PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26585763-3 2016 Quercetin-glycosides were recently shown to prevent thrombosis in animal models through the inhibition of extracellular protein disulfide isomerase (PDI). Rutin 0-20 prolyl 4-hydroxylase subunit beta Homo sapiens 120-147 35377153-2 2022 The finding that quercetin-3-rutinoside inhibits protein disulfide isomerase (PDI) and potently blocks thrombosis in vivo has enabled the evaluation of PDI inhibition in multiple animal models of thrombus formation and has prompted clinical studies of PDI inhibition in thrombosis. Rutin 17-39 prolyl 4-hydroxylase subunit beta Homo sapiens 49-76 35377153-2 2022 The finding that quercetin-3-rutinoside inhibits protein disulfide isomerase (PDI) and potently blocks thrombosis in vivo has enabled the evaluation of PDI inhibition in multiple animal models of thrombus formation and has prompted clinical studies of PDI inhibition in thrombosis. Rutin 17-39 prolyl 4-hydroxylase subunit beta Homo sapiens 78-81 35377153-3 2022 Nonetheless, how quercetin-3-rutinoside blocks PDI activity remains an unanswered question. Rutin 17-39 prolyl 4-hydroxylase subunit beta Homo sapiens 47-50 35377153-4 2022 Combining NMR spectroscopy, site-directed mutagenesis, and biological assays, we identified H256 as the key residue for PDI interacting with quercetin-3-rutinoside. Rutin 141-163 prolyl 4-hydroxylase subunit beta Homo sapiens 120-123 35377153-5 2022 Quercetin-3-rutinoside inhibited the activity of PDI (WT) but not PDI (H256A). Rutin 0-22 prolyl 4-hydroxylase subunit beta Homo sapiens 49-52 35377153-7 2022 Among several quercetin-3-rutinoside analogues tested, only compounds with a phenoxyl group at position 7 showed direct binding to PDI, further supporting our molecular model. Rutin 14-36 prolyl 4-hydroxylase subunit beta Homo sapiens 131-134 35377153-8 2022 Studies using purified coagulation factors showed that quercetin-3-rutinoside inhibited the augmenting effects of PDI (WT), but not PDI (H256A), on tissue factor (TF) activity. Rutin 55-77 prolyl 4-hydroxylase subunit beta Homo sapiens 114-117 35377153-10 2022 Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside. Rutin 92-114 prolyl 4-hydroxylase subunit beta Homo sapiens 147-150 35377153-10 2022 Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside. Rutin 154-176 prolyl 4-hydroxylase subunit beta Homo sapiens 48-51 35377153-10 2022 Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside. Rutin 154-176 prolyl 4-hydroxylase subunit beta Homo sapiens 147-150 31382673-0 2019 Quercetin-3-Rutinoside Blocks the Disassembly of Cholera Toxin by Protein Disulfide Isomerase. Rutin 0-22 prolyl 4-hydroxylase subunit beta Homo sapiens 66-93 31382673-2 2019 Quercetin-3-rutinoside (Q3R) blocks this activity, but its inhibitory mechanism against PDI is not fully understood. Rutin 0-22 prolyl 4-hydroxylase subunit beta Homo sapiens 88-91 26919268-9 2016 Quercetin-3-rutinoside, a flavonol highly abundant in common foods, inhibits PDI and blocks thrombus formation both in vitro and in vivo. Rutin 0-22 prolyl 4-hydroxylase subunit beta Homo sapiens 77-80 26585763-3 2016 Quercetin-glycosides were recently shown to prevent thrombosis in animal models through the inhibition of extracellular protein disulfide isomerase (PDI). Rutin 0-20 prolyl 4-hydroxylase subunit beta Homo sapiens 149-152 23315166-6 2013 Blockade of free thiols, an inhibitory monoclonal antibody to protein disulfide isomerase (PDI), and the small-molecule PDI antagonist quercetin-3-rutinoside prevented ATG-mediated TF activation, and C5 complement activation resulted in oxidation of cell surface PDI. Rutin 135-157 prolyl 4-hydroxylase subunit beta Homo sapiens 120-123 25700620-5 2015 RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin). Rutin 239-261 prolyl 4-hydroxylase subunit beta Homo sapiens 73-76 25700620-5 2015 RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin). Rutin 239-261 prolyl 4-hydroxylase subunit beta Homo sapiens 201-204 25700620-5 2015 RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin). Rutin 239-261 prolyl 4-hydroxylase subunit beta Homo sapiens 201-204 25700620-5 2015 RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin). Rutin 251-256 prolyl 4-hydroxylase subunit beta Homo sapiens 73-76 25700620-5 2015 RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin). Rutin 251-256 prolyl 4-hydroxylase subunit beta Homo sapiens 201-204 25700620-5 2015 RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin). Rutin 251-256 prolyl 4-hydroxylase subunit beta Homo sapiens 201-204 23541171-6 2013 A recent high-throughput screening identified the commonly ingested flavonoid, quercetin-3-rutinoside, as an inhibitor of PDI. Rutin 79-101 prolyl 4-hydroxylase subunit beta Homo sapiens 122-125 23315166-6 2013 Blockade of free thiols, an inhibitory monoclonal antibody to protein disulfide isomerase (PDI), and the small-molecule PDI antagonist quercetin-3-rutinoside prevented ATG-mediated TF activation, and C5 complement activation resulted in oxidation of cell surface PDI. Rutin 135-157 prolyl 4-hydroxylase subunit beta Homo sapiens 120-123 22565308-5 2012 A high-throughput screen identified quercetin-3-rutinoside as an inhibitor of PDI reductase activity in vitro. Rutin 36-58 prolyl 4-hydroxylase subunit beta Homo sapiens 78-81 22565308-6 2012 Inhibition of PDI was selective, as quercetin-3-rutinoside failed to inhibit the reductase activity of several other thiol isomerases found in the vasculature. Rutin 36-58 prolyl 4-hydroxylase subunit beta Homo sapiens 14-17 22565308-9 2012 Infusion of recombinant PDI reversed the antithrombotic effect of quercetin-3-rutinoside. Rutin 66-88 prolyl 4-hydroxylase subunit beta Homo sapiens 24-27