PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17610031-9	2008	In IHH and NHH, cadmium 100 micromol/L induced PARP cleavage into a 85 kDa fragment.	Cadmium	16-23	poly(ADP-ribose) polymerase 1	Homo sapiens	47-51	
11864456-6	1999	Low levels of the two kinds of metal (0.10 - 0.40 micromol/L of nickel and 0.16 micromol/L of cadmium) could induce the cleavage of DNA and activate PARP, and high levels of the two kinds of metal (2.00 - 10.00 micromol/L of nickel and 0.80 - 20.00 micromol/L of cadmium) could not induce the enzyme cleavage of DNA.	Cadmium	94-101	poly(ADP-ribose) polymerase 1	Homo sapiens	149-153	
33321290-4	2021	HK-2 cells treated with Cd induced the expression of p53, DNA damage autophagy modulator (DRAM), and Bcl-2-associated X protein (BAX), as well as caused poly [ADP-ribose] polymerase 1 (PARP-1) cleavage.	Cadmium	24-26	poly(ADP-ribose) polymerase 1	Homo sapiens	153-183	
33321290-4	2021	HK-2 cells treated with Cd induced the expression of p53, DNA damage autophagy modulator (DRAM), and Bcl-2-associated X protein (BAX), as well as caused poly [ADP-ribose] polymerase 1 (PARP-1) cleavage.	Cadmium	24-26	poly(ADP-ribose) polymerase 1	Homo sapiens	185-191	
27620489-7	2016	In both cell lines, Cd exposure resulted in caspase-3-mediated PARP-1 cleavage and the induction of CHOP, LC3-II, and HO-1, which were limited in YD10B and H1299 cells exposed to high concentrations of Cd.	Cadmium	20-22	poly(ADP-ribose) polymerase 1	Homo sapiens	63-69	
32872665-4	2020	CD-induced overproduction of reactive oxygen species and reduced mitochondrial membrane potential, associated with reduced expression of Bcl-2 and increased levels of cytosolic cytochrome c, cleaved PARP-1 and caspase-3.	Cadmium	0-2	poly(ADP-ribose) polymerase 1	Homo sapiens	199-205	
27620489-9	2016	The inhibition of autophagy using small interfering RNA (siRNA) for the autophagy-related gene atg5 enhanced HO-1, CHOP, and PARP-1 cleavage induced by Cd.	Cadmium	152-154	poly(ADP-ribose) polymerase 1	Homo sapiens	125-131	
31079487-11	2019	The cytoprotective effects of Tax against Cd-induced apoptosis were also characterized by the changes in the activity of caspase 3, -7, poly ADP-ribose polymerase, the cellular proliferation-related ERK1/2, and AKT.	Cadmium	42-44	poly(ADP-ribose) polymerase 1	Homo sapiens	121-162	
26381174-6	2015	In dose-response experiments, cleavage of procaspase-3, PARP-1, and LC3-II was induced by Cd with an IC50 of 45 muM.	Cadmium	90-92	poly(ADP-ribose) polymerase 1	Homo sapiens	56-62	
23405080-5	2013	Cd also increased intracellular reactive oxygen species (ROS) generation and malondialdehyde (MDA) production and induced mitochondrial dysfunction (the loss of mitochondrial membrane potential (MMP) and the increase of cytosolic cytochrome c release), the decreased Bcl-2 expression, increased p53 expression, poly (ADP-ribose) polymerase (PARP) cleavage, and caspase cascades, which accompanied with intracellular Cd accumulation.	Cadmium	0-2	poly(ADP-ribose) polymerase 1	Homo sapiens	311-339	
25480692-7	2015	We found that higher nuclear PARP1 (nPARP1) expression correlated with increased in vitro chemosensitivity against docetaxel (p=0.001) and epirubicin (p=0.022) based on CD-DST results.	Cadmium	169-171	poly(ADP-ribose) polymerase 1	Homo sapiens	29-34	
23405080-5	2013	Cd also increased intracellular reactive oxygen species (ROS) generation and malondialdehyde (MDA) production and induced mitochondrial dysfunction (the loss of mitochondrial membrane potential (MMP) and the increase of cytosolic cytochrome c release), the decreased Bcl-2 expression, increased p53 expression, poly (ADP-ribose) polymerase (PARP) cleavage, and caspase cascades, which accompanied with intracellular Cd accumulation.	Cadmium	0-2	poly(ADP-ribose) polymerase 1	Homo sapiens	341-345	
21767558-8	2011	In addition, cadmium generated reactive oxygen species (ROS) at relatively low levels, and caused poly(ADP-ribose) polymerase-1 (PARP) activation and ATP depletion.	Cadmium	13-20	poly(ADP-ribose) polymerase 1	Homo sapiens	98-127	
21767558-8	2011	In addition, cadmium generated reactive oxygen species (ROS) at relatively low levels, and caused poly(ADP-ribose) polymerase-1 (PARP) activation and ATP depletion.	Cadmium	13-20	poly(ADP-ribose) polymerase 1	Homo sapiens	129-133	
21767558-9	2011	Inhibition of PARP by pharmacological inhibitors or its siRNA transfection suppressed ATP reduction and autophagy in cadmium-exposed cells.	Cadmium	117-124	poly(ADP-ribose) polymerase 1	Homo sapiens	14-18	
21767558-11	2011	Consequently, these results suggest that cadmium-mediated ROS generation causes PARP activation and energy depletion, and eventually induces autophagy through the activation of LKB1-AMPK signaling and the down-regulation of mTOR in skin epidermal cells.	Cadmium	41-48	poly(ADP-ribose) polymerase 1	Homo sapiens	80-84