PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17327699-2 2007 Cadmium increased levels of expression of 27 genes, including genes for Mt1, Mt2, GSTa3 and B2m and reduced those of 4 genes. Cadmium 0-7 metallothionein 1 Rattus norvegicus 72-75 19938953-0 2009 Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injection. Cadmium 78-85 metallothionein 1 Rattus norvegicus 14-31 19938953-0 2009 Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injection. Cadmium 78-85 metallothionein 1 Rattus norvegicus 33-37 32059372-5 2020 At the molecular level, Cd induced an increase of MT-1 expression and caused an upregulation of ZIP2 accompanied with a down-regulation of ZnT5. Cadmium 24-26 metallothionein 1 Rattus norvegicus 50-54 32879253-10 2020 Cd is induced to synthesize and bind to metallothionein (MT-I and -II) and accumulate in the intestinal tissues, mainly in the duodenum. Cadmium 0-2 metallothionein 1 Rattus norvegicus 57-69 22127542-13 2012 Mt1a expression was clearly induced by cadmium but slightly reduced by E(2) compared to controls. Cadmium 39-46 metallothionein 1 Rattus norvegicus 0-4 20096345-2 2010 Cd induced histopathological changes in testicular tissues were accompanied by decreased plasma testosterone level, plasma and testicular Zn concentrations, oxidative stress, and by increased MT-1 and MT-2 gene expression. Cadmium 0-2 metallothionein 1 Rattus norvegicus 192-205 19938953-10 2009 The densitometry data shows that the expression of MT-1 mRNA increases with Cd treatment in testes. Cadmium 76-78 metallothionein 1 Rattus norvegicus 51-55 19938953-12 2009 However, upon Cd injection, the level of testes MT-1 mRNA increases 2.16 fold. Cadmium 14-16 metallothionein 1 Rattus norvegicus 48-52 19096765-4 2009 Compared to the (Pb + Cd) group with the lead or cadmium group, the expression level of MT-1 and MT-2 gene increased significantly (P < 0.01). Cadmium 49-56 metallothionein 1 Rattus norvegicus 88-101 17948763-10 2007 The expression of MT-I was higher in the groups exposed to 1.0 and 2.0 mg/kg x bw cadmium while the expression of MT-II was higher in the group exposed to 2.0 mg/kg x bw cadmium. Cadmium 82-89 metallothionein 1 Rattus norvegicus 18-22 17948763-11 2007 CONCLUSIONS: Cadmium may be accumulated in the pancreas, resulting in the change of the expression of insulin, MT-I and MT-II genes. Cadmium 13-20 metallothionein 1 Rattus norvegicus 111-115 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 72-74 metallothionein 1 Rattus norvegicus 20-37 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 72-74 metallothionein 1 Rattus norvegicus 39-43 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 86-88 metallothionein 1 Rattus norvegicus 20-37 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 86-88 metallothionein 1 Rattus norvegicus 39-43 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 86-88 metallothionein 1 Rattus norvegicus 20-37 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 86-88 metallothionein 1 Rattus norvegicus 39-43 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 86-88 metallothionein 1 Rattus norvegicus 20-37 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 86-88 metallothionein 1 Rattus norvegicus 39-43 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 86-88 metallothionein 1 Rattus norvegicus 20-37 16516943-5 2006 Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd(R) than in Cd(R)(-), which may account for the higher Cd-resistance of Cd(R) than Cd(R)(-). Cadmium 86-88 metallothionein 1 Rattus norvegicus 39-43 16516943-6 2006 MT-1 mRNA level decreased drastically in Cd(R) after cadmium removal, suggesting that the high basal level of MT-1 in Cd(R) may be only partially responsible for cadmium-resistance. Cadmium 53-60 metallothionein 1 Rattus norvegicus 0-4 16516943-6 2006 MT-1 mRNA level decreased drastically in Cd(R) after cadmium removal, suggesting that the high basal level of MT-1 in Cd(R) may be only partially responsible for cadmium-resistance. Cadmium 162-169 metallothionein 1 Rattus norvegicus 0-4 16516943-6 2006 MT-1 mRNA level decreased