PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19700947-3	2009	Prazosin, a nonsedating generic medication used for hypertension and benign prostatic hypertrophy, antagonizes NE effects at brain postsynaptic alpha-1 adrenoreceptors.	Prazosin	0-8	BCL2 related protein A1	Homo sapiens	144-151	
33398294-3	2021	Having an active prescription for an alpha 1 -AR antagonist (tamsulosin, silodosin, prazosin, terazosin, doxazosin, or alfuzosin) at the time of admission had a significant negative association with in-hospital mortality (relative risk reduction 14%; odds ratio 0.75; 95% CI 0.66 to 0.86; p <= 0.001).	Prazosin	84-92	BCL2 related protein A1	Homo sapiens	37-44	
33012871-4	2020	This has led to the theory that alleviation of drug dreams and suppression of involved neurocircuits may potentially reduce subsequent craving and relapse in the treatment of substance use disorders, with an important potential agent being the alpha-1 antagonist, prazosin.	Prazosin	264-272	BCL2 related protein A1	Homo sapiens	244-251	
32449942-3	2020	Significant preclinical evidence suggests that noradrenergic disruption may contribute to these alcohol-related stress arousal changes and that alpha-1 adrenergic antagonists, such as prazosin, may normalize these stress system adaptations and reduce alcohol intake.	Prazosin	184-192	BCL2 related protein A1	Homo sapiens	144-151	
34949210-2	2021	Prazosin, an alpha-1 receptor antagonist, has been used in patients with posttraumatic stress disorder to mitigate the increased alpha-1 activity involved in fear and startle responses.	Prazosin	0-8	BCL2 related protein A1	Homo sapiens	13-20	
34949210-2	2021	Prazosin, an alpha-1 receptor antagonist, has been used in patients with posttraumatic stress disorder to mitigate the increased alpha-1 activity involved in fear and startle responses.	Prazosin	0-8	BCL2 related protein A1	Homo sapiens	129-136	
34949210-13	2021	Prazosin may provide clinical improvement in patients with Neurobeachin gene deletions due to its theoretical attenuation in fear response through alpha-1 antagonism.	Prazosin	0-8	BCL2 related protein A1	Homo sapiens	147-154	
34168279-5	2021	In contrast, prazosin inhibition of alpha-1 NERs systemically reduced both CLAD and AOD.	Prazosin	13-21	BCL2 related protein A1	Homo sapiens	36-43