PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2164099-0	1990	Pharmacologic activity of prazosin is decreased by alpha-1-acid glycoprotein in vivo.	Prazosin	26-34	orosomucoid 1	Rattus norvegicus	51-76	
2164099-2	1990	This study, however, reports that the alpha-1 adrenergic blocking activity of prazosin is lower in the presence than in the absence of the plasma protein alpha-1-acid glycoprotein (AAG), at the same unbound concentrations.	Prazosin	78-86	orosomucoid 1	Rattus norvegicus	154-179	
2164099-2	1990	This study, however, reports that the alpha-1 adrenergic blocking activity of prazosin is lower in the presence than in the absence of the plasma protein alpha-1-acid glycoprotein (AAG), at the same unbound concentrations.	Prazosin	78-86	orosomucoid 1	Rattus norvegicus	181-184	
2164099-5	1990	The effect vs. log unbound concentration relationships were right-shifted in the presence of AAG both after intravenous bolus doses (160 micrograms/kg) and during intravenous infusion (0.6-2.4 micrograms/min/kg), i.e., AAG decreased the activity of unbound prazosin.	Prazosin	257-265	orosomucoid 1	Rattus norvegicus	93-96	
3598910-0	1987	Decreased elimination of unbound prazosin in the presence of alpha 1-acid glycoprotein in the rat in vivo.	Prazosin	33-41	orosomucoid 1	Rattus norvegicus	61-86	
3598910-4	1987	Administration of 40 and 100 mg/kg of AAG decreased the unbound fraction in plasma of prazosin from 0.238 to 0.175 and 0.090, respectively.	Prazosin	86-94	orosomucoid 1	Rattus norvegicus	38-41	
3598910-5	1987	Administration of 40 mg/kg of AAG decreased the clearance of prazosin with respect to unbound drug (CLu) on the average by 40%.	Prazosin	61-69	orosomucoid 1	Rattus norvegicus	30-33	
3598910-9	1987	Because prazosin is a low-to-medium extraction ratio compound in the rat, this decrease in CLu indicates that AAG has an inhibitory effect on the elimination of prazosin that goes beyond a simple protein binding effect.	Prazosin	8-16	orosomucoid 1	Rattus norvegicus	110-113	
3598910-9	1987	Because prazosin is a low-to-medium extraction ratio compound in the rat, this decrease in CLu indicates that AAG has an inhibitory effect on the elimination of prazosin that goes beyond a simple protein binding effect.	Prazosin	161-169	orosomucoid 1	Rattus norvegicus	110-113