PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24444374-10 2014 CONCLUSION: Copper metabolism and antioxidant enzymes maintain the function of Ycf1p for cadmium defense. Cadmium 89-96 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 79-84 24444374-0 2014 YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes. Cadmium 14-21 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 0-4 23062827-5 2013 The YCF1-expressing transgenic poplar plants exhibited enhanced growth, reduced toxicity symptoms, and increased Cd content in the aerial tissue compared to the non-transgenic plants. Cadmium 113-115 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 4-8 24444374-5 2014 Intriguingly, CCS1 encoding the copper chaperone for superoxide dismutase 1 (Sod1p) is necessary for cadmium resistance that is mediated by Ycf1p, a vacuolar cadmium sequestration transporter. Cadmium 101-108 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 140-145 24444374-5 2014 Intriguingly, CCS1 encoding the copper chaperone for superoxide dismutase 1 (Sod1p) is necessary for cadmium resistance that is mediated by Ycf1p, a vacuolar cadmium sequestration transporter. Cadmium 158-165 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 140-145 18667437-6 2008 Mutant Ycf1p-S251A exhibits increased resistance to cadmium in vivo and increased Ycf1p-dependent transport of [(3)H]estradiol-beta-17-glucuronide in vitro as compared with wild-type Ycf1p. Cadmium 52-59 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 7-12 20835888-5 2011 Analysis of the expression of four genes (GLR1, GTT2, GSH1, and YCF1) that aid in transporting heavy metal (Cd(2+)) from the cytoplasm to the vacuole demonstrated that none of these genes were induced under Cd(2+), Zn(2+), Cu(2+), and NaCl stress in ThMT3-transgenic yeast. Cadmium 108-110 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 64-68 20016005-5 2010 This cadmium sensitivity results from loss of normal activity of a vacuolar ATP-binding cassette transporter protein called Ycf1. Cadmium 5-12 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 124-128 18602772-0 2008 The role of the yeast ATP-binding cassette Ycf1p in glutathione and cadmium ion homeostasis during respiratory metabolism. Cadmium 68-75 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 43-48 17644279-6 2007 Confirming this hypothesis, a mutant strain deficient in Ycf1, which present high concentrations of GSH-cadmium in cytoplasm due to its deficiency in transport the complex to vacuole, showed increased mutation rates. Cadmium 104-111 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 57-61 16814918-7 2006 All together, these results suggest that in addition to being accumulated in the yeast vacuole by Ycf1p, cadmium is also effluxed out of the cell by Yor1p. Cadmium 105-112 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 98-103 14994274-4 2004 We observed that the deficiency of Sod1 increases the expression of both Cup1 (a metallothionein) and Ycf1 (a vacuolar glutathione S-conjugate pump), proteins involved with protection against cadmium. Cadmium 192-199 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 102-106 15556603-0 2004 Ycf1-dependent cadmium detoxification by yeast requires phosphorylation of residues Ser908 and Thr911. Cadmium 15-22 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 0-4 15556603-5 2004 Mutation of these residues to alanine severely impaired the Ycf1-dependent cadmium detoxification capacity and transport activity, while replacement by acidic residues (mimicking phosphorylation) significantly suppressed the cadmium resistance and transport defects. Cadmium 75-82 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 60-64 15556603-8 2004 Our data strongly implicate Ycf1 phosphorylation as a key determinant in cadmium resistance in yeast, a significant finding given that very little is known about phosphorylation of ABC transporters in yeast. Cadmium 73-80 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 28-32 14729212-3 2004 has shown that overexpressing the yeast vacuolar transporter YCF1 increases Pb and Cd tolerance and consequently increases the accumulation of these metals in shoots of transgenic Arabidopsis plants even though expression levels of YCF1 were relatively low. Cadmium 83-85 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 61-65 12872132-1 2003 We have studied the utility of the yeast protein YCF1, which detoxifies cadmium by transporting it into vacuoles, for the remediation of lead and cadmium contamination. Cadmium 72-79 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 49-53 12872132-1 2003 We have studied the utility of the yeast protein YCF1, which detoxifies cadmium by transporting it into vacuoles, for the remediation of lead and cadmium contamination. Cadmium 146-153 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 49-53 12872132-3 2003 