PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21222511-1 2011 According to the structural characteristics of isoliquiritigenin from Glycyrrhiza uralensis, a series of hydroxychalcones has been designed, synthesized and evaluated for their in vitro inhibitory activities of beta-secretase (BACE1). hydroxychalcones 105-121 beta-secretase 1 Homo sapiens 227-232