PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28123531-0	2017	Goniothalamin induces mitochondria-mediated apoptosis associated with endoplasmic reticulum stress-induced activation of JNK in HeLa cells.	goniothalamin	0-13	mitogen-activated protein kinase 8	Homo sapiens	121-124	
28123531-4	2017	The present study focused on elucidation of the mitochondria-mediated apoptosis associated with endoplasmic reticulum (ER) stress-induced activation of c-Jun NH2-terminal kinase (JNK) by goniothalamin in HeLa cervical cancer cells.	goniothalamin	187-200	mitogen-activated protein kinase 8	Homo sapiens	152-177	
28123531-4	2017	The present study focused on elucidation of the mitochondria-mediated apoptosis associated with endoplasmic reticulum (ER) stress-induced activation of c-Jun NH2-terminal kinase (JNK) by goniothalamin in HeLa cervical cancer cells.	goniothalamin	187-200	mitogen-activated protein kinase 8	Homo sapiens	179-182	
28123531-12	2017	In addition, the levels of phosphorylated JNK and the transcription factor, C/EBP homologous protein (CHOP), an ER stress-associated apoptotic molecule, were increased in the goniothalamin-treated cells.	goniothalamin	175-188	mitogen-activated protein kinase 8	Homo sapiens	42-45	
28123531-13	2017	These data indicated that goniothalamin exerted a cytotoxic effect against HeLa cells via the induction of mitochondria-mediated apoptosis, associated with ER stress-induced activation of JNK.	goniothalamin	26-39	mitogen-activated protein kinase 8	Homo sapiens	188-191	
27016270-7	2016	In HT-29 cells, treatment with 10muM of GTN induced apoptosis by increasing BAX/BCL2, p-JNK1/JNK1, p-P38/P38 ratios as well as through ROS generation.	goniothalamin	40-43	mitogen-activated protein kinase 8	Homo sapiens	88-92	
27016270-7	2016	In HT-29 cells, treatment with 10muM of GTN induced apoptosis by increasing BAX/BCL2, p-JNK1/JNK1, p-P38/P38 ratios as well as through ROS generation.	goniothalamin	40-43	mitogen-activated protein kinase 8	Homo sapiens	93-97	
26987063-5	2016	In addition, goniothalamin induced apoptosis via p-JNK1/2 and p-p38 upregulation and inhibited cell survival via p-ERK1/2 and p-Akt downregulation.	goniothalamin	13-26	mitogen-activated protein kinase 8	Homo sapiens	51-57	
26987063-8	2016	Therefore, goniothalamin promoted apoptosis associated with autophagy induction in SK-BR-3 cells through p-p38 and p-JNK1/2 upregulation and p-Akt downregulation.	goniothalamin	11-24	mitogen-activated protein kinase 8	Homo sapiens	117-121