PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26037245-1	2016	Evidence suggests that the norepinephrine system represents an important treatment target for alcohol dependence (AD) and the alpha1 -blocker prazosin may reduce alcohol drinking in rodents and alcoholic patients.	Prazosin	142-150	adrenoceptor alpha 1D	Homo sapiens	126-132	
27016578-7	2016	Prazosin was effective to induce alpha1-blockade since phenylephrine-induced increases in MAP were greatly reduced (P < 0.05).	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	33-39	
25093677-5	2015	The present study examined the effect of a short-acting selective alpha1 antagonist (prazosin) on autonomic dysreflexia severity using a randomized placebo trial during medically supervised penile vibrostimulation in six males with cervical spinal cord injury.	Prazosin	85-93	adrenoceptor alpha 1D	Homo sapiens	66-72	
24456374-7	2014	The alpha1 adrenergic antagonist prazosin is currently under investigation in alcohol dependence with and without comorbid posttraumatic stress disorder (PTSD).	Prazosin	33-41	adrenoceptor alpha 1D	Homo sapiens	4-10	
25174978-3	2014	These compounds have shown better activity than reference drug Prazosin (which acts as anti-hypertensive agent by alpha1 blocking action).	Prazosin	63-71	adrenoceptor alpha 1D	Homo sapiens	114-120	
23266935-8	2013	NA enhanced inhibition in MCs across a broad concentration range (0.1-30 muM) and its effects were completely abolished by a mixture of alpha1- and beta-AR antagonists (1 muM prazosin and 10 muM propranolol).	Prazosin	175-183	adrenoceptor alpha 1D	Homo sapiens	136-155	
24825992-3	2010	The discovery of prazosin, with very high index of alpha1/alpha2 affinity has triggered off a renaissance of interest in alpha1-adrenoceptor antagonist drugs for treatment of hypertension.	Prazosin	17-25	adrenoceptor alpha 1D	Homo sapiens	51-64	
18187928-2	2008	Our results indicate that the amino acids Asp176 in the third transmembrane domain (TMD), Glu237 in TMD IV, and Ser258 in TMD V of alpha(1d)-AR were directly involved in prazosin and tamsulosin binding.	Prazosin	170-178	adrenoceptor alpha 1D	Homo sapiens	131-143	
15678090-0	2005	Addition of a signal peptide sequence to the alpha1D-adrenoceptor gene increases the density of receptors, as determined by [3H]-prazosin binding in the membranes.	Prazosin	129-137	adrenoceptor alpha 1D	Homo sapiens	45-65	
17103145-4	2006	The contractions to 5-HT were competitively antagonized by the 5-HT(2A) receptor antagonist ketanserin, whilst those to noradrenaline were antagonized by alpha(1)-(prazosin), alpha(2)-(rauwolscine and yohimbine) and alpha(2C/2B)-(OPC-28326) adrenoceptor antagonists.	Prazosin	164-172	adrenoceptor alpha 1D	Homo sapiens	154-162	
17959849-4	2007	The concentration-dependent contraction to noradrenaline (10(-8) to 10(-4) M) was similar in hepatic and mesenteric arteries, and prazosin (alpha 1-adrenergic antagonist, 10(-6) M), but not yohimbine (alpha 2-adrenergic antagonist, 10(-6) M), produced a rightward parallel displacement of this contraction in both types of arteries.	Prazosin	130-138	adrenoceptor alpha 1D	Homo sapiens	140-147	
15608085-11	2005	In mesenteric arteries, constriction to phenylpropanolamine was not affected by the selective alpha2-adrenergic antagonist, rauwolscine (10(-7) M) but was abolished by the selective alpha1-adrenergic antagonist, prazosin (3 x 10(-7) M).	Prazosin	212-220	adrenoceptor alpha 1D	Homo sapiens	182-188	
