PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16600084-0 2006 [The effects of cadmium on the levels of insulin in smelters]. Cadmium 16-23 insulin Homo sapiens 41-48 17488788-10 2007 In both groups a positive correlation between 2-h insulin and AMH concentrations was observed (PCOSd: r = 0.530, P = 0.007; Cd: r =0.561, P = 0.008). Cadmium 124-126 insulin Homo sapiens 50-57 16600084-11 2006 CONCLUSION: The exposure to cadmium can cause the decrease of serum insulin and may affect the level of blood glucose. Cadmium 28-35 insulin Homo sapiens 68-75 16246845-3 2005 In this study we investigated the fibrillation of monomeric human insulin by monitoring changes in CD, attenuated total reflectance-Fourier transform infrared spectroscopy, 8-anilinonaphthalenesulfonic acid fluorescence, thioflavin T fluorescence, dynamic light scattering, and H/D exchange during the initial stages of the fibrillation process to provide insight into early events involving the monomer. Cadmium 99-101 insulin Homo sapiens 66-73 16289538-6 2006 The changes in protein structure was not only related to the adsorbed species being monomeric, since CD and fluorescence results were different for adsorbed insulin compared to a monomeric analog of human insulin. Cadmium 101-103 insulin Homo sapiens 157-164 16600084-1 2006 OBJECTIVE: To investigate the effects of cadmium on the levels of insulin and blood glucose in exposed workers. Cadmium 41-48 insulin Homo sapiens 66-73 16600084-4 2006 The variety of the level of serum insulin was investigated for the workers in different groups of the exposure time, the blood cadmium and the urine cadmium. Cadmium 127-134 insulin Homo sapiens 34-41 16600084-4 2006 The variety of the level of serum insulin was investigated for the workers in different groups of the exposure time, the blood cadmium and the urine cadmium. Cadmium 149-156 insulin Homo sapiens 34-41 16600084-8 2006 The level of serum insulin in the group of the exposure time of more than 10 years [(8.58 +/- 4.91) microIU/ml] was significantly lower than that in the control group [(11.57 +/- 5.42) microIU] with the significantly statistical difference (P < 0.05) and the level of serum insulin would be decreased significantly with the increase of the blood cadmium and urinary cadmium. Cadmium 349-356 insulin Homo sapiens 19-26 16600084-8 2006 The level of serum insulin in the group of the exposure time of more than 10 years [(8.58 +/- 4.91) microIU/ml] was significantly lower than that in the control group [(11.57 +/- 5.42) microIU] with the significantly statistical difference (P < 0.05) and the level of serum insulin would be decreased significantly with the increase of the blood cadmium and urinary cadmium. Cadmium 369-376 insulin Homo sapiens 19-26 16600084-10 2006 The correlation analysis indicated that the negative correlation was found between the level of serum insulin and the level of blood cadmium, as well as between the level of the serum insulin and the level of the urinary cadmium; the positive correlation was found between the level of blood glucose and the level of insulin, as well as between the level of blood glucose and the level of C peptide in serum. Cadmium 133-140 insulin Homo sapiens 102-109 16600084-10 2006 The correlation analysis indicated that the negative correlation was found between the level of serum insulin and the level of blood cadmium, as well as between the level of the serum insulin and the level of the urinary cadmium; the positive correlation was found between the level of blood glucose and the level of insulin, as well as between the level of blood glucose and the level of C peptide in serum. Cadmium 221-228 insulin Homo sapiens 184-191 16600084-10 2006 The correlation analysis indicated that the negative correlation was found between the level of serum insulin and the level of blood cadmium, as well as between the level of the serum insulin and the level of the urinary cadmium; the positive correlation was found between the level of blood glucose and the level of insulin, as well as between the level of blood glucose and the level of C peptide in serum. Cadmium 221-228 insulin Homo sapiens 184-191 12661070-7 2003 However, the shape and intensity of difference CD spectra, obtained by subtraction of the spectra measured in 20% acetic acid (where all insulin species were monomeric) from the corresponding spectra measured at neutral pH, correlate well with the degree of insulin association. Cadmium 47-49 insulin Homo sapiens 258-265 16139686-4 