PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17710629-0 2007 Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle. Prazosin 41-49 angiotensinogen Rattus norvegicus 0-14 22136253-5 2012 METHODS: To corroborate this speculation, we screened prototypical alpha(1)-antagonists such as prazosin, doxazosin, and terazosin for antagonism of angiotensin II on rat aortic strips. Prazosin 96-104 angiotensinogen Rattus norvegicus 149-163 22136253-7 2012 RESULTS: To our astonishment, we found that prazosin and its analogs which have been reported to have alpha(1)-antagonistic activity only, were able to shift concentration response curves of angiotensin II. Prazosin 44-52 angiotensinogen Rattus norvegicus 191-205 21446059-2 2011 This effect is not associated with activation of alpha1-adrenoceptors by 8-OH-DPAT as it is reproduced in the presence of prazosin which completely suppresses the nonspecific vasoconstrictive effect of 8-OH-DPAT via alpha1-adrenoceptors on the aorta incubated without angiotensin II. Prazosin 122-130 angiotensinogen Rattus norvegicus 268-282 17710629-6 2007 Maintenance of ANGII levels restored prazosin-induced angiogenesis in animals fed a high-salt diet. Prazosin 37-45 angiotensinogen Rattus norvegicus 15-20 15613065-6 2005 Presence of prazosin, ifetroban, or PD145065 in perfusion media reduced (P < 0.05) Ang II maximal response in all groups. Prazosin 12-20 angiotensinogen Rattus norvegicus 86-92 15613065-7 2005 Maximal inhibition of Ang II-induced vasoconstriction produced by the 3 antagonists was comparable in untreated WKY, but that of ifetroban and PD145065 was lower (P < 0.05) than that of prazosin in untreated SHR. Prazosin 189-197 angiotensinogen Rattus norvegicus 22-28 8960880-11 1996 The alpha 1-adrenoceptor antagonist prazosin also diminished the pressor and renal and mesenteric vasoconstrictor responses produced by angiotensin II. Prazosin 36-44 angiotensinogen Rattus norvegicus 136-150 12376412-7 2002 Peripheral treatment with prazosin abolished the hypotensive effect of ANG-(1-7) and ANG II. Prazosin 26-34 angiotensinogen Rattus norvegicus 85-91 12235268-9 2002 This effect was confirmed with assays that showed a relaxant response induced by Ang II on precontracted tissues incubated with prazosin. Prazosin 128-136 angiotensinogen Rattus norvegicus 81-87 12185387-5 2002 Pretreatment with 80 nmol/ micro l yohimbine or prazosin into the MSA also reduced the ANGII-induced water intake (3.0 +/- 0.4 and 3.1 +/- 0.2 ml/120 min, respectively). Prazosin 48-56 angiotensinogen Rattus norvegicus 87-92 12185387-6 2002 Yohimbine + prazosin + clonidine injected into the MSA abolished the ANGII-induced water intake (0.2 +/- 0.1 and 0.2 +/- 0.1 ml/120 min, respectively). Prazosin 12-20 angiotensinogen Rattus norvegicus 69-74 12185387-13 2002 Prazosin + clonidine attenuated the inhibitory effects of ANGII. Prazosin 0-8 angiotensinogen Rattus norvegicus 58-63 11804625-5 2002 Pretreatment with the alpha 1-adrenoceptor antagonist, prazosin, significantly inhibited the Ang II-induced transcription factor expression in the SON and PVN. Prazosin 55-63 angiotensinogen Rattus norvegicus 93-99 11011038-7 2000 Moreover, administration of prazosin during angiotensin II preconditioning or depletion of biogenic amines by reserpinisation (0.5 mg/kg i.p.) Prazosin 28-36 angiotensinogen Rattus norvegicus 44-58 10974488-7 2000 The injection of yohimbine (an alpha-2-adrenergic antagonist) and prazosin (an alpha-1-adrenergic antagonist) into the LH, which was done before injecting ANGII into the LV, also reduced the water intake induced by ANGII. Prazosin 66-74 angiotensinogen Rattus norvegicus 215-220 10974488-10 2000 Previous treatment with prazosin increased the inhibitory effects of ANGII in those parameters. Prazosin 24-32 angiotensinogen Rattus norvegicus 69-74 10974488-11 2000 The injection of yohimbine and prazosin, which was done before the injection of clonidine, attenuated the effect of clonidine on the ANGII mechanism. Prazosin 31-39 angiotensinogen Rattus norvegicus 133-138 7878073-5 1994 Both prazosin and L-arginine reduced the drinking response to administration of angiotensin II. Prazosin 5-13 angiotensinogen Rattus norvegicus 80-94 7633894-3 1995 The dipsogenic response to ICA ANGII (25 ng) was reduced after prazosin (40 nmol) into the MSA. Prazosin 63-71 angiotensinogen Rattus norvegicus 31-36 8746199-9 1995 In the presence of angiotensin II (0.1 nM) the concentration-response curve for UK 14304 was shifted to the right by prazosin with a pKB of 6.36 (SHR) and 6.33 (WKY) and by idazoxan with a pKB of 7.68 (SHR) and 