15678090-15	2005	This indicates that the low expression level of [3H]-prazosin binding sites, after transfection with the wild-type alpha1D-adrenoceptor, is not caused by constitutive activity of the receptor and subsequent receptor downregulation.	Prazosin	53-61	adrenoceptor alpha 1D	Homo sapiens	115-135	
12967060-3	2003	Nine older men with chronic PTSD secondary to military or Holocaust trauma were prescribed the lipophilic alpha-1 adrenergic antagonist prazosin for treatment-resistant trauma-related nightmares.	Prazosin	136-144	adrenoceptor alpha 1D	Homo sapiens	106-113	
10692482-0	2000	Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor.	Prazosin	47-55	adrenoceptor alpha 1D	Homo sapiens	91-120	
12515754-9	2003	CONCLUSIONS: The alpha1-blockers doxazosin and prazosin induce the apoptosis of cardiomyocytes cultured in vitro by a mechanism that is independent of alpha1 blockade and calcineurin.	Prazosin	47-55	adrenoceptor alpha 1D	Homo sapiens	17-23	
12515754-9	2003	CONCLUSIONS: The alpha1-blockers doxazosin and prazosin induce the apoptosis of cardiomyocytes cultured in vitro by a mechanism that is independent of alpha1 blockade and calcineurin.	Prazosin	47-55	adrenoceptor alpha 1D	Homo sapiens	151-157	
11394731-1	2001	BACKGROUND: Treatment of benign prostatic hyperplasia (BPH) with nonselective alpha1 antagonists such as terazosin, doxazosin, and prazosin results in blood pressure reduction due to vasodilation.	Prazosin	131-139	adrenoceptor alpha 1D	Homo sapiens	78-84	
11178831-3	2001	The alpha-1 antagonist prazosin was synthesized, as well as several other examples, in good yields and purity.	Prazosin	23-31	adrenoceptor alpha 1D	Homo sapiens	4-11	
8730513-3	1996	The rapid and large [Ca+]i response, which was inhibited by 90% by the alpha 1-antagonist prazosin and only by 20% by the non-specific beta antagonist (-)-propranolol, was considered to be mediated by the alpha 1-adrenoceptor.	Prazosin	90-98	adrenoceptor alpha 1D	Homo sapiens	71-78	
9799400-7	1998	Prazosin, a specific alpha1-antagonist, reduced or eliminated the inhibition by Epi, but the response pattern suggests a low affinity.	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	21-27	
8730513-3	1996	The rapid and large [Ca+]i response, which was inhibited by 90% by the alpha 1-antagonist prazosin and only by 20% by the non-specific beta antagonist (-)-propranolol, was considered to be mediated by the alpha 1-adrenoceptor.	Prazosin	90-98	adrenoceptor alpha 1D	Homo sapiens	205-212	
7950979-9	1994	The PhE-effect was inhibited by the alpha 1-antagonist prazosin, but not by the beta-antagonist atenolol.	Prazosin	55-63	adrenoceptor alpha 1D	Homo sapiens	36-43	
7498294-3	1995	The alpha 1-adrenoceptor antagonist prazosin antagonized the contraction elicited by noradrenaline and phenylephrine.	Prazosin	36-44	adrenoceptor alpha 1D	Homo sapiens	4-11	
7898647-1	1994	Alpha-1 and alpha-2 adrenergic receptors were localized in developing cat visual cortex by using [3H]prazosin and [3H]rauwolscine, respectively as selective ligands.	Prazosin	97-109	adrenoceptor alpha 1D	Homo sapiens	0-7	
7562595-6	1995	Pretreatment with the alpha-1 adrenoceptor blocker prazosin antagonized the DS effects of cocaine under both training conditions as well as the cocaine-like effects of talsupram and tomoxetine, but not GBR 12909, under the low-dose training condition.	Prazosin	51-59	adrenoceptor alpha 1D	Homo sapiens	22-29	