2005 Na,K-ATPase activity and expression in the CD are modulated physiologically by hormones (aldosterone, vasopressin, and insulin) and nonhormonal factors including intracellular [Na+] and extracellular osmolality. Cadmium 43-45 insulin Homo sapiens 119-126 15356868-6 2004 Amyloid films of Abeta-(1-40) peptide, beta-2-microglobulin, insulin, and three homopolypeptides show very intense CD spectra, compatible with the presence of a beta-helix-like structure, arranged in a common framework in the fibrils. Cadmium 115-117 insulin Homo sapiens 61-68 12661070-8 2003 In fact, the near-UV CD difference spectra for monomeric, dimeric, tetrameric, and hexameric insulin are very distinctive, both in terms of intensity and shape. Cadmium 21-23 insulin Homo sapiens 93-100 3126291-2 1988 A system approach to the analysis of pharmacodynamic systems is applied to the relationship between the glyburide serum concentration (Cd) and a resulting pharmacologic effect response, that is, the C-peptide serum concentration (Cc) in patients with non-insulin dependent diabetes mellitus (NIDDM). Cadmium 135-137 insulin Homo sapiens 199-208 11589968-2 2001 CD spectra indicate that D-glucose interacts with monomeric insulin whereas D-galactose, D-mannose and 2-deoxy-D-glucose have a lower effect. Cadmium 0-2 insulin Homo sapiens 60-67 10521251-3 1999 (1)H NMR, (113)Cd NMR, and UV-vis measurements demonstrate that, under suitable conditions, Fe2+/3+, Ni2+, and Cd2+ bind insulin to form stable hexamers, which are allosteric species. Cadmium 15-17 insulin Homo sapiens 121-128 7588523-2 1995 Using oxidized insulin chain B as a test peptide, we demonstrate the use of an Immobilon CD membrane to capture and preconcentrate peptides. Cadmium 89-91 insulin Homo sapiens 15-22 34536371-4 2022 Adverse health effects (bronchus and lung cancers for 15-65 years old people) were observed for hydrofluoric acid at low background concentration (<0.003 mug m-3) while exposure to particulate cadmium (0.210-0.250 mug m-3) disrupts insulin metabolism for people over 65 years-old leading to diabetes. Cadmium 193-200 insulin Homo sapiens 232-239 35550884-4 2022 It was shown that oral Cd exposure in drinking water followed by washout and high fat diet (HFD) in C57BL/6N mice results in islet Cd bioaccumulation comparable to that found in native human islets while mitigating the anorexic effects of Cd to achieve the same weight gain required to induce insulin resistance as in Cd naive control mice. Cadmium 23-25 insulin Homo sapiens 293-300 35550884-6 2022 Regression analysis showed an inverse correlation between islet Cd level and plasma insulin following a glucose challenge in males but not in females. Cadmium 64-66 insulin Homo sapiens 84-91 3533813-7 1986 Furthermore as occurred in the crystal, it was found that in solution the transformation was reversible (on removal of thiocyanate) and that 2 Cd insulin was unable to undergo the transformation. Cadmium 143-145 insulin Homo sapiens 146-153 3311071-3 1987 The CD-spectral changes are strikingly similar to those brought about by halide ions which have been identified to reflect the 2 Zn----4 Zn insulin transition. Cadmium 4-6 insulin Homo sapiens 140-147 34030321-0 2021 Adipose tissue cadmium concentrations as a potential risk factor for insulin resistance and future type 2 diabetes mellitus in GraMo adult cohort. Cadmium 15-22 insulin Homo sapiens 69-76 324023-0 1977 Pancreatic metallothionein: protection against cadmium-induced inhibition of insulin secretory activity. Cadmium 47-54 insulin Homo sapiens 77-84 10622-12 1976 The near UV CD curve for DPI differs from that for insulin and has an extremum at 266nm as well as a low negative value of [iota]. Cadmium 12-14 insulin Homo sapiens 51-58 986008-5 1976 Some other drugs have similar, but mostly smaller effects on the CD spectrum of insulin. Cadmium 65-67 insulin Homo sapiens 80-87 7024084-9 1981 According to the substantial deviations of the CD spectrum of [Leu B24]insulin, the introduction of the new side-chain forces conformational changes to occur not only in its immediate surrounding but also in the peptide chain. Cadmium 47-49 insulin Homo sapiens 71-78 7024084-12 1981 [Leu B25]insulin, on the other hand, does exhibit all CD spectral effects characteristic of the native hormone, though quantitatively somewhat reduced. Cadmium 54-56 insulin Homo sapiens 9-16 34030321-12 2021 Interestingly, smokers in the 2nd tertile (T2) of adipose tissue Cd levels showed increased log-transformed insulin