drastically in Cd(R) after cadmium removal, suggesting that the high basal level of MT-1 in Cd(R) may be only partially responsible for cadmium-resistance. Cadmium 162-169 metallothionein 1 Rattus norvegicus 110-114 15748513-10 2005 The expression of MT-1 and -2 were higher in the pancreas after cadmium administration. Cadmium 64-71 metallothionein 1 Rattus norvegicus 18-29 16226777-10 2006 MT-1 and MT-2 mRNA levels in kidney were substantially increased during treatment with Cd, being even higher when the animals received Cd and quercetin. Cadmium 87-89 metallothionein 1 Rattus norvegicus 0-13 16226777-10 2006 MT-1 and MT-2 mRNA levels in kidney were substantially increased during treatment with Cd, being even higher when the animals received Cd and quercetin. Cadmium 135-137 metallothionein 1 Rattus norvegicus 0-13 15795064-9 2005 This effect was more pronounced in the less exposed females fed from dams exposed to 10 ppb Cd, which also displayed lower hepatic metallothionein-1 (MT-1) mRNA levels. Cadmium 92-94 metallothionein 1 Rattus norvegicus 131-148 12604174-6 2003 It was noted that Cd administration resulted in a significant down-regulation in the expression of MT-I and MT-II mRNA in the rat ventral prostate. Cadmium 18-20 metallothionein 1 Rattus norvegicus 99-103 15249216-8 2004 On the basis of these results, we propose that MT-1 is related to the metabolism or detoxification of toxic metals such as Cd, and in contrast, MT-2 is responsible for the homeostasis of essential metals such as Cu. Cadmium 123-125 metallothionein 1 Rattus norvegicus 47-51 12854162-11 2003 In contrast, the mRNA levels in interstitial cells peaked at 6 h. Interestingly, the induction of MT1 mRNA was lower than MT2 mRNA in liver of rat treated with Cd, but it was opposite to interstitial cells. Cadmium 160-162 metallothionein 1 Rattus norvegicus 98-101 14694715-0 2002 [Effects of oral cadmium exposure on expression of metallothionein-I and metallothionein-II mRNA in rat prostate]. Cadmium 17-24 metallothionein 1 Rattus norvegicus 51-68 12642155-9 2003 Interestingly, the induction of MT1 mRNA was lower than MT2 mRNA in Sertoli cells and liver of rats treated with Cd. Cadmium 113-115 metallothionein 1 Rattus norvegicus 32-35 12642155-10 2003 However, the MT1 mRNA levels of spermatogenic cells decreased 0-3h after Cd treatment, followed by an increase; in contrast, MT2 mRNA levels increased 0-3h after Cd treatment, followed by a reduction, but induced extents of them are lower than those of Sertoli cells and liver. Cadmium 73-75 metallothionein 1 Rattus norvegicus 13-16 14694715-1 2002 OBJECTIVE: To investigate the possible effects of oral cadmium(Cd) exposure on the expression levels of metallothionein-I and metallothionein-II (MT-I and MT-II) mRNA and the distribution of zinc (Zn) and Cd in rat prostate. Cadmium 55-62 metallothionein 1 Rattus norvegicus 104-121 14694715-1 2002 OBJECTIVE: To investigate the possible effects of oral cadmium(Cd) exposure on the expression levels of metallothionein-I and metallothionein-II (MT-I and MT-II) mRNA and the distribution of zinc (Zn) and Cd in rat prostate. Cadmium 55-62 metallothionein 1 Rattus norvegicus 146-150 14694715-1 2002 OBJECTIVE: To investigate the possible effects of oral cadmium(Cd) exposure on the expression levels of metallothionein-I and metallothionein-II (MT-I and MT-II) mRNA and the distribution of zinc (Zn) and Cd in rat prostate. Cadmium 63-65 metallothionein 1 Rattus norvegicus 104-121 14694715-1 2002 OBJECTIVE: To investigate the possible effects of oral cadmium(Cd) exposure on the expression levels of metallothionein-I and metallothionein-II (MT-I and MT-II) mRNA and the distribution of zinc (Zn) and Cd in rat prostate. Cadmium 63-65 metallothionein 1 Rattus norvegicus 146-150 14694715-7 2002 It was also noted that Cd administration resulted in a significant down-regulation of the expression of MT-I and MT-II mRNA in rat ventral prostate. Cadmium 23-25 metallothionein 1 Rattus norvegicus 104-108 14694715-8 2002 In 200 mg/kg Cd group after one and six months, the relative