8697903-3	1995	On the other hand, the Ki values of prazosin for alpha 1- and alpha 2-adrenoceptors were about 0.19 (nM) and 4.8 (microM), respectivity.	Prazosin	36-44	adrenoceptor alpha 1D	Homo sapiens	49-56	
7824541-3	1994	With the antagonists, object pecking was suppressed more by prazosin (alpha 1) and propranolol (beta) than by yohimbine (alpha 2), while drinker-directed activity showed delayed stimulation with yohimbine and propranolol.	Prazosin	60-68	adrenoceptor alpha 1D	Homo sapiens	70-77	
1373456-4	1992	The potency of alpha-1 antagonists in the order prazosin greater than bunazosin greater than alfuzosin greater than urapidil greater than terazosin and that of alpha-2 antagonists is urapidil greater than alfuzosin greater than terazosin greater than bunazosin greater than prazosin.	Prazosin	48-56	adrenoceptor alpha 1D	Homo sapiens	15-22	
8384425-5	1993	In support of this explanation, we found that approximately 50% of the vasoconstrictor effect of sympathetic nerve stimulation (8 Hz) was blocked by prazosin, an alpha 1-adrenergic antagonist, but no further diminution of tone was seen with addiction of yohimbine, an alpha 2-adrenergic antagonist.	Prazosin	149-157	adrenoceptor alpha 1D	Homo sapiens	162-169	
1373456-4	1992	The potency of alpha-1 antagonists in the order prazosin greater than bunazosin greater than alfuzosin greater than urapidil greater than terazosin and that of alpha-2 antagonists is urapidil greater than alfuzosin greater than terazosin greater than bunazosin greater than prazosin.	Prazosin	274-282	adrenoceptor alpha 1D	Homo sapiens	15-22	
1980236-3	1990	alpha 1-Adrenergic receptors have a high affinity for drugs such as prazosin, doxazosin, and terazosin, which act to reduce blood pressure by selective blockade of the receptor.	Prazosin	68-76	adrenoceptor alpha 1D	Homo sapiens	0-7	
1350488-6	1992	Selective alpha 1-antagonists (prazosin, doxazosin) are preferable to the older nonselective compounds like phentolamine.	Prazosin	31-39	adrenoceptor alpha 1D	Homo sapiens	10-17	
1354322-5	1992	The non-selective alpha adrenoceptor antagonist phentolamine produced a dose-dependent antagonism of the pressor effect of cocaine, as did the alpha-1 selective antagonist prazosin.	Prazosin	172-180	adrenoceptor alpha 1D	Homo sapiens	143-150	
1687712-5	1991	Examples of this class of drugs are prazosin, indoramin, and an analogous of prazosin, doxazosin, which has a high antagonist and selective action for post-synaptic alpha-1 adrenergic receptors and a longer half-life.	Prazosin	36-44	adrenoceptor alpha 1D	Homo sapiens	165-172	
1687712-5	1991	Examples of this class of drugs are prazosin, indoramin, and an analogous of prazosin, doxazosin, which has a high antagonist and selective action for post-synaptic alpha-1 adrenergic receptors and a longer half-life.	Prazosin	77-85	adrenoceptor alpha 1D	Homo sapiens	165-172	
1378144-14	1992	For a comparable antihypertensive action, however, the alpha 1-blocking effect is less pronounced than that of an alpha 1-blocker such as prazosin.	Prazosin	138-146	adrenoceptor alpha 1D	Homo sapiens	114-121	
1860188-6	1991	Of the antagonists, when tested alone, only the selective alpha 1-antagonist prazosin had a direct effect on cochlear blood flow, demonstrating an increase in cochlear blood flow.	Prazosin	77-85	adrenoceptor alpha 1D	Homo sapiens	58-65	
1726720-3	1991	In the inhibition experiment selective alpha-1 antagonists, prazosin and terazosin inhibited the 3H-prazosin or 3H-yohimbine bindings to prostatic adenomas.	Prazosin	60-68	adrenoceptor alpha 1D	Homo sapiens	39-46	