resistance (beta T2 vs T1: 0.52; 95% CI: 0.07, 0.97), as well as higher log-transformed insulin levels (beta T2 vs T1: 0.52; 95% CI: 0.08, 0.95). Cadmium 65-67 insulin Homo sapiens 108-115 34030321-12 2021 Interestingly, smokers in the 2nd tertile (T2) of adipose tissue Cd levels showed increased log-transformed insulin resistance (beta T2 vs T1: 0.52; 95% CI: 0.07, 0.97), as well as higher log-transformed insulin levels (beta T2 vs T1: 0.52; 95% CI: 0.08, 0.95). Cadmium 65-67 insulin Homo sapiens 204-211 32599884-14 2020 Available data suggest Cd exposure is associated with an increased propensity to increased insulin resistance. Cadmium 23-25 insulin Homo sapiens 91-98 33977204-6 2021 Despite no changes in body composition, CD-fed Rptor ob -/- mice exhibited significant lower fasting insulin and glucose levels and increased insulin sensitivity. Cadmium 40-42 insulin Homo sapiens 101-108 33977204-6 2021 Despite no changes in body composition, CD-fed Rptor ob -/- mice exhibited significant lower fasting insulin and glucose levels and increased insulin sensitivity. Cadmium 40-42 insulin Homo sapiens 142-149 33630217-9 2022 Compared with individuals in the lowest quartile, those in the highest quartile of toenail Cd had a significantly higher odds of NAFLD (OR: 1.43, 95% CI: 1.02, 1.99, P for trend: 0.04) after adjustment for demographics, socioeconomics, major lifestyle factors, and baseline levels of body mass index, lipids, and fasting insulin. Cadmium 91-93 insulin Homo sapiens 321-328 33396420-7 2020 Islets from 12 week Cd-treated animals had significantly less glucose-stimulated insulin release compared to islets from saline-treated control animals. Cadmium 20-22 insulin Homo sapiens 81-88 33259630-0 2020 Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring. Cadmium 12-14 insulin Homo sapiens 71-78 33259630-6 2020 Results of glucose and insulin tolerance testing revealed that Cd exposure impaired offspring glucose homeostasis on PND42. Cadmium 63-65 insulin Homo sapiens 23-30 32867022-0 2020 Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data. Cadmium 23-30 insulin Homo sapiens 44-51 32867022-4 2020 Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to beta-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. Cadmium 0-2 insulin Homo sapiens 192-199 32867022-4 2020 Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to beta-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. Cadmium 0-2 insulin Homo sapiens 215-222 32867022-5 2020 This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Cadmium 59-61 insulin Homo sapiens 74-81 32867022-6 2020 Available data have shown that Cd may affect normal insulin function through multiple pathways. Cadmium 31-33 insulin Homo sapiens 52-59 32867022-7 2020 There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cadmium 23-25 insulin Homo sapiens 114-121 32867022-8 2020 Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in beta-cells. Cadmium 0-2 insulin Homo sapiens 114-121 32867022-9 2020 More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance. Cadmium 67-69 insulin Homo sapiens 79-86 31270625-0 2019 Electrochemiluminescent immunoassay for insulin by using a quencher pair consisting of CdS:Eu nanoclusters loaded with multiwalled carbon nanotubes on reduced graphene oxide nanoribbons and gold nanoparticle-loaded octahedral Cu2O. Cadmium 87-90 insulin Homo sapiens 40-47 31686724-12 2019 In turn, laboratory studies demonstrated that Cd adversely affects adipose tissue physiopathology through several mechanisms, thus contributing to increased insulin resistance and enhancing diabetes. Cadmium 46-48 insulin Homo sapiens 157-164 30573355-7 2019 In contrast, postprandial insulin incremental area (iAUC0-5h) was 31% lower (p < 0.05), insulin secretion index was 18% lower (p < 0.016) and insulin sensitivity (SI) index was 36% higher (p = 0.037) after the RGPD compared to CD. Cadmium 227-229 insulin Homo sapiens 26-33 31109605-1 2019 PURPOSE: Previous studies have suggested a role for the toxic elements lead (Pb), mercury (Hg) and cadmium (Cd) in the development of insulin resistance and hypertension. Cadmium 99-106 insulin Homo sapiens 134-141 31109605-1 2019 PURPOSE: Previous studies have suggested a role for the toxic elements lead (Pb), mercury (Hg) and cadmium (Cd) in the development of insulin resistance and hypertension. Cadmium 108-110 insulin Homo sapiens 134-141 28525853-0 2017 Photoelectrochemical sensitive detection of insulin based on CdS/polydopamine co-sensitized WO3 