazosin	27-35	AKT serine/threonine kinase 1	Homo sapiens	110-113