1726720-4	1991	The ability as alpha-1 antagonist is ten times greater in prazosin than in terazosin, but that as alpha-2 antagonist is greater in terazosin than in prazosin.	Prazosin	58-66	adrenoceptor alpha 1D	Homo sapiens	15-22	
1726720-4	1991	The ability as alpha-1 antagonist is ten times greater in prazosin than in terazosin, but that as alpha-2 antagonist is greater in terazosin than in prazosin.	Prazosin	149-157	adrenoceptor alpha 1D	Homo sapiens	15-22	
2171353-4	1990	Competition experiments with alpha 1- and alpha 2-adrenergic selective antagonists (prazosin and yohimbine, respectively) demonstrated high- and low-affinity sites for each antagonist, indicating the presence of both receptor subtypes.	Prazosin	84-92	adrenoceptor alpha 1D	Homo sapiens	29-49	
1983458-3	1990	The effects of noradrenaline microinjection (30 nmol in 1 microliter) into the LHA on urinary sodium excretion (UNaV) are blocked by previous injection of the alpha-1 antagonist prazosin (4 nmol in 1 microliter) from 3.22 +/- 0.25 to 0.59 +/- 0.04 microEq min-1 100 g body weight-1.	Prazosin	178-186	adrenoceptor alpha 1D	Homo sapiens	159-166	
2156732-3	1990	The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor.	Prazosin	88-96	adrenoceptor alpha 1D	Homo sapiens	58-65	
1980655-4	1990	The stimulated tritium release was inhibited by yohimbine (alpha 2-antagonist), and increased by phentolamine (alpha-antagonist) and prazosin (alpha 1-antagonist).	Prazosin	133-141	adrenoceptor alpha 1D	Homo sapiens	143-150	
1968249-8	1990	The rank order of IC50corr values for norepinephrine, clonidine, yohimbine, terazosin, and prazosin indicated that doxazosin binds selectively to alpha 1 and alpha 2 adrenergic binding sites.	Prazosin	91-99	adrenoceptor alpha 1D	Homo sapiens	146-165	
1983458-6	1990	Our results indicate that natriuresis occurs even in the absence of changes in glomerular filtration rate and demonstrate an inhibitory natriuretic effect of an alpha-1 blocker (prazosin) injected into the LHA before adrenaline, while an alpha-2 antagonist (yohimbine) yielded a potentiating effect.	Prazosin	178-186	adrenoceptor alpha 1D	Homo sapiens	161-168	
2570572-3	1989	The response was diminished in the absence of extracellular Ca2+ and was inhibited more efficiently by phentolamine and prazosin than by propranolol or yohimbine, indicating alpha 1-adrenergic mediation.	Prazosin	120-128	adrenoceptor alpha 1D	Homo sapiens	174-181	
2473223-2	1989	The binding of selective alpha-1 and alpha-2 ligands, [3H]-prazosin and [3H]-UK 14,304, to homogenates of human central and peripheral prostate was saturable and of high affinity.	Prazosin	59-67	adrenoceptor alpha 1D	Homo sapiens	25-32	
2548381-6	1989	Likewise, in a variety of species, alpha 1-adrenergic inhibition with prazosin markedly decreases the incidence of malignant ventricular arrhythmias associated with either myocardial ischemia or subsequent reperfusion.	Prazosin	70-78	adrenoceptor alpha 1D	Homo sapiens	35-42	
2666677-6	1989	Total alpha-adrenergic blockade with phenoxybenzamine versus selective (alpha 1) blockage with prazosin are equally effective preoperatively.	Prazosin	95-103	adrenoceptor alpha 1D	Homo sapiens	72-79	
2906698-3	1988	Prazosin and its successor drugs doxazosin, trimazosin and terazosin are the prototypes of selective alpha 1-adrenoceptor antagonists.	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	101-108	
2577457-3	1989	Three alpha 1-inhibitors are reviewed in this article: prazosin, terazosin, and doxazosin.	Prazosin	55-63	adrenoceptor alpha 1D	Homo sapiens	6-13	