nanorod and signal amplification of carbon nanotubes@polydopamine. Cadmium 61-64 insulin Homo sapiens 44-51 28577409-7 2017 In turn, laboratory studies demonstrated that cadmium adversely affects adipose tissue physiopathology through several mechanisms, thus contributing to increased insulin resistance and enhancing diabetes. Cadmium 46-53 insulin Homo sapiens 162-169 28525853-1 2017 An ultrasensitive photoelectrochemical sandwich immunosensor was designed for detection of insulin based on WO3/CdS/polydopamine (WO3/CdS/PDA) co-sensitized and PDA@carbon nanotubes (PDA@CNT) conjugates for signal amplification. Cadmium 112-115 insulin Homo sapiens 91-98 28525853-1 2017 An ultrasensitive photoelectrochemical sandwich immunosensor was designed for detection of insulin based on WO3/CdS/polydopamine (WO3/CdS/PDA) co-sensitized and PDA@carbon nanotubes (PDA@CNT) conjugates for signal amplification. Cadmium 134-137 insulin Homo sapiens 91-98 28643554-10 2017 In regression analyses, plasma insulin and glucose concentrations were positively correlated to CD, particularly after BR ( r=0.31, p<0.05). Cadmium 96-98 insulin Homo sapiens 31-38 27387260-0 2016 Visible-light driven photoelectrochemical immunosensor for insulin detection based on MWCNTs@SnS2@CdS nanocomposites. Cadmium 98-101 insulin Homo sapiens 59-66 29379585-8 2017 This study indicates that cadmium burden alters glycemic control in adolescents and suggests that oxidative stress plays a key role in cadmium-induced insulin resistance, increasing the risk of developing metabolic disorders. Cadmium 135-142 insulin Homo sapiens 151-158 27387260-1 2016 In this work, a label-free photoelectrochemical (PEC) immunosensor was developed for ultrasensitive detection of insulin based on MWCNTs@SnS2@CdS nanocomposites. Cadmium 142-145 insulin Homo sapiens 113-120 27387260-5 2016 The as constructed label-free PEC immunosensor based on MWCNTs@SnS2@CdS nanocomposites exhibited excellent PEC performance for the detection of insulin. Cadmium 68-71 insulin Homo sapiens 144-151 27387260-9 2016 The design and fabrication of this PEC immunosensor based on MWCNTs@SnS2@CdS nanocomposites not only provided an ideal platform for the detection of insulin, but also opened up a new avenue for the development of immunosensor for some other biomarkers analysis. Cadmium 73-76 insulin Homo sapiens 149-156 26264451-3 2016 Both epidemiological and experimental studies show that exposure to the environmental pollutant cadmium (Cd), is associated with hyperglycemia, T2DM and reduced serum insulin. Cadmium 96-103 insulin Homo sapiens 167-174 26264451-3 2016 Both epidemiological and experimental studies show that exposure to the environmental pollutant cadmium (Cd), is associated with hyperglycemia, T2DM and reduced serum insulin. Cadmium 105-107 insulin Homo sapiens 167-174 19327375-6 2009 These studies also show that Cd reduces insulin levels and has direct cytotoxic effects on the pancreas. Cadmium 29-31 insulin Homo sapiens 40-47 23261793-0 2013 Cadmium exposure in relation to insulin production, insulin sensitivity and type 2 diabetes: a cross-sectional and prospective study in women. Cadmium 0-7 insulin Homo sapiens 32-39 23261793-0 2013 Cadmium exposure in relation to insulin production, insulin sensitivity and type 2 diabetes: a cross-sectional and prospective study in women. Cadmium 0-7 insulin Homo sapiens 52-59 23261793-12 2013 CONCLUSIONS: This is the first study of cadmium and diabetes with detailed data on pancreatic beta-cell function, insulin sensitivity and glucose tolerance. Cadmium 40-47 insulin Homo sapiens 114-121 22344736-9 2012 Daughters of women with PCOS having AMH concentrations greater than 2 standard deviation (SD) above the mean AMH value for the Cd group showed decreased serum follicle-stimulating hormone (FSH) concentrations and increased stimulated levels of insulin during Tanner stages I, II, and III. Cadmium 127-129 insulin Homo sapiens 244-251 21943314-0 2011 Reduced cytotoxicity of insulin-immobilized CdS quantum dots using PEG as a spacer. Cadmium 44-47 insulin Homo sapiens 24-31 20134158-10 2010 CD-fed SHR feature leptin and insulin resistance, hypertension and obesity, thus mimicking the situation of MS patients. Cadmium 0-2 insulin Homo sapiens 30-37 19340886-5 2009 The FTIR spectra of insulin in solution showed an increase in alpha-helix upon phenol binding and correlated well with the transition measured by CD yielding similar dissociation constants. Cadmium 146-148 insulin Homo sapiens 20-27