PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16165282-6 2005 Prazosin attenuated stress-induced plasma IL-1beta and IL-6, but had no effect on tissue IL-1beta levels, while propranolol attenuated plasma IL-6 and blocked tissue IL-1beta elevation, and labetalol, which cannot cross the blood-brain barrier, attenuated plasma IL-1beta and IL-6, blocked pituitary IL-1beta, but had no effect on central tissue IL-1beta levels. Prazosin 0-8 interleukin 6 Rattus norvegicus 55-59 33559503-11 2021 Moreover, treatment with prazosin inhibited renal NF-kappaB activation, resulting in a significant decline in pro-inflammatory cytokine of IL-6. Prazosin 25-33 interleukin 6 Rattus norvegicus 139-143 9277562-3 1997 A modest inhibition of the IL-1 beta-induced plasma IL-6 production was observed following pretreatment with prazosin (20 micrograms/rat i.c.v.) Prazosin 109-117 interleukin 6 Rattus norvegicus 52-56 12619890-10 2003 It further increased up to 48 h. The effect of NE on IL-6 mRNA was abolished by the beta-adrenoceptor blockers propranolol, metoprolol (beta1) and ICI 118.551 (beta2), but not by the alpha-adrenoceptor blockers prazosin (alpha1) and yohimbine (alpha2). Prazosin 211-219 interleukin 6 Rattus norvegicus 53-57 9227603-7 1997 Whereas prazosin and yohimbine attenuated the increases in plasma IL-6 caused by LPS, phentolamine completely blocked the peripheral effects of central LPS. Prazosin 8-16 interleukin 6 Rattus norvegicus 66-70