expression levels of MT-I (0.410, 0.339 respectively) and MT-II (0.100, 0.112 respectively) were significantly lower than those of MT-I (0.760, 0.830 respectively) and MT-II (0.429, 0.439 respectively) in control group. Cadmium 13-15 metallothionein 1 Rattus norvegicus 82-86 14694715-8 2002 In 200 mg/kg Cd group after one and six months, the relative expression levels of MT-I (0.410, 0.339 respectively) and MT-II (0.100, 0.112 respectively) were significantly lower than those of MT-I (0.760, 0.830 respectively) and MT-II (0.429, 0.439 respectively) in control group. Cadmium 13-15 metallothionein 1 Rattus norvegicus 119-123 9152014-1 1997 This study examined cadmium-induced alterations in metallothionein-1 (MT), glutathione-S-transferase Ya (GST), and heme oxygenase-1 (HO) gene expression in an adult rat lung epithelial cell line. Cadmium 20-27 metallothionein 1 Rattus norvegicus 51-68 11430474-5 2001 These findings demonstrated that MT-I and MT-II mRNA were rapidly induced by Cd in dental pulp. Cadmium 77-79 metallothionein 1 Rattus norvegicus 33-37 11430474-10 2001 Furthermore, MT-I and/or MT-II in Cd-treated rat dental pulp was localized in odontoblasts, in which accumulation of Cd were reported. Cadmium 34-36 metallothionein 1 Rattus norvegicus 13-17 11430474-10 2001 Furthermore, MT-I and/or MT-II in Cd-treated rat dental pulp was localized in odontoblasts, in which accumulation of Cd were reported. Cadmium 117-119 metallothionein 1 Rattus norvegicus 13-17 11191077-12 2001 In cadmium-injected rats, MT I mRNA levels were significantly increased in the testis and initial segment, but there were no effects in the liver and other epididymal regions. Cadmium 3-10 metallothionein 1 Rattus norvegicus 26-30 10406082-9 1999 The expression of MT-I in the ventral prostate was not detected in the control group, but a weak expression was found after Cd exposure. Cadmium 124-126 metallothionein 1 Rattus norvegicus 18-22 12140172-6 2002 Cd treatment significantly increased renal MT-1 and MT-2 mRNA levels but protein was unaffected. Cadmium 0-2 metallothionein 1 Rattus norvegicus 43-56 11641042-3 2001 Both MT-I and MT-II mRNA levels were increased within 3 h by Cd administration. Cadmium 61-63 metallothionein 1 Rattus norvegicus 5-9 10647914-0 1999 Cadmium-induced apoptosis and changes in expression of p53, c-jun and MT-I genes in testes and ventral prostate of rats. Cadmium 0-7 metallothionein 1 Rattus norvegicus 70-74 10647914-1 1999 Apoptosis and a change in the expression of p53, c-jun and MT-I genes occurred in rats exposed to cadmium in a way known to cause carcinogenesis in testes and ventral prostate. Cadmium 98-105 metallothionein 1 Rattus norvegicus 59-63 10647914-11 1999 Although the MT-I gene was found to be expressed in all tissues, marked induction by cadmium of the expression of MT-I gene was only observed in the liver. Cadmium 85-92 metallothionein 1 Rattus norvegicus 114-118 10647914-12 1999 These results indicate: (1) that apoptosis is an early mechanism of acute tissue damage by cadmium in the testes and ventral prostate; (2) that p53 and c-jun genes may be involved in cadmium-induced cytotoxicity (apoptosis) and related carcinogenicity in male reproductive tissues; and (3) that the enhanced expression of MT-I in the liver could protect this organ from cadmium-induced cytotoxicity (apoptosis) and carcinogenicity. Cadmium 183-190 metallothionein 1 Rattus norvegicus 322-326 10647914-12 1999 These results indicate: (1) that apoptosis is an early mechanism of acute tissue damage by cadmium in the testes and ventral prostate; (2) that p53 and c-jun genes may be involved in cadmium-induced cytotoxicity (apoptosis) and related carcinogenicity in male reproductive tissues; and (3) that the enhanced expression of MT-I in the liver could protect this organ from cadmium-induced cytotoxicity (apoptosis) and carcinogenicity. Cadmium 183-190 metallothionein 1 Rattus norvegicus 322-326 9882588-5 1999 Cd treatment induced higher levels of MT-I and/or MT-II mRNA expression in all tissues studied with the exception of LP. Cadmium 