PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25914645-7	2015	SLC22A1 IC50 values for efavirenz, darunavir, and prazosin were determined.	Prazosin	50-58	solute carrier family 22 member 1	Homo sapiens	0-7	
25914645-11	2015	Absolute SLC22A1 IC50 values for efavirenz, darunavir, and prazosin were 21.8, 46.2, and 2.8 muM, respectively.	Prazosin	59-67	solute carrier family 22 member 1	Homo sapiens	9-16	
25914645-12	2015	Efavirenz accumulation was higher in SLC22A1-expressing cells compared to mock-transfected cells (17% higher, p = 0.009) which was reversed using prazosin, whereas no difference was observed for darunavir (p = 0.86).	Prazosin	146-154	solute carrier family 22 member 1	Homo sapiens	37-44	
12110607-11	2002	Progesterone and beta-Oestradiol preferentially inhibited hOCT3 and hOCT1, whereas prazosin was a potent inhibitor of hOCT1 and hOCT3.	Prazosin	83-91	solute carrier family 22 member 1	Homo sapiens	118-123	
22913740-5	2014	Known inhibitors of hOCT1 and hOCT2 activities such as verapamil, amitriptyline, prazosin, and quinine were next demonstrated to decrease rhodamine 123 accumulation in hOCT1- and hOCT2-overexpressing HEK293 cells.	Prazosin	81-89	solute carrier family 22 member 1	Homo sapiens	20-25	
22913740-5	2014	Known inhibitors of hOCT1 and hOCT2 activities such as verapamil, amitriptyline, prazosin, and quinine were next demonstrated to decrease rhodamine 123 accumulation in hOCT1- and hOCT2-overexpressing HEK293 cells.	Prazosin	81-89	solute carrier family 22 member 1	Homo sapiens	168-173	
21605667-8	2011	Co-incubation with the OCT1 inhibitor prazosin (3 muM) and the OCT3 inhibitor corticosterone (1 muM) resulted in a significant (p<0.01) decrease to 72% and 85% of the accumulation in control conditions, respectively.	Prazosin	38-46	solute carrier family 22 member 1	Homo sapiens	23-27	
16597591-5	2006	The addition of prazosin, a potent inhibitor of OCT-1 cellular transporter, reduced the IUR and eliminated interpatient variability.	Prazosin	16-24	solute carrier family 22 member 1	Homo sapiens	48-53	
21886172-1	2012	Imatinib is a substrate for hOCT1 (SLC22A1) and inhibitors of this influx transporter, such as amantadine and prazosin, have previously been shown to decrease cellular imatinib uptake.	Prazosin	110-118	solute carrier family 22 member 1	Homo sapiens	28-33	
21886172-1	2012	Imatinib is a substrate for hOCT1 (SLC22A1) and inhibitors of this influx transporter, such as amantadine and prazosin, have previously been shown to decrease cellular imatinib uptake.	Prazosin	110-118	solute carrier family 22 member 1	Homo sapiens	35-42	
12110607-16	2002	These compounds enable a functional discrimination of the three hOCTs: hOCT1 is selectively inhibited by prazosin, reversibly inhibited by PbA and it is not sensitive to inhibition by SKF550 and OMI; hOCT2 is reversibly inhibited by SKF550, irreversibly by PbA and not by prazosin, beta-oestradiol and OMI, whereas hOCT3 is selectively inhibited by corticosterone, OMI and decynium22.	Prazosin	272-280	solute carrier family 22 member 1	Homo sapiens	71-76	
12110607-16	2002	These compounds enable a functional discrimination of the three hOCTs: hOCT1 is selectively inhibited by prazosin, reversibly inhibited by PbA and it is not sensitive to inhibition by SKF550 and OMI; hOCT2 is reversibly inhibited by SKF550, irreversibly by PbA and not by prazosin, beta-oestradiol and OMI, whereas hOCT3 is selectively inhibited by corticosterone, OMI and decynium22.	Prazosin	105-113	solute carrier family 22 member 1	Homo sapiens	71-76	
34238184-12	2022	RESULTS: The results showed that amantadine (an OCT1/2 inhibitor) and prazosin (an OCT1/3 inhibitor) significantly decreased the cellular accumulation of fluoxetine (P <.001).	Prazosin	70-78	solute carrier family 22 member 1	Homo sapiens	83-89