PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26950369-3 2016 We determined structures of hOX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution, respectively, and used molecular modeling to illuminate mechanisms of antagonist subtype selectivity between hOX1R and hOX2R. suvorexant 107-117 hypocretin receptor 1 Homo sapiens 28-33 26950369-3 2016 We determined structures of hOX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution, respectively, and used molecular modeling to illuminate mechanisms of antagonist subtype selectivity between hOX1R and hOX2R. suvorexant 107-117 hypocretin receptor 1 Homo sapiens 29-33 25291725-1 2014 Suvorexant is a pharmacologically novel dual antagonist of orexin receptors OX1R and OX2R, which has an effect that promotes sleep by reducing arousal and wakefulness. suvorexant 0-10 hypocretin receptor 1 Homo sapiens 76-80