0-2 metallothionein 1 Rattus norvegicus 38-42 9882588-6 1999 In the LP, Cd treatment caused reductions of MT-I and MT-II mRNA levels. Cadmium 11-13 metallothionein 1 Rattus norvegicus 45-49 9729479-4 1998 In the present study, we demonstrate that the rat testis indeed expresses Cd-binding proteins with sequences identical to those previously described for MT-1 and MT-2, the major isoforms. Cadmium 74-76 metallothionein 1 Rattus norvegicus 153-166 9729479-5 1998 To confirm that MT-1 and MT-2 are present in the rat testis, we purified and isolated Cd-binding proteins by homogenization using Cd-containing buffer, followed by sequential purification using Sephadex G-75 gel filtration chromatography and anion HPLC column chromatography, which yielded Cd-binding protein-1 (Cd-BP-1) and -2 (Cd-BP-2). Cadmium 86-88 metallothionein 1 Rattus norvegicus 16-29 9729479-6 1998 After pyridylethylation, Cd-BP-1 and Cd-BP-2 were subjected to specific protein fragmentation by acids and endopeptidases, which revealed that these Cd-binding proteins have the same primary structures as MT-1 and MT-2 respectively. Cadmium 25-27 metallothionein 1 Rattus norvegicus 205-218 9152014-2 1997 Elevations in MT mRNA and HO mRNA occurred as early as 1 h after exposure to a sub-toxic concentration of CdCl(2) (10 microM) whereas GST expression did not increase significantly until 4 h after Cd addition. Cadmium 106-108 metallothionein 1 Rattus norvegicus 14-16 9152014-6 1997 The MT gene was more responsive to low Cd concentrations (5 microM) than the genes for HO or GST whereas HO was induced more than the others at higher Cd doses (10-20 microM). Cadmium 39-41 metallothionein 1 Rattus norvegicus 4-6 9152014-6 1997 The MT gene was more responsive to low Cd concentrations (5 microM) than the genes for HO or GST whereas HO was induced more than the others at higher Cd doses (10-20 microM). Cadmium 151-153 metallothionein 1 Rattus norvegicus 4-6 9152014-9 1997 Depleting GSH by treatment of cells with buthionine sulfoximine (BSO) enhanced Cd-induced expression of MT, GST, and HO whereas thiol supplementation, by treatment with N-acetyl cysteine (NAC), had an attenuating effect. Cadmium 79-81 metallothionein 1 Rattus norvegicus 104-106 9152014-11 1997 In summary, this study has shown that: (1) Cd increases MT, GST, and HO gene expression in a time- and dose-dependent fashion: (2) MT gene expression appears to be most sensitive to Cd whereas the HO gene is most inducible at higher Cd concentrations; (3) Cd-induced expression is enhanced by GSH depletion and suppressed by thiol supplementation. Cadmium 43-45 metallothionein 1 Rattus norvegicus 56-58 9152014-11 1997 In summary, this study has shown that: (1) Cd increases MT, GST, and HO gene expression in a time- and dose-dependent fashion: (2) MT gene expression appears to be most sensitive to Cd whereas the HO gene is most inducible at higher Cd concentrations; (3) Cd-induced expression is enhanced by GSH depletion and suppressed by thiol supplementation. Cadmium 43-45 metallothionein 1 Rattus norvegicus 131-133 9152014-11 1997 In summary, this study has shown that: (1) Cd increases MT, GST, and HO gene expression in a time- and dose-dependent fashion: (2) MT gene expression appears to be most sensitive to Cd whereas the HO gene is most inducible at higher Cd concentrations; (3) Cd-induced expression is enhanced by GSH depletion and suppressed by thiol supplementation. Cadmium 182-184 metallothionein 1 Rattus norvegicus 131-133 9152014-11 1997 In summary, this study has shown that: (1) Cd increases MT, GST, and HO gene expression in a time- and dose-dependent fashion: (2) MT gene expression appears to be most sensitive to Cd whereas the HO gene is most inducible at higher Cd concentrations; (3) Cd-induced expression is enhanced by GSH depletion and suppressed by thiol supplementation. Cadmium 182-184 metallothionein 1 Rattus norvegicus 131-133 9152014-11 1997 In summary, this study has shown that: (1) Cd increases MT, GST, and HO gene expression in a time- and dose-dependent fashion: (2) MT gene expression