PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18379048-2	2008	Previous molecular dynamics studies from our laboratory indicated that the amino acids Asp106 in the third transmembrane domain (TMD), Gln167 in TMD IV of alpha 1a-AR were directly involved in prazosin, tamsulosin and KMD-3213 binding.	Prazosin	193-201	adrenoceptor alpha 1A	Homo sapiens	155-166	
25447534-0	2014	Molecular exploration of the alpha(1A)-adrenoceptor orthosteric site: binding site definition for epinephrine, HEAT and prazosin.	Prazosin	120-128	adrenoceptor alpha 1A	Homo sapiens	29-51	
23935897-5	2013	Equilibrium and kinetic binding experiments were used to demonstrate that rho-Da1a, prazosin and HEAT compete at the alpha1A-adrenoceptor.	Prazosin	84-92	adrenoceptor alpha 1A	Homo sapiens	117-137	
21262225-7	2011	In addition, using specific binding experiments, we established that these ions acted as negative allosteric ligands on prazosin/alpha(1A)-adrenoceptor interaction, but in a different manner from the allosteric modulator 5-(N-ethyl-N-isopropyl)-amiloride, suggesting distinct mode of interaction.	Prazosin	120-128	adrenoceptor alpha 1A	Homo sapiens	129-151	
18379048-4	2008	On the other hand, the Gln167Phe mutant alpha 1a-AR showed reduced binding affinity for [3H]prazosin.	Prazosin	88-100	adrenoceptor alpha 1A	Homo sapiens	40-51	
18379048-7	2008	The results provide direct evidence that these amino acid residues are responsible for the interactions between alpha 1a-AR and radioligand [3H]prazosin as well as tamsulosin and KMD-3213.	Prazosin	140-152	adrenoceptor alpha 1A	Homo sapiens	112-123	
9249248-7	1997	For the alpha1A-adrenoceptor, binding studies revealed a pharmacological profile typical for the classically defined alpha1A-adrenoceptor, such that prazosin, RS-17053, WB 4101, 5-methylurapidil, Rec 15/2739 and S-niguldipine all displayed subnanomolar affinity.	Prazosin	149-157	adrenoceptor alpha 1A	Homo sapiens	8-28	
11525314-5	2001	Prazosin, cyclazosin, RS-100329 and Ro70-0004/003 antagonized norepinephrine-induced contractile responses with affinity estimates (pK(B) or pA2) of 8.4, 7.3, 9.2 and 8.8, respectively, consistent with the singular involvement of alpha1A-adrenoceptor subtype.	Prazosin	0-8	adrenoceptor alpha 1A	Homo sapiens	230-250	
10433504-11	1999	Schild analysis revealed that the affinity profile of this AR subtype to antagonists in the clone aH7 had a typical pattern for the alpha1a-AR; high affinity for prazosin and WB 4101, and low affinity for BMY7378 (pA2=9.5, 9.8 and 7.3, respectively).	Prazosin	162-170	adrenoceptor alpha 1A	Homo sapiens	59-61	
9857099-8	1998	These findings prove that alpha1a adrenoceptor-subtype selective antagonists such as (-)-63 may be developed as uroselective agents for an improved treatment of BPH over nonselective alpha1 antagonists such as prazosin and terazosin, with fewer side effects.	Prazosin	210-218	adrenoceptor alpha 1A	Homo sapiens	26-46	
9249248-7	1997	For the alpha1A-adrenoceptor, binding studies revealed a pharmacological profile typical for the classically defined alpha1A-adrenoceptor, such that prazosin, RS-17053, WB 4101, 5-methylurapidil, Rec 15/2739 and S-niguldipine all displayed subnanomolar affinity.	Prazosin	149-157	adrenoceptor alpha 1A	Homo sapiens	117-137	
31067439-3	2019	Evidence is presented that the postulated alpha1L-adrenoceptor is simply the native alpha1A-adrenoceptor at which prazosin has low potency.	Prazosin	114-122	adrenoceptor alpha 1A	Homo sapiens	84-104	
30719698-2	2019	Prazosin has a lower affinity for the lower urinary tract alpha1A -adrenoceptor than alpha1A -adrenoceptors found in other parts of the body.	Prazosin	0-8	adrenoceptor alpha 1A	Homo sapiens	58-79