2571433-2	1989	Alpha-1 antagonists such as prazosin have favorable effects on plasma lipids but may produce excessive postural falls in blood pressure, particularly following the initial dose.	Prazosin	28-36	adrenoceptor alpha 1D	Homo sapiens	0-7	
2571433-3	1989	Recently developed alpha-1 antagonists (doxazosin, terazosin) have longer durations of action than prazosin, allowing less frequent administration.	Prazosin	99-107	adrenoceptor alpha 1D	Homo sapiens	19-26	
2540318-7	1989	Prazosin (selective alpha-1 adrenergic antagonist) depressed both the slope and maximal response of the control curve for norepinephrine but the shift was not significant.	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	20-27	
2477832-5	1989	The IC50 for the inhibition of phenylephrine-induced contractions by prazosin was 3.2 nM, confirming that phenylephrine-induced contraction in the human prostate is mediated by the alpha 1 adrenoceptor.	Prazosin	69-77	adrenoceptor alpha 1D	Homo sapiens	181-188	
2569215-6	1989	The noradrenergic alpha-1 antagonist prazosin (0.3-3.0 mg/kg) blocked the behavioral effects of 3.0 mg/kg MDMA at doses that did not attenuate MDA"s rate-decreasing effects.	Prazosin	37-45	adrenoceptor alpha 1D	Homo sapiens	18-25	
2905005-3	1988	Prazosin, a selective alpha-1 antagonist, produced a parallel shift of the concentration response curve to phenylephrine, a selective alpha-1 agonist, with no significant reduction in the maximal response.	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	22-29	
2905005-3	1988	Prazosin, a selective alpha-1 antagonist, produced a parallel shift of the concentration response curve to phenylephrine, a selective alpha-1 agonist, with no significant reduction in the maximal response.	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	134-141	
2902880-8	1988	The alpha 2-adrenoceptor antagonist yohimbine is more effective than the alpha 1-antagonist prazosin for blocking the stimulation of epithelial transport.	Prazosin	92-100	adrenoceptor alpha 1D	Homo sapiens	73-80	
3236799-0	1988	[A case of intolerance to the adrenergic alpha1 blockader prazosin].	Prazosin	58-66	adrenoceptor alpha 1D	Homo sapiens	41-47	
3170423-7	1988	The alpha 1-agonist aerosol prazosin shifted the phenylephrine dose-response curves to the right, but prasozin did not bronchodilate the principals during period B.	Prazosin	28-36	adrenoceptor alpha 1D	Homo sapiens	4-11	
2879884-0	1987	Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: competition studies with [3H]prazosin and [3H]idazoxan.	Prazosin	86-98	adrenoceptor alpha 1D	Homo sapiens	0-7	
3035948-5	1987	alpha 1-Adrenergic receptor blockade with prazosin (0.5 mg/kg, n = 10) inhibited the sympathetic vasoconstriction in the cerebrum, hippocampus, and masseter muscle (7 +/- 2, 4 +/- 3, and 55 +/- 9%, respectively) and abolished it in the choroid plexus.	Prazosin	42-50	adrenoceptor alpha 1D	Homo sapiens	0-7	
3033211-5	1987	In proximal and distal arteries, alpha-1 adrenergic blockade with prazosin produced a nonparallel shift in the concentration-effect curve to high compared to low concentrations of the agonist.	Prazosin	66-74	adrenoceptor alpha 1D	Homo sapiens	33-40	
2879884-1	1987	The tritiated adrenergic antagonists prazosin ([3H]PRZ) and idazoxan ([3H]IDA, or RX-781094) bind specifically and with high affinity in membrane preparations from cerebral cortex to alpha-1- and alpha-2-adrenoceptors respectively.	Prazosin	37-45	adrenoceptor alpha 1D	Homo sapiens	183-190	
