PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23698114-3 2013 Because aldosterone and endothelin-1 (ET-1) have opposing actions on Na reabsorption (JNa) in the kidney, we postulated that stimulation of ET-1 by aldosterone acts as a negative feedback mechanism, acting locally within the CD. Cadmium 225-227 endothelin 1 Mus musculus 24-36 26400543-2 2015 Aldosterone also stimulates endothelin-1 (ET-1) production that acts within the CD to inhibit Na reabsorption via a negative feedback mechanism. Cadmium 80-82 endothelin 1 Mus musculus 28-40 26400543-2 2015 Aldosterone also stimulates endothelin-1 (ET-1) production that acts within the CD to inhibit Na reabsorption via a negative feedback mechanism. Cadmium 80-82 endothelin 1 Mus musculus 42-46 26400543-3 2015 We tested the hypothesis that this renal aldosterone-endothelin feedback system regulates electrolyte balance and BP by comparing the effect of a high-salt (NaCl) diet and mineralocorticoid stimulation in control and CD-specific ET-1 knockout (CD ET-1 KO) mice. Cadmium 217-219 endothelin 1 Mus musculus 229-233 26400543-9 2015 We conclude that local ET-1 production in the CD is required for the appropriate renal response to Na loading and that lack of local ET-1 results in abnormal fluid and electrolyte handling when challenged with a high-salt diet and with DOCP treatment. Cadmium 46-48 endothelin 1 Mus musculus 23-27 25391901-4 2015 Given that ET-1 stimulates NO production in the CD, we hypothesized that shear stress-induced NO production is downstream of shear stress-induced ENaC activation and ET-1 production in a negative feedback loop. Cadmium 48-50 endothelin 1 Mus musculus 11-15 25391901-4 2015 Given that ET-1 stimulates NO production in the CD, we hypothesized that shear stress-induced NO production is downstream of shear stress-induced ENaC activation and ET-1 production in a negative feedback loop. Cadmium 48-50 endothelin 1 Mus musculus 166-170 23698114-3 2013 Because aldosterone and endothelin-1 (ET-1) have opposing actions on Na reabsorption (JNa) in the kidney, we postulated that stimulation of ET-1 by aldosterone acts as a negative feedback mechanism, acting locally within the CD. Cadmium 225-227 endothelin 1 Mus musculus 140-144 23698114-5 2013 In contrast, ET-1 increases Na and water excretion through its binding to receptors in the CD. Cadmium 91-93 endothelin 1 Mus musculus 13-17 23698114-6 2013 To date, direct measurement of the quantitative effect of ET-1 on transepithelial JNa in the isolated in vitro microperfused mouse CD has not been determined. Cadmium 131-133 endothelin 1 Mus musculus 58-62 22209709-3 2012 Dexamethasone (1muM) induced a 4-fold increase in Edn1 mRNA in mIMCD-3 inner medullary CD cells. Cadmium 66-68 endothelin 1 Mus musculus 50-54 21918182-2 2012 Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure. Cadmium 53-55 endothelin 1 Mus musculus 14-18 21918182-6 2012 ET-1 significantly decreased ENaC open probability in CD isolated from wild-type (WT) and CD ETA KO mice but not CD ETB KO and CD ETA/B KO mice. Cadmium 54-56 endothelin 1 Mus musculus 0-4 21918182-6 2012 ET-1 significantly decreased ENaC open probability in CD isolated from wild-type (WT) and CD ETA KO mice but not CD ETB KO and CD ETA/B KO mice. Cadmium 90-92 endothelin 1 Mus musculus 0-4 21918182-6 2012 ET-1 significantly decreased ENaC open probability in CD isolated from wild-type (WT) and CD ETA KO mice but not CD ETB KO and CD ETA/B KO mice. Cadmium 90-92 endothelin 1 Mus musculus 0-4 15314687-1 2004 In vitro studies suggest that collecting duct-derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown. Cadmium 55-57 endothelin 1 Mus musculus 67-79 21893992-2 2011 ET-1 has the potential to act as an autocrine regulator of CD function since ET-1 is secreted abluminally and ET receptors are located primarily on the basolateral side of the CD cell. Cadmium 59-61 endothelin 1 Mus musculus 0-4 21893992-2 2011 ET-1 has the potential to act as an autocrine regulator of CD function since ET-1 is secreted abluminally and ET receptors are located primarily on the basolateral side of the CD cell. Cadmium 59-61 endothelin 1 Mus musculus 77-81 21893992-2 2011 ET-1 has the potential to act as an autocrine regulator of CD function since ET-1 is secreted abluminally and ET receptors are located primarily on the basolateral side of the CD cell. Cadmium 176-178 endothelin 1 Mus musculus 0-4 21893992-3 2011 A large number of in vitro studies have supported this notion of an autocrine function for ET-1, demonstrating that the peptide, largely through activation of the ET(B) receptor, inhibits both sodium (Na) and water reabsorption in the CD. Cadmium 235-237 endothelin 1 Mus musculus 91-95 21893992-4 2011 The physiologic relevance of these findings has been confirmed in vivo wherein mice with CD-specific knockout of ET-1 are hypertensive on a normal Na diet and develop worsened hypertension associated with Na retention when placed on a high-Na diet. Cadmium 89-91 endothelin 1 Mus musculus 113-117 21893992-10 2011 ET-1 reduces CD water reabsorption by inhibition of vasopressin-stimulated adenylyl cyclase activity through G(i) and protein kinase C-dependent pathways, leading to a reduction in cellular cAMP levels. Cadmium 13-15 endothelin 1 Mus musculus 0-4 15928212-1 2005 Collecting duct (CD)-specific knockout (KO) of endothelin-1 (ET-1) causes hypertension, impaired ability to excrete a Na load, and enhanced CD sensitivity to the hydrosmotic effects of vasopressin (AVP). Cadmium 17-19 endothelin 1 Mus musculus 47-59 15928212-1 2005 Collecting duct (CD)-specific knockout (KO) of endothelin-1 (ET-1) causes hypertension, impaired ability to excrete a Na load, and enhanced CD sensitivity to the hydrosmotic effects of vasopressin (AVP). Cadmium 17-19 endothelin 1 Mus musculus 61-65 15632412-6 2005 CD suspensions from CD ET-1 KO mice had enhanced AVP- and forskolin-stimulated cAMP accumulation. Cadmium 0-2 endothelin 1 Mus musculus 23-27 15632412-7 2005 These data indicate that CD ET-1 KO increases renal sensitivity to the urinary concentrating effects of AVP and suggest that ET-1 functions as a physiological autocrine regulator of AVP action in the CD. Cadmium 25-27 endothelin 1 Mus musculus 28-32 15314687-1 2004 In vitro studies suggest that collecting duct-derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown. Cadmium 55-57 endothelin 1 Mus musculus 81-85 15314687-1 2004 In vitro studies suggest that collecting duct-derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown. Cadmium 156-158 endothelin 1 Mus musculus 167-171 15314687-8 2004 These studies indicate that CD-derived ET-1 is an important physiologic regulator of renal Na excretion and systemic BP. Cadmium 28-30 endothelin 1 Mus musculus 39-43