7.65 (WKY). Prazosin 117-125 angiotensinogen Rattus norvegicus 19-33 8206611-4 1994 Prazosin, hydralazine, or L-arginine added to the drinking water all lowered the angiotensin II-induced increase in blood pressure but did not attenuate the increase in fibronectin mRNA expression. Prazosin 0-8 angiotensinogen Rattus norvegicus 81-95 7878073-11 1994 The protective effect of arginine and prazosin in cold-induced hypertension may be related both to their reduction in plasma renin activity and to a reduced responsiveness to angiotensin II, as well as to their abilities to increase the secretion of dopamine. Prazosin 38-46 angiotensinogen Rattus norvegicus 175-189 2579749-9 1985 Peripheral alpha-adrenoceptor blockade with prazosin or ganglion blockade with hexamethonium inhibited the central angiotensin II pressor responses only in combination with vasopressin receptor blockade. Prazosin 44-52 angiotensinogen Rattus norvegicus 115-129 7908853-2 1994 Prazosin (an alpha 1-adrenergic antagonist) antagonized the water ingestion, Na+, K+ and urine excretion induced by ANGII, whereas yohimbine (an alpha 2-adrenergic antagonist) enhanced the Na+, K+ and urine excretion induced by ANGII. Prazosin 0-8 angiotensinogen Rattus norvegicus 116-121 7908853-2 1994 Prazosin (an alpha 1-adrenergic antagonist) antagonized the water ingestion, Na+, K+ and urine excretion induced by ANGII, whereas yohimbine (an alpha 2-adrenergic antagonist) enhanced the Na+, K+ and urine excretion induced by ANGII. Prazosin 0-8 angiotensinogen Rattus norvegicus 228-233 7908853-4 1994 Previous treatment with prazosin reduced the pressor responses to ANGII, whereas yohimbine had opposite effects. Prazosin 24-32 angiotensinogen Rattus norvegicus 66-71 2171000-4 1990 After all doses of prazosin (40, 80 and 120 nmol), AII induced bradycardic responses, but only the 80 and 120 nmol doses of prazosin reduced the pressor responses to AII. Prazosin 124-132 angiotensinogen Rattus norvegicus 166-169 1965048-1 1990 Pretreatment of rats with prazosin (PRA), an alpha 1-adrenergic receptor blocker, abolished the increased rate of learning of conditioned avoidance responses stimulated by intracerebroventricular angiotensin II (AII) administration. Prazosin 26-34 angiotensinogen Rattus norvegicus 196-210 1965048-1 1990 Pretreatment of rats with prazosin (PRA), an alpha 1-adrenergic receptor blocker, abolished the increased rate of learning of conditioned avoidance responses stimulated by intracerebroventricular angiotensin II (AII) administration. Prazosin 26-34 angiotensinogen Rattus norvegicus 212-215 8246129-7 1993 The alpha-1 adrenoceptor antagonist, prazosin (0.7 nmol), injected bilaterally into the SON, significantly reduced the ANG II 100-ng i.c.v.-induced AVP release. Prazosin 37-45 angiotensinogen Rattus norvegicus 119-125 1315633-1 1992 We explored effects of alpha 1-adrenoreceptor blockade with prazosin on the increased vascular smooth muscle cell (SMC) DNA synthesis induced by angiotensin II (Ang II) in rats. Prazosin 60-68 angiotensinogen Rattus norvegicus 145-159 1315633-1 1992 We explored effects of alpha 1-adrenoreceptor blockade with prazosin on the increased vascular smooth muscle cell (SMC) DNA synthesis induced by angiotensin II (Ang II) in rats. Prazosin 60-68 angiotensinogen Rattus norvegicus 161-167 2833189-4 1987 The vasoconstrictor effect of high doses of angiotensin II was depressed by the alpha 1-adrenoceptor antagonist prazosin, but not by the alpha 2-adrenoceptor antagonist yohimbine. Prazosin 112-120 angiotensinogen Rattus norvegicus 44-58 3020993-6 1986 ANG II enhanced jejunal absorption in the presence of prazosin. Prazosin 54-62 angiotensinogen Rattus norvegicus 0-6 17000-3 1977 In contrast, the hypotensive action of prazosin was completely abolished, over a 10(4)-fold dose range, after ganglion or alpha adrenoreceptor blockade, and this agent failed, even in maximal hypotensive doses, to attenuate angiotensin II pressor responses. Prazosin 40-48 angiotensinogen Rattus norvegicus 225-239 6341543-0 1983 Blood pressure dependency on vasopressin and angiotensin II in prazosin-treated conscious normotensive rats. Prazosin 63-71 angiotensinogen Rattus norvegicus 45-59 6341543-7 1983 Blockade of angiotensin II with saralasin (10 micrograms/min) further decreased blood pressure of the prazosin-treated rats by 22 +/- 4 mm Hg (P less than .001). Prazosin 102-110 angiotensinogen Rattus norvegicus 12-26 6341543-10 1983 However, prazosin enhanced the reflex bradycardia induced by angiotensin II (P less than .001). Prazosin 9-17 angiotensinogen Rattus norvegicus 61-75