PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3884090-1 1985 Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate. Ketoglutaric Acids 176-195 pyruvate carboxylase Homo sapiens 0-20 10736368-2 2000 This is because glutamate is in isotopic equilibrium with alpha-ketoglutarate, whose labeling pattern is influenced by the following: 1) the contributions of glucose and fatty acids to acetyl-CoA, 2) the relative contributions of pyruvate carboxylase and pyruvate dehydrogenase to the entry of pyruvate carbon into the citric acid cycle, and 3) the rate of gluconeogenesis in relation to citric acid cycle activity. Ketoglutaric Acids 58-77 pyruvate carboxylase Homo sapiens 230-250