PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22292957-4	2012	A 10 ns molecular dynamics simulation showed that one copper ion at the tyrosinase active site was responsible for the interaction with rutin.	Rutin	136-141	tyrosinase	Homo sapiens	72-82	
22292957-7	2012	Measurements of intrinsic and ANS-binding fluorescences showed that rutin showed a relatively strong binding affinity for tyrosinase and one possible binding site that could be a copper was detected accompanying with a hydrophobic exposure of tyrosinase.	Rutin	68-73	tyrosinase	Homo sapiens	122-132	
22292957-7	2012	Measurements of intrinsic and ANS-binding fluorescences showed that rutin showed a relatively strong binding affinity for tyrosinase and one possible binding site that could be a copper was detected accompanying with a hydrophobic exposure of tyrosinase.	Rutin	68-73	tyrosinase	Homo sapiens	243-253