PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11072104-8 2000 Prazosin reduced FCL(SD)-induced elevations of c-jun and c-fos, but not NGFI-A, mRNA. Prazosin 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 57-62 9259051-5 1996 After balloon injury in rat aorta using in situ hybridization, the catecholamine-induced increase in c-fos mRNA expression in the medial layer was inhibited by the alpha 1 receptor antagonists, prazosin and chloroethylclonidine. Prazosin 194-202 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 101-106 10502313-7 1999 More detailed analysis of the Fos response to 8-OH-DPAT in the medial prefrontal cortex revealed that the effect was attenuated by pretreatment with a combination of the beta(1)- and beta(2)-adrenoceptor antagonists ICI 118551 (4 mg/kg) and metoprolol (4 mg/kg), but not the alpha(1)-adrenoceptor antagonist prazosin (5 mg/kg). Prazosin 308-316 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 30-33 1360316-6 1992 The c-fos-li response to yohimbine was blocked by prior administration of the beta receptor antagonist, dl-propranolol, and to a lesser degree by the alpha-1 antagonist, prazosin. Prazosin 170-178 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 4-9 8748977-4 1995 Induction of c-fos was blocked completely by the alpha 1-adrenergic antagonist prazosin, partially by the alpha 2-adrenergic antagonist yohimbine, and not at all by the beta-adrenergic antagonist propranolol. Prazosin 79-87 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-18 8748977-5 1995 A prazosin inhibition curve showed that 1 nmol/L prazosin inhibited 10 micromol/L norepinephrine induced c-fos expression by 40%. Prazosin 2-10 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 105-110 8748977-5 1995 A prazosin inhibition curve showed that 1 nmol/L prazosin inhibited 10 micromol/L norepinephrine induced c-fos expression by 40%. Prazosin 49-57 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 105-110 8040263-3 1994 Phenylephrine, a selective alpha 1 adrenergic receptor agonist, caused a rapid and transient increase in c-fos mRNA accumulation which was inhibited by prazosin, an alpha 1 receptor antagonist. Prazosin 152-160 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 105-110 31556948-9 2019 RESULTS: Prazosin blocked U50,488-induced reinstatement and decreased U50,488-induced Fos expression in the orbitofrontal cortex, nucleus accumbens core, ventral bed nucleus of the stria terminalis, central and basolateral amygdalar nuclei and ventral tegmental area. Prazosin 9-17 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 86-89 28212941-0 2017 Injections of the of the alpha1-adrenoceptor antagonist prazosin into the median raphe nucleus increase food intake and Fos expression in orexin neurons of free-feeding rats. Prazosin 56-64 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 120-123 28212941-4 2017 For this purpose, we examined the induction of c-Fos immunoreactivity in forebrain structures following injections of the alpha1-adrenoceptor antagonist prazosin into the MnR of free-feeding rats. Prazosin 153-161 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 47-52 21902723-9 2011 In SHR, the number of c-Fos-positive neurons was significantly lower following the administration of prazosin compared with vehicle. Prazosin 101-109 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 22-27 27020784-5 2016 In experiment 2, we determined potential central sites of action by analyzing effects of prazosin (1 mg/kg) on yohimbine (1.25 mg/kg)-induced Fos expression. Prazosin 89-97 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 142-145 27020784-8 2016 Systemic prazosin reduced yohimbine-induced Fos expression in the prefrontal cortex, accumbens shell, ventral bed nucleus of the stria terminalis, and basolateral amygdala (46-67 % decreases). Prazosin 9-17 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 44-47 19225867-5 2009 Increases in c-Fos and c-Jun gene expression due to NE were attenuated by both prazosin and a PLC inhibitor, U73122. Prazosin 79-87 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-18 20888358-6 2011 This dose of prazosin (1.0 mg/kg) was then administered 30 min prior to VCS or control scapular stimulation (CSS) and Fos-IR was examined in the posterodorsal medial amygdala (MeaPD), the medial preoptic area (mPOA), and the rostral ventromedial hypothalamus (rVMH). Prazosin 13-21 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 118-121 20888358-8 2011 Prazosin treatment inhibited the increase in Fos-IR in the mPOA and MeaPD but not in the rVMH. Prazosin 0-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 45-48 21525724-0 2011 Effect of long-term prazosin and yohimbine administration on c-Fos expression in spinal neurons: inhibitory effect of alpha-1 and alpha-2 adrenoceptors on afferents from the lower urinary tract. Prazosin 20-28 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 61-66 21525724-6 2011 The numbers of c-Fos-positive neurons in the dorsal horn were significantly lower in rats that received prazosin than in controls. Prazosin 104-112 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 15-20 12955385-6 2003 Pretreatment with the alpha1-adrenergic-receptor antagonist Prazosin or lesion of the serotonergic system significantly reduced the locomotor hyperactivity and striatal Fos expression induced by Amphetamine. Prazosin 60-68 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 169-172 15955417-5 2005 Pretreatment with prazosin (5 mg/kg) effectively suppressed the Fos expression induced by LPS (5 microg/kg), whereas L-NAME (30 mg/kg) did not influence the Fos expression in the AVP neurons induced by LPS (0.25, 0.5, 1, 5 microg/kg). Prazosin 18-26 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 64-67 12459672-7 2002 N2O exposure induced c-Fos expression in the spinal cord, which was blocked by prazosin and naloxone but not by other drugs. Prazosin 79-87 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 21-26 12422375-6 2003 In DA-innervated striata, Prazosin significantly reduced the expression of Fos but only in the presence of serotonergic innervation. Prazosin 26-34 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 75-78