DTY167 cells overexpressing YCF1 were more resistant to Pb(II) and Cd(II) than were wild-type cells, and accumulated more lead and cadmium. Cadmium 131-138 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 28-32 12872132-5 2003 These results suggest that transgenic plants expressing YCF1 may be useful for phytoremediation of lead and cadmium. Cadmium 108-115 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 56-60 12475964-2 2002 Ycf1p resides in the vacuolar membrane and mediates glutathione-dependent transport processes that result in resistance to cadmium and other xenobiotics. Cadmium 123-130 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 0-5 12796304-1 2003 Ycf1p, a member of the yeast multidrug resistance-associated protein (MRP) subfamily of ATP-binding cassette proteins, is a vacuolar membrane transporter that confers resistance to a variety of toxic substances such as cadmium and arsenite. Cadmium 219-226 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 0-5 12796304-6 2003 Instead, the L6(ins) appears to regulate substrate specificity of Ycf1p, since certain mutations in this region lower cellular cadmium resistance with a concomitant gain in arsenite resistance. Cadmium 127-134 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 66-71 12383937-5 2002 Cadmium is compartmentalized in vacuoles through the Ycf1 transporter, in the form of a bis-glutathionato-cadmium complex. Cadmium 0-7 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 53-57 10438540-1 1999 The yeast cadmium factor (Ycf1p) is a vacuolar protein involved in resistance to Cd(2+) and to exogenous glutathione S-conjugate precursors in yeast. Cadmium 81-83 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 26-31 12455987-7 2002 Whereas YCF1 expression is markedly increased by cadmium, adenine limitation in an ade2 strain, or overexpression of the stress-responsive transcription factor Yap1p, BPT1 expression is only modestly affected under these conditions. Cadmium 49-56 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 8-12 10753671-1 2000 YCF1 is a yeast vacuole membrane transporter involved in resistance to Cd(2+) and to exogenous glutathione S-conjugate precursors. Cadmium 71-73 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 0-4 8663018-9 1996 Yrs1 had an overlapping specificity with Ycf1 in the resistance to cadmium. Cadmium 67-74 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 41-45 9681016-1 1998 An ABC-transporter of Arabidopsis thaliana exhibiting high sequence similarity to the human (MRP1) and yeast (YCF1) glutathione-conjugate transporters has been analysed and used to complement a cadmium-sensitive yeast mutant (DTY168) that also lacks glutathione-conjugate transport activity. Cadmium 194-201 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 110-114 8990158-0 1997 A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Cadmium 27-34 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 78-82 8990158-2 1997 However, while YCF1 was originally isolated according to its ability to confer resistance to cadmium salts, neither its mode of interaction with Cd2+ nor the relationship between this process and organic glutathione-conjugate transport are known. Cadmium 93-106 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 15-19 8990158-4 1997 The substrate requirements, kinetics and Cd2+/glutathione stoichiometry of cadmium uptake and the molecular weight of the transport-active complex demonstrate that YCF1 selectively catalyzes the transport of bis(glutathionato)cadmium (Cd x +GS2). Cadmium 75-82 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 164-168 7521334-2 1994 The yeast cadmium factor (YCF1) gene from Saccharomyces cerevisiae is required for cadmium resistance and encodes a 1,515 amino acid protein with extensive homology to both the human multidrug resistance-associated protein (MRP1) and the cystic fibrosis transmembrane conductance regulator (hCFTR). Cadmium 10-17 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 26-30 8692889-1 1996 A Saccharomyces cerevisiae strain with a disrupted yeast cadmium resistance factor (YCF1) gene (DTY168) is hypersensitive to cadmium. Cadmium 57-64 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 84-88 8692889-7 1996 Our results indicate that yeast YCF1 is a glutathione S-conjugate pump, like MRP, and they raise the possibility that the cadmium resistance in yeast involves cotransport of cadmium with glutathione derivatives. Cadmium 122-129 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 32-36 8692889-7 1996 Our results indicate that yeast YCF1 is a glutathione S-conjugate pump, like MRP, and they raise the possibility that the cadmium resistance in yeast involves cotransport of cadmium with glutathione derivatives. Cadmium 174-181 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 32-36 7798263-0 1994 Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1. Cadmium 0-7 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 129-133 7798263-3 1994 We show here that the YCF1 gene, encoding a likely integral membrane protein, is required for yAP-1 to exert its normal effects on cadmium tolerance. Cadmium 131-138 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 22-26 7798263-4 1994 Mutant strains of yeast that lack the YCF1 gene are hypersensitive to cadmium and this hypersensitivity is epistatic to yAP-1 overexpression. Cadmium 70-77 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 38-42 8626454-1 1996 The yeast cadmium factor gene (YCF1) from Saccharomyces cerevisiae, which was isolated according to its ability to confer cadmium resistance, encodes a 1,515 amino acid ATP-binding cassette (ABC) protein with extensive sequence homology to the human multidrug resistance-associated protein (MRP1) (Szczypka, M., Wemmie, J. Cadmium 10-17 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 31-35 8626454-6 1996 Direct comparisons between S. cerevisiae strain DTY167, harboring a deletion of the YCF1 gene, and the isogenic wild type strain, DTY165, demonstrate that YCF1 is required for increased resistance to the toxic effects of the exogenous glutathione S-conjugate precursor, 1-chloro-2,4-di-nitrobenzene, as well as cadmium. Cadmium 311-318 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 84-88 8626454-6 1996 Direct comparisons between S. cerevisiae strain DTY167, harboring a deletion of the YCF1 gene, and the isogenic wild type strain, DTY165, demonstrate that YCF1 is required for increased resistance to the toxic effects of the exogenous glutathione S-conjugate precursor, 1-chloro-2,4-di-nitrobenzene, as well as cadmium. Cadmium 311-318 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 155-159 7521334-4 1994 Mutagenesis experiments demonstrate that conserved amino acid residues, functionally critical in hCFTR, play a vital role in YCF1-mediated cadmium resistance. Cadmium 139-146 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 125-129 7521334-5 1994 Mutagenesis of phenylalanine 713 in the YCF1 nucleotide binding fold 1, which correlates with the delta F508 mutation found in the most common form of cystic fibrosis, completely abolished YCF1 function in cadmium detoxification. Cadmium 206-213 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 40-44 7521334-3 1994 S. cerevisiae cells harboring a deletion of the YCF1 gene are hypersensitive to cadmium compared with wild type cells. Cadmium 80-87 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 48-52 7521334-5 1994 Mutagenesis of phenylalanine 713 in the YCF1 nucleotide binding fold 1, which correlates with the delta F508 mutation found in the most common form of cystic fibrosis, completely abolished YCF1 function in cadmium detoxification. Cadmium 206-213 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 189-193 34638819-8 2021 What excites us is that by introducing StMTPs 8/9 into the ycf1 yeast cadmium-sensitive mutant strain, the functional complementation experiment proved that StMTPs 8/9 can restore Cd tolerance. Cadmium 71-78 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 60-64 34874779-9 2021 An ABC transporter gene in E. coli, possibly homologous to the yeast ycf1, was heterologously expressed in S. cerevisiae, resulting in enhanced Cd tolerance. Cadmium 144-146 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 69-73 34638819-8 2021 What excites us is that by introducing StMTPs 8/9 into the ycf1 yeast cadmium-sensitive mutant strain, the functional complementation experiment proved that StMTPs 8/9 can restore Cd tolerance. Cadmium 181-183 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 60-64 34086824-3 2021 A cDNA library constructed from roots of B. rapa plants treated with Cd was transformed into the Cd sensitive yeast mutant strain DTY167 that lacks the yeast cadmium factor (YCF1), and resistant yeast clones were selected on Cd containing media. Cadmium 69-71 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 174-178 33276998-6 2021 Expression of OsMT1e in a yeast Cd-sensitive strain ycf1 conferred cellular tolerance to Cd, even though the ycf1 + OsMT1e cells accumulated more Cd than the control cells (ycf1 + pYES2). Cadmium 32-34 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 52-56 33276998-6 2021 Expression of OsMT1e in a yeast Cd-sensitive strain ycf1 conferred cellular tolerance to Cd, even though the ycf1 + OsMT1e cells accumulated more Cd than the control cells (ycf1 + pYES2). Cadmium 89-91 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 52-56 33276998-6 2021 Expression of OsMT1e in a yeast Cd-sensitive strain ycf1 conferred cellular tolerance to Cd, even though the ycf1 + OsMT1e cells accumulated more Cd than the control cells (ycf1 + pYES2). Cadmium 89-91 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 52-56