PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24928356-1 2014 N-acetyltransferase (NAT2) is a phase-II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines, aromatic amines and hydrazines. aromatic amines 129-144 N-acetyltransferase 2 Homo sapiens 21-25 22092501-2 2012 Polymorphisms at N-acetyltransferase 2 locus, coding for an enzyme catalyzing acetylation of aromatic amines, might cause DNA adduct formation because of improper acetylation of these polyaromatic hydrocarbons. aromatic amines 93-108 N-acetyltransferase 2 Homo sapiens 17-38 24595082-1 2013 N-acetyltransferase 2 (NAT2) gene encodes a phase II enzyme taking part in detoxification of aromatic amines. aromatic amines 93-108 N-acetyltransferase 2 Homo sapiens 23-27 24791559-4 2014 The NAT2 genotype may modify the risk of cancer by activating or detoxifying heterocyclic and aromatic amines. aromatic amines 94-109 N-acetyltransferase 2 Homo sapiens 4-8 24595082-1 2013 N-acetyltransferase 2 (NAT2) gene encodes a phase II enzyme taking part in detoxification of aromatic amines. aromatic amines 93-108 N-acetyltransferase 2 Homo sapiens 0-21 20568013-1 2011 N-acetyltransferase 2 (NAT2) is phase II enzyme with major roles in catalyzing the detoxification of aromatic amines, which are known risk factors for bladder cancer, and are ubiquitously present in the environment. aromatic amines 101-116 N-acetyltransferase 2 Homo sapiens 0-21 20568013-1 2011 N-acetyltransferase 2 (NAT2) is phase II enzyme with major roles in catalyzing the detoxification of aromatic amines, which are known risk factors for bladder cancer, and are ubiquitously present in the environment. aromatic amines 101-116 N-acetyltransferase 2 Homo sapiens 23-27 15450435-10 2004 These results could provide evidence that the bladder carcinogenic aromatic amines are mainly activated by the NAT1 enzyme to produce DNA damage rather than NAT2. aromatic amines 67-82 N-acetyltransferase 2 Homo sapiens 157-161 19248797-5 2009 Exposure of these cells to pathophysiologically relevant amounts of oxidants known to contribute to lung dysfunction, such as H(2)O(2) or peroxynitrite, was found to impair the NAT1/Nat2-dependent cellular biotransformation of aromatic amines. aromatic amines 227-242 N-acetyltransferase 2 Homo sapiens 182-186 16372832-0 2005 Heterologous co-expression of human cytochrome P450 1A2 and polymorphic forms of N-acetyltransferase 2 for studies on aromatic amines in V79 Chinese hamster cells. aromatic amines 118-133 N-acetyltransferase 2 Homo sapiens 81-102 15122594-3 2004 Two N-acetyltransferase isozymes, NAT2 and NAT1, have major roles in catalyzing the N-acetylation and O-acetylation of aromatic amines. aromatic amines 119-134 N-acetyltransferase 2 Homo sapiens 34-38 15122594-15 2004 NAT2 slow acetylator was associated with marginally increased risk of bladder cancer (OR = 1.50, 95% CI = 0.99-2.27), and the OR for the joint effect with occupational exposure of aromatic amines was 3.26 (95% CI = 1.06-9.95). aromatic amines 180-195 N-acetyltransferase 2 Homo sapiens 0-4 11266080-1 2001 The highly polymorphic N-acetyltransferases (NAT1 and NAT2) are involved in both activation and inactivation reactions of numerous carcinogens, such as tobacco derived aromatic amines. aromatic amines 168-183 N-acetyltransferase 2 Homo sapiens 54-58 12877350-2 2003 N-acetyltransferase (NAT2) is involved in the metabolic activation and detoxification of aromatic amines. aromatic amines 89-104 N-acetyltransferase 2 Homo sapiens 21-25 12872524-14 2003 In the pathogenesis of human bladder cancer due to occupational exposure to "classical" aromatic amines (benzidine, 4-aminodiphenyl, 1-naphthylamine) acetylation by NAT2 is regarded as a detoxication step. aromatic amines 88-103 N-acetyltransferase 2 Homo sapiens 165-169 11869833-0 2002 The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: a review considering ethnic differences. aromatic amines 76-91 N-acetyltransferase 2 Homo sapiens 46-50 11603126-1 2001 AIM: This study was designed to evaluate the impact of N-acetyltransferase 2 (NAT2, substrate: aromatic amines) in painters with bladder cancer and controls. aromatic amines 95-110 N-acetyltransferase 2 Homo sapiens 55-76 11598453-1 2001 INTRODUCTION/OBJECTIVE: N-acetyltransferase 2 (NAT2), mapped to 8p22, is a polymorphic enzyme which metabolizes aromatic amines. aromatic amines 112-127 N-acetyltransferase 2 Homo sapiens 24-45 11598453-1 2001 INTRODUCTION/OBJECTIVE: N-acetyltransferase 2 (NAT2), mapped to 8p22, is a polymorphic enzyme which metabolizes aromatic amines. aromatic amines 112-127 N-acetyltransferase 2 Homo sapiens 47-51 10815690-2 2000 The ability to detoxify aromatic amines, which are present in tobacco and are potent bladder carcinogens, is compromised in persons with the N-acetyltransferase 2 slow acetylation polymorphism. aromatic amines 24-39 N-acetyltransferase 2 Homo sapiens 141-162 10868688-3 2000 