appears to be most sensitive to Cd whereas the HO gene is most inducible at higher Cd concentrations; (3) Cd-induced expression is enhanced by GSH depletion and suppressed by thiol supplementation. Cadmium 182-184 metallothionein 1 Rattus norvegicus 131-133 9152014-1 1997 This study examined cadmium-induced alterations in metallothionein-1 (MT), glutathione-S-transferase Ya (GST), and heme oxygenase-1 (HO) gene expression in an adult rat lung epithelial cell line. Cadmium 20-27 metallothionein 1 Rattus norvegicus 70-72 8599171-8 1996 TICs isolated from Cd-treated rats accumulated more Cd (4-fold), and had higher levels of MT-I (1.9-fold) and MT-II (1.4-fold) mRNAs over control, but contained less MT (30% decrease) than TICs isolated from control animals. Cadmium 19-21 metallothionein 1 Rattus norvegicus 90-94 8615845-1 1996 The expression of metallothionein (MT)-1 and -2 mRNAs in rat liver following administration of Cd or Cu was investigated using specific oligonucleotides. Cadmium 95-97 metallothionein 1 Rattus norvegicus 18-47 8599171-9 1996 Cd exposure substantially increased hepatic Cd content (6000-fold), MT (58-fold), and MT-I mRNA (5.3-fold), but did not increase MT-II mRNA. Cadmium 0-2 metallothionein 1 Rattus norvegicus 86-90 7597713-11 1995 Following Cd administration, the level of MT-1 mRNA and MT-2 mRNA increased in each cell class but the response to Cd was three times greater in alveolar macrophages. Cadmium 10-12 metallothionein 1 Rattus norvegicus 42-46 7597713-15 1995 In conclusion, the present study has demonstrated that (1) alveolar macrophages and type II cells respond to in vivo Cd exposure by increasing MT protein and mRNA levels; (2) MT expression is greater in macrophages than in type II cells and correlates well with intracellular Cd concentration; and (3) the MT-2 mRNA to MT-1 mRNA ratio is cell and treatment specific. Cadmium 117-119 metallothionein 1 Rattus norvegicus 319-323 7747280-10 1995 Dose-response analysis 24 hr after cadmium administration (0.25 to 40 mumol/kg, sc) showed that MT-I and MT-II mRNA levels were increased in liver in a dose-dependent manner, while no evidence was found for MT gene activation in ventral prostate. Cadmium 35-42 metallothionein 1 Rattus norvegicus 96-100 8301701-8 1994 In addition, a 24-h exposure to low-concentration cadmium resulted in an increase in MT-I gene expression. Cadmium 50-57 metallothionein 1 Rattus norvegicus 85-89 2235487-6 1990 The cadmium-dependent factor dissociates more rapidly from the MT-I promoter than does a factor that binds to a consensus Sp1 site present on the same DNA fragment. Cadmium 4-11 metallothionein 1 Rattus norvegicus 63-67 1733046-5 1992 Atomic absorption spectrometry was utilized to measure the Zn, Cu, and Cd contents of MT-1 and MT-2 obtained in selected experimental groups. Cadmium 71-73 metallothionein 1 Rattus norvegicus 86-99 1779092-2 1991 Cadmium-containing rat MT-I and -II were subjected to sodium dodecylsulfate/polyacrylamide gel electrophoresis (SDS-PAGE) without prior reduction by 2-mercaptoethanol (2-ME), because prior reduction of MTs by 2-ME resulted in diffused bands. Cadmium 0-7 metallothionein 1 Rattus norvegicus 23-35 1716322-6 1991 Liver MT gene expression was substantially induced following chronic Cd exposure, while kidney was not, although this organ had a higher basal expression of the MT-1 gene. Cadmium 69-71 metallothionein 1 Rattus norvegicus 161-165 2219126-3 1990 After a single injection of Cd salts, concentrations of MT and MT-1 mRNA were significantly increased in liver as compared to control. Cadmium 28-36 metallothionein 1 Rattus norvegicus 63-67 2219126-8 1990 When Zn injection was preceded by a Cd injection, induction as measured by MT-1 mRNA and MT concentrations were approximately additive in liver. Cadmium 36-38 metallothionein 1 Rattus norvegicus 75-79 2219126-9 1990 In kidney, although Cd or Zn treatment separately had no effect on MT or MT-1 mRNA content, injection of Cd followed by Zn resulted in significantly increased levels of renal MT and MT-1 mRNA. Cadmium 105-107 