PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6323192-0	1984	Yohimbine induces sympathetically mediated renin release in the conscious rat.	Yohimbine	0-9	renin	Rattus norvegicus	43-48	
3285225-0	1988	The mechanism of yohimbine-induced renin release in the conscious rat.	Yohimbine	17-26	renin	Rattus norvegicus	35-40	
3285225-1	1988	These studies were designed to determine the role of the central nervous system, the sympathetic nervous system, the adrenal glands and the renal sympathetic nerves in yohimbine-induced renin release in conscious rats.	Yohimbine	168-177	renin	Rattus norvegicus	186-191	
3285225-2	1988	Yohimbine (0.3-10 mg/kg, s.c.) caused time- and dose-related increases in plasma renin activity (PRA) and concentration (PRC) which were accompanied by time- and dose-related elevations of plasma norepinephrine (NE) and epinephrine (Epi) concentrations.	Yohimbine	0-9	renin	Rattus norvegicus	81-86	
3285225-6	1988	An increase in circulating plasma catecholamine concentrations appeared to mediate yohimbine-induced renin release since propranolol prevented the rise in PRA caused by yohimbine in renal denervated rats.	Yohimbine	83-92	renin	Rattus norvegicus	101-106	
3285225-11	1988	Based on these results, we conclude that 1) the stimulation of renin release by yohimbine is a secondary neurohormonal consequence of the generalized increase in sympathetic activity caused by yohimbine, 2) the sympathoadrenal activation produced by yohimbine results from an action in the brain which is amplified by the simultaneous blockade of prejunctional alpha 2-adrenoceptors.	Yohimbine	80-89	renin	Rattus norvegicus	63-68	
3285225-11	1988	Based on these results, we conclude that 1) the stimulation of renin release by yohimbine is a secondary neurohormonal consequence of the generalized increase in sympathetic activity caused by yohimbine, 2) the sympathoadrenal activation produced by yohimbine results from an action in the brain which is amplified by the simultaneous blockade of prejunctional alpha 2-adrenoceptors.	Yohimbine	193-202	renin	Rattus norvegicus	63-68	
3285225-11	1988	Based on these results, we conclude that 1) the stimulation of renin release by yohimbine is a secondary neurohormonal consequence of the generalized increase in sympathetic activity caused by yohimbine, 2) the sympathoadrenal activation produced by yohimbine results from an action in the brain which is amplified by the simultaneous blockade of prejunctional alpha 2-adrenoceptors.	Yohimbine	193-202	renin	Rattus norvegicus	63-68	
6323192-1	1984	The preferential alpha 2-adrenergic antagonist yohimbine (4 mg/kg s.c.) caused a time-related increase in serum renin activity and heart rate in conscious Sprague-Dawley rats.	Yohimbine	47-56	renin	Rattus norvegicus	112-117	
6323192-4	1984	Yohimbine (0.3, 1, 3 and 10 mg/kg s.c.) elicited a dose-related increase in serum renin activity and heart rate (30 min post-injection).	Yohimbine	0-9	renin	Rattus norvegicus	82-87	
6323192-7	1984	The beta-adrenergic receptor antagonist propranolol (1.5 mg/kg s.c.), blocked the renin release and tachycardia caused by yohimbine (1 and 3 mg/kg s.c.), and the ganglionic blocking agent chlorisondamine partially inhibited the renin release elicited by 3 mg/kg (s.c.) of yohimbine.	Yohimbine	122-131	renin	Rattus norvegicus	82-87	
6323192-9	1984	Thus, the increase in renin release caused by yohimbine appears to be mediated by the sympathetic nervous system.	Yohimbine	46-55	renin	Rattus norvegicus	22-27	
6323192-10	1984	Because the smaller doses of yohimbine increase renin release in the absence of a decrease in mean arterial pressure, it is unlikely that yohimbine stimulates renin release by baroreflex-mediated activation of the renal sympathetic nerves.	Yohimbine	29-38	renin	Rattus norvegicus	48-53	
8156394-7	1994	Although yohimbine alone increased plasma renin activity and concentration, it did not prevent the suppressive effects of fenfluramine.	Yohimbine	9-18	renin	Rattus norvegicus	42-47