N-acetyltransferases, encoded by the NAT1 and NAT2 genes are involved in the biotransformation of aromatic amines present in tobacco smoke, environment, and diet. aromatic amines 98-113 N-acetyltransferase 2 Homo sapiens 46-50 10599336-5 1999 NAT-2 is the most important enzyme in acetylation of aromatic amines, and thus may be responsible for detoxification of many of these compounds. aromatic amines 53-68 N-acetyltransferase 2 Homo sapiens 0-5 8643532-1 1996 Several epidemiologic studies indicate that NAT2-related slow N-acetylation increases bladder cancer risk among workers exposed to aromatic amines, presumably because N-acetylation is important for the detoxification of these compounds. aromatic amines 131-146 N-acetyltransferase 2 Homo sapiens 44-48 9891107-1 1997 The study was designed to assess occupational and non-occupational risk factors in patients with urothelial carcinomas in an area of former coal, iron, and steel industries, with special regard to the impacts of polymorphic enzymes involved in the metabolism of aromatic amines (N-acetyltransferase 2, NAT2) and of polycyclic aromatic hydrocarbons (glutathione S-transferase micro, GSTM1). aromatic amines 262-277 N-acetyltransferase 2 Homo sapiens 279-300 9806162-2 1998 The aromatic amines and their metabolites, a class of carcinogens present in tobacco smoke, undergo metabolism (activation or detoxification) through an N- or O-acetylation pathway by the polymorphic enzymes, N-acetyltransferases (NAT)1 or NAT2. aromatic amines 4-19 N-acetyltransferase 2 Homo sapiens 240-244 8761425-7 1996 Our results suggest that smoking coke oven workers with genotypes unfavourable for detoxification of aromatic amines (NAT2-ss) and PAH (GSTM1-null) may have an increased risk of developing bladder cancer. aromatic amines 101-116 N-acetyltransferase 2 Homo sapiens 118-122 8423501-4 1993 Cytochrome P4501A1, P4502E1 and N-acetyl transferase 2 are examples of enzymes involved in the metabolic activation of potential environmental carcinogens such as polycyclic aromatic hydrocarbons, benzene, and aromatic amines, respectively. aromatic amines 210-225 N-acetyltransferase 2 Homo sapiens 20-54 7585580-2 1995 The aromatic amines and their metabolites, a class of carcinogen implicated in these exposures, can be N- or O-acetylated by the NAT1 and NAT2 enzymes. aromatic amines 4-19 N-acetyltransferase 2 Homo sapiens 138-142 31254350-1 2019 OBJECTIVE: N-Acetyltransferase 2 (NAT2) is a phase II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines and aromatic amines. aromatic amines 145-160 N-acetyltransferase 2 Homo sapiens 11-32 32497306-2 2020 NAT2 has previously been classified as an arylamine N-acetyltransferase that mainly converts aromatic amines, hydroxylamines and hydrazines. aromatic amines 93-108 N-acetyltransferase 2 Homo sapiens 0-4 31332782-1 2019 BACKGROUND: N-acetyltransferase 2 (NAT2) is a key enzyme involved in the phase II metabolism of aromatic amines and heterocyclic aromatic amines present in a wide range of xenobiotics. aromatic amines 96-111 N-acetyltransferase 2 Homo sapiens 12-33 31332782-1 2019 BACKGROUND: N-acetyltransferase 2 (NAT2) is a key enzyme involved in the phase II metabolism of aromatic amines and heterocyclic aromatic amines present in a wide range of xenobiotics. aromatic amines 96-111 N-acetyltransferase 2 Homo sapiens 35-39 31254350-1 2019 OBJECTIVE: N-Acetyltransferase 2 (NAT2) is a phase II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines and aromatic amines. aromatic amines 145-160 N-acetyltransferase 2 Homo sapiens 34-38 26681036-1 2015 The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). aromatic amines 71-86 N-acetyltransferase 2 Homo sapiens 194-198 28403014-6 2018 NAT2 slow genotype carriers had an OR of 3.59 (95% CI: 2.62-4.93) for BC when exposed to aromatic amines and an OR of 2.07 (95% CI: 1.36-3.15) when exposed to PAHs. aromatic amines 89-104 N-acetyltransferase 2 Homo sapiens 0-4 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. aromatic amines 142-157 N-acetyltransferase 2 Homo sapiens 99-103 29505746-1 2018 N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. aromatic amines 165-180 N-acetyltransferase 2 Homo sapiens 0-21 29505746-1 2018 N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. aromatic amines 165-180 N-acetyltransferase 2 Homo sapiens 23-27 31292670-2 2019 Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and NAT2 is subjected to a common genetic polymorphism in human populations separating individuals into rapid, intermediate, and slow acetylator phenotypes. aromatic amines 78-93 N-acetyltransferase 2 Homo sapiens 42-46 31292670-2 2019 Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and NAT2 is subjected to a common genetic polymorphism in human populations separating individuals into rapid, intermediate, and slow acetylator phenotypes. aromatic amines 78-93 N-acetyltransferase 2 Homo sapiens 98-102