3014117-2	1986	To learn the sensitivity of the Schild plot as a test for the presence of more than one receptor type in such tissues, we constructed the plots to be expected from the dissociation constants of l-norepinephrine and prazosin for alpha-1 and alpha-2 adrenoceptors, using values determined by radioligand methods, and examining the effects of varying the proportions of the two types.	Prazosin	215-223	adrenoceptor alpha 1D	Homo sapiens	228-235	
3020816-2	1986	Therefore, the tocolytic effect of prazosin, which is supposed to be the most potent alpha 1 blocking agent, was investigated in myometrial strips.	Prazosin	35-43	adrenoceptor alpha 1D	Homo sapiens	85-92	
3007555-9	1986	The maximum number of binding sites for the binding of [3H]prazosin and [3H]dihydroergocryptine were the same (60-70 fmol/mg protein), indicating that the majority of the alpha-receptors are of the alpha 1-subtype.	Prazosin	55-67	adrenoceptor alpha 1D	Homo sapiens	198-205	
3007555-10	1986	Competition experiments with prazosin and yohimbine confirmed the predominance of the alpha 1-receptor subtype, although the presence of alpha 2-receptors cannot be completely ruled out.	Prazosin	29-37	adrenoceptor alpha 1D	Homo sapiens	86-93	
2859092-9	1985	Both the alpha-1 antagonist, prazosin, and the alpha-2 agonist, clonidine, produced an increase in nociceptive threshold.	Prazosin	29-37	adrenoceptor alpha 1D	Homo sapiens	9-16	
2992273-4	1985	Studies in which prazosin, an alpha 1-antagonist, and yohimbine, and alpha 2-antagonist, competed for [3H] dihydroergocryptine binding sites in human myometrium indicated that approximately 70% are alpha 2-receptors and that 30% are alpha 1-receptors.	Prazosin	17-25	adrenoceptor alpha 1D	Homo sapiens	233-240	
2995067-7	1985	In addition, the adrenoceptor antagonists prazosin (alpha 1) and propranolol (beta) as well as the dopamine receptor antagonist haloperidol had significant but less potent - protective actions upon kainic acid-induced seizures and subsequent neurochemical changes.	Prazosin	42-50	adrenoceptor alpha 1D	Homo sapiens	52-59	
2871065-3	1985	In both preparations lysine-vasopressin (LVP) and epinephrine (EPI) stimulated ACTH secretion; prazosin (alpha-1 blocker) inhibited the EPI but not the LVP-mediated stimulation.	Prazosin	95-103	adrenoceptor alpha 1D	Homo sapiens	105-112	
2991614-5	1985	Comparison of pA2 values of prazosin and yohimbine in both the tissues with those values found in the literature for these compounds in a variety of tissues containing alpha-1 or alpha-2 adrenergic receptor indicates that the postsynaptic alpha adrenergic receptor subtype in the human urinary bladder base and prostatic urethra is the alpha-1 type, not the alpha-2 type.	Prazosin	28-36	adrenoceptor alpha 1D	Homo sapiens	168-175	
2579826-2	1985	The contractile response induced by norepinephrine in this tissue could be antagonized by prazosin, a selective alpha 1-antagonist, with a receptor dissociation constant (KB) of 4.0 +/- 0.9 nM.	Prazosin	90-98	adrenoceptor alpha 1D	Homo sapiens	112-119	
6313273-6	1983	Alpha 1-Adrenoceptor blockade by prazosin increased forearm blood flow by 122.7 +/- 33.8% and combined alpha 1 and alpha 2 blockade by phentolamine by 127.2 +/- 29.9%, indicating much the same degree of postjunctional alpha-adrenoceptor blockade.	Prazosin	33-41	adrenoceptor alpha 1D	Homo sapiens	0-7	
