PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30796460-5	2019	Moreover, Cd treatment also activated three branches (ATF6, PERK and IRE-1alpha) of endoplasmic reticulum stress.	Cadmium	10-12	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	69-79	
30796460-6	2019	Selective inhibition of the IRE-1alpha/XBP-1s branch by a pharmacological inhibitor STF-083010 or by genetic silencing of XBP-1 significantly attenuated Cd-induced NLRP3 inflammasome activation and pyroptosis.	Cadmium	153-155	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	28-38	
29444456-7	2018	Activation of AKT by SC79 or inhibition of GJIC by 18alpha-glycyrrhetinic acid (18alpha-GA) completely abolished Cd-induced AKT inhibition and IRE1alpha-ASK1 activation.	Cadmium	113-115	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	143-152	
30796460-8	2019	Activation of SIRT1 using a pharmacological agonist resveratrol or genetic SIRT1 overexpression significantly abolished Cd-induced activation of the IRE-1alpha/XBP-1s pathway and the NRLP3 inflammasome as well as pyroptosis, which were counteracted by co-overexpression of both SIRT1 and XBP-1s.	Cadmium	120-122	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	149-159	
33813002-0	2021	Dual role of inositol-requiring enzyme 1alpha (IRE-1alpha) in Cd-induced apoptosis in human renal tubular epithelial cells: endoplasmic reticulum stress and STAT3 signaling activation.	Cadmium	62-64	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	47-57	
33813002-4	2021	This study aimed to investigate whether the two enzymatic activities of IRE-1alpha have different effects in its regulation of Cd-induced apoptosis.	Cadmium	127-129	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	72-82	
33813002-8	2021	Interestingly, inhibition of IRE-1alpha kinase activity by KIRA6 was more protective against Cd-induced apoptosis than inhibition of its RNase activity by STF-083010.	Cadmium	93-95	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	29-39	
33813002-9	2021	Mechanistically, Cd promoted the binding of IRE-1alpha with signal transducer and activator of transcription-3 (STAT3) leading to elevated phosphorylation of STAT3 at Ser727 and thus inactivation of STAT3 signaling, which resulted in aggravation of Cd-induced apoptosis in HK-2 cells.	Cadmium	17-19	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	44-54	
33813002-9	2021	Mechanistically, Cd promoted the binding of IRE-1alpha with signal transducer and activator of transcription-3 (STAT3) leading to elevated phosphorylation of STAT3 at Ser727 and thus inactivation of STAT3 signaling, which resulted in aggravation of Cd-induced apoptosis in HK-2 cells.	Cadmium	249-251	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	44-54	
33813002-10	2021	Collectively, our findings indicate that IRE-1alpha coordinate ER stress and STAT3 signaling in mediating Cd-induced renal toxicity, suggesting that targeting IRE-1alpha might be a potential therapeutic approach for Cd-induced renal dysfunction and disease.	Cadmium	106-108	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	41-51	
33813002-10	2021	Collectively, our findings indicate that IRE-1alpha coordinate ER stress and STAT3 signaling in mediating Cd-induced renal toxicity, suggesting that targeting IRE-1alpha might be a potential therapeutic approach for Cd-induced renal dysfunction and disease.	Cadmium	106-108	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	159-169	
33813002-10	2021	Collectively, our findings indicate that IRE-1alpha coordinate ER stress and STAT3 signaling in mediating Cd-induced renal toxicity, suggesting that targeting IRE-1alpha might be a potential therapeutic approach for Cd-induced renal dysfunction and disease.	Cadmium	216-218	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	41-51	
33813002-10	2021	Collectively, our findings indicate that IRE-1alpha coordinate ER stress and STAT3 signaling in mediating Cd-induced renal toxicity, suggesting that targeting IRE-1alpha might be a potential therapeutic approach for Cd-induced renal dysfunction and disease.	Cadmium	216-218	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	159-169