metallothionein 1 Rattus norvegicus 182-186 2484577-5 1989 Cd treatment increased MT-I and MT-II to similar concentrations. Cadmium 0-2 metallothionein 1 Rattus norvegicus 23-27 3341019-10 1988 Additional experiments indicated that Cd (1-30 mumol/kg), Zn (100-3000 mumol/kg), and dexamethasone (0.3-10 mumol/kg) increased hepatic concentrations of MT-I and MT-II and their respective mRNAs in 14-day-old rats, despite the preexisting high levels of protein and mRNA at this time. Cadmium 38-40 metallothionein 1 Rattus norvegicus 154-158 2728004-0 1989 Urinary excretion of metallothionein-I and its degradation product in rats treated with cadmium, copper, zinc or mercury. Cadmium 88-95 metallothionein 1 Rattus norvegicus 21-38 2728004-1 1989 The metallothionein-I (MT-I) content of urine following administration of cadmium (Cd), copper (Cu), mercury (Hg) or zinc (Zn) to rats was determined by radioimmunoassay. Cadmium 74-81 metallothionein 1 Rattus norvegicus 4-21 2728004-1 1989 The metallothionein-I (MT-I) content of urine following administration of cadmium (Cd), copper (Cu), mercury (Hg) or zinc (Zn) to rats was determined by radioimmunoassay. Cadmium 74-81 metallothionein 1 Rattus norvegicus 23-27 2728004-3 1989 Fractionation of urine from Cd-treated rats on Sephadex G-50 showed a single immunoreactive component corresponding to native MT-I, whereas in urine from Cu, Zn or Hg-treated rats 2 immunoreactive components corresponding to MT-I and a possible degradation production were observed. Cadmium 28-30 metallothionein 1 Rattus norvegicus 126-130 3341019-12 1988 In 14-day-old neonates, MT-I and MT-II genes are responsive to Cd, Zn, and dexamethasone when constitutive levels of both MT mRNA and isoproteins are high. Cadmium 63-65 metallothionein 1 Rattus norvegicus 24-28 3431545-8 1987 Moreover, cadmium, a potent transcriptional activator of the MT-I gene, does not alter the sensitivity of the MT-I gene to MNase. Cadmium 10-17 metallothionein 1 Rattus norvegicus 61-65 3683394-1 1987 Using the technique of genomic footprinting, we demonstrate cadmium-inducible protection from dimethyl sulfate (DMS) modification of guanine residues in vivo in five metal-responsive elements (MREs) in the promoter of the rat metallothionein 1 (MT-1) gene. Cadmium 60-67 metallothionein 1 Rattus norvegicus 226-243 3683394-1 1987 Using the technique of genomic footprinting, we demonstrate cadmium-inducible protection from dimethyl sulfate (DMS) modification of guanine residues in vivo in five metal-responsive elements (MREs) in the promoter of the rat metallothionein 1 (MT-1) gene. Cadmium 60-67 metallothionein 1 Rattus norvegicus 245-249 3564038-0 1987 Induction of metallothionein-I and metallothionein-II in rats by cadmium and zinc. Cadmium 65-72 metallothionein 1 Rattus norvegicus 13-30 3564038-4 1987 In liver, Cd treatment increased MTs at all dosages tested such that concentrations of MT-I and MT-II were approximately equal. Cadmium 10-12 metallothionein 1 Rattus norvegicus 87-91 3564038-10 1987 Thus, in liver and kidney, Cd induced MT-I and MT-II similarly over a wide range of dosages. Cadmium 27-29 metallothionein 1 Rattus norvegicus 38-42 3309208-1 1987 These studies were designed to investigate the effects of low dietary zinc, copper or selenium intake of certain types of stress and of injection of zinc, copper or cadmium on metallothionein I (MT-I) concentrations in the blood and urine of rats. Cadmium 165-172 metallothionein 1 Rattus norvegicus 176-193 3309208-1 1987 These studies were designed to investigate the effects of low dietary zinc, copper or selenium intake of certain types of stress and of injection of zinc, copper or cadmium on metallothionein I (MT-I) concentrations in the blood and urine of rats. Cadmium 165-172 metallothionein 1 Rattus norvegicus 195-199 3309208-4 1987 Injection of zinc and also of cadmium and copper had the opposite effect and increased MT-I concentrations in both samples, although the effects of zinc on blood cells and urine were relatively transient. Cadmium 30-37 metallothionein 1 Rattus norvegicus 87-91