6150925-7	1984	Prazosin, an alpha 1-selective blocking agent, evokes peripheral vasodilation with less reflex tachycardia than does the nonselective alpha 1-alpha 2 blocker phentolamine, probably because the former spares the prejunctional alpha 2-receptors that subserve autoinhibition of norepinephrine release from the sympathetic neuron.	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	13-20	
6142878-9	1984	Acute alpha 1-blockade with prazosin induces reflex elevation of catecholamines, which in the absence of blockade of hepatic beta 2-receptors produces elevation of plasma glucose.	Prazosin	28-36	adrenoceptor alpha 1D	Homo sapiens	6-13	
6702866-11	1984	Acute alpha 1-blockade with prazosin induces reflex elevation of catecholamine levels.	Prazosin	28-36	adrenoceptor alpha 1D	Homo sapiens	6-13	
6142395-7	1984	On the other hand, prazosine (alpha 1-type antagonist) blocked the stimulatory effect of epinephrine and norepinephrine on AC system.	Prazosin	19-28	adrenoceptor alpha 1D	Homo sapiens	30-37	
32022675-0	2020	Alpha-1 adrenergic-antagonists use increases the risk of sleep apnea: implications for understanding the role of prazosin in PTSD.	Prazosin	113-121	adrenoceptor alpha 1D	Homo sapiens	0-7	
6301291-6	1983	Excitatory junction potentials are antagonized by the alpha 1-blocker prazosin.	Prazosin	70-78	adrenoceptor alpha 1D	Homo sapiens	54-61	
7023221-2	1981	Prazosin and trimazosin are selective alpha 1-blockers that cause a balanced increase in cardiac output (CO) and reduction in left ventricular filling pressure (LVFP); the reduction in diastolic blood pressure with these drugs is significantly related to increase in treadmill exercise, fall in LVFP, and increase in CO. Pirbuterol is a relatively selective beta 2-agonist with somewhat greater effects on CO than on LVFP.	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	38-45	
6124632-2	1982	Prazosin, WB-4101 and corynanthine were found to be effective central alpha-1 adrenoceptor antagonists and piperoxane, yohimbine and rauwolscine were found to be effective central alpha-2 adrenoceptor antagonists.	Prazosin	0-8	adrenoceptor alpha 1D	Homo sapiens	70-77	
6279501-0	1982	Antibodies to the alpha 1- and alpha 2-selective antagonists prazosin and yohimbine as probes of the alpha-adrenergic binding sites.	Prazosin	61-69	adrenoceptor alpha 1D	Homo sapiens	18-38	
6279501-2	1982	Competitive inhibition of [3H]prazosin binding to anti-CP57,609 antiserum by a variety of unlabeled ligands revealed a spectrum of antibody specificity, with alpha 1-selective agents competing more potently than alpha 2-selective ligands.	Prazosin	26-38	adrenoceptor alpha 1D	Homo sapiens	158-165	
6121823-2	1982	Yohimbine, an alpha-2 adrenoceptor antagonist, markedly reduced epinephrine-stimulated 3H-glycerol uptake into phosphatidylinositol; while prazosin, an alpha-1 antagonist, was without effect.	Prazosin	139-147	adrenoceptor alpha 1D	Homo sapiens	152-159	
30287134-7	2018	: Because of the increasing exposure of children to prazosin, clinicians should be aware of the pharmacology behind alpha-1 antagonist overdose and consider treatment options, such as vasopressin, when hypotension is resistant to standard fluid and catecholamine therapy.	Prazosin	52-60	adrenoceptor alpha 1D	Homo sapiens	116-123	
28755207-2	2017	The alpha-1 antagonist prazosin reduces sleep disturbances and nightmares in adults with PTSD; however, its use in youth with PTSD has not been systematically evaluated.	Prazosin	23-31	adrenoceptor alpha 1D	Homo sapiens	4-11