PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32218734-0	2020	Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice.	Fluoxetine	8-18	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	53-59	
33845072-7	2021	In this study, acute and chronic fluoxetine treatment differentially alters the expression of 5-HT2C and microRNA-34a in the dorsal raphe.	Fluoxetine	33-43	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	94-100	
33845072-10	2021	Our results demonstrate a new miR-34a-mediated regulatory mechanism of 5-HT2C expression in the dorsal raphe and implicate it in eliciting the behavioral responses to chronic fluoxetine treatment.	Fluoxetine	175-185	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	71-77	
32218734-9	2020	While fluoxetine did not change 5-HT and 5-HIAA levels, and its turnover in the PAG, it up-regulated 5HT1A and 5-HT2C receptors in this midbrain area.	Fluoxetine	6-16	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	111-117	
32218734-12	2020	These results suggest that (i) 5-HT may facilitate nociception and intensify OAA, acting at amygdala 5-HT1A and 5-HT2C receptors, respectively, and (ii) fluoxetine modulates the OAA through activation of 5-HT2C receptors within the PAG.	Fluoxetine	153-163	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	112-118	
32218734-12	2020	These results suggest that (i) 5-HT may facilitate nociception and intensify OAA, acting at amygdala 5-HT1A and 5-HT2C receptors, respectively, and (ii) fluoxetine modulates the OAA through activation of 5-HT2C receptors within the PAG.	Fluoxetine	153-163	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	204-210	
32218734-13	2020	These findings indicate that chronic fluoxetine impairs the effects of 5-HT1A and 5-HT2C receptors activation in the amygdala and PAG on fear-induced antinociception in mice.	Fluoxetine	37-47	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	82-88	
32218734-2	2020	Acute fluoxetine impairs 5-HT2C (but not 5-HT1A) receptor activation in the amygdaloid complex.	Fluoxetine	6-16	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	25-31	
32218734-3	2020	Given that fluoxetine produces its clinical therapeutic effects only when given chronically, this study investigated the effects of chronic treatment with fluoxetine on the effects produced by 5-HT1A or 5-HT2C receptors activation in the amygdala or PAG on fear-induced antinociception.	Fluoxetine	155-165	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	203-209	
27516377-4	2017	Notably, 5-HT medications, including fluoxetine, d-fenfluramine, and lorcaserin (a selective 5-HT2CR agonist), act on 5-HT2CRs expressed by DA neurons to inhibit binge-like eating in mice.	Fluoxetine	37-47	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	93-100	
29548885-0	2018	Activation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine.	Fluoxetine	153-163	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	14-20	
31968217-0	2020	Fluoxetine improves behavioural deficits induced by chronic alcohol treatment by alleviating RNA editing of 5-HT2C receptors.	Fluoxetine	0-10	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	108-114	
31968217-8	2020	Our study suggests that the astrocytic 5-HT2CR contribute to alcohol addiction; fluoxetine thus can be used to alleviate depression, treat alcohol addiction and improve motor coordination.	Fluoxetine	80-90	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	39-46	
28588509-8	2017	The effects of fluoxetine, but not of d-amphetamine, were prevented by the selective 5-HT2C receptor antagonist SB242084.	Fluoxetine	15-25	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	85-100	
25851944-2	2015	In contrast, neurones isolated from transgenic mice tagged with a neurone-specific marker and exposed to fluoxetine showed an increase in gene expression of glutamate receptor, ionotropic kainate 4 (GluK4) and 5-hydroxytryptamine receptor 2C (5-HT2CR).	Fluoxetine	105-115	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	243-250	
25851944-4	2015	OBJECTIVE: To investigate the effects of chronic mild stress (CMS) and/or fluoxetine treatment on gene expression of 5-HT2BR, 5-HT2CR, cPLA2alpha, ADAR2, GluK2 and GluK4 specifically in astrocytes and neurones.	Fluoxetine	74-84	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	126-133	
11988161-2	2002	Treatment of mice with fluoxetine alters the pattern of 5-HT2C transcript editing in the direction opposite that observed for suicide victims.	Fluoxetine	23-33	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	56-62	
20846463-5	2010	Paroxetine, which differs widely from fluoxetine in affinity for SERT and for another 5-HT2 receptor, the 5-HT2C receptor, acted acutely and chronically like fluoxetine.	Fluoxetine	158-168	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	106-121	
17287521-4	2007	However, when fluoxetine was administered during adolescence, depression-like behavioral responses to stress were significantly diminished in these mice, and their basal and stress-induced 5-HT2C pre-mRNA editing phenotypes were significantly lower.	Fluoxetine	14-24	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	189-195	
19662385-1	2009	INTRODUCTION: We have recently shown that fluoxetine, a serotonin-specific reuptake inhibitor (SSRI), has low micromolar affinity for the 5-HT(2C) receptor (but not for 5-HT(2A) and 5-HT(2B) receptors) in primary cultures of mouse astrocytes.	Fluoxetine	42-52	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	138-155	
15659601-5	2005	In contrast, exposure of BALB/c mice to acute stress and chronic treatment of nonstressed BALB/c mice with fluoxetine elicit significant, site-specific increases in 5-HT2C pre-mRNA editing that increase the pool of mRNA encoding receptors with reduced function.	Fluoxetine	107-117	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	165-171	
15659601-7	2005	However, when chronic fluoxetine treatment is combined with stress exposure of BALB/c mice, these changes in 5-HT2C pre-mRNA editing are no longer detected.	Fluoxetine	22-32	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	109-115	
15659601-8	2005	These findings illustrate that 5-HT2C pre-mRNA editing responses to stress and chronic fluoxetine are modulated by the genetic background, as well as the behavioral state of the animal.	Fluoxetine	87-97	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	31-37	
9888626-6	1998	This contrasts previous results obtained with fluoxetine, where was found that its stimulus is primarily mediated by 5-HT2C, and to a lesser degree by 5-HT1A receptors.	Fluoxetine	46-56	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	117-123	
9888626-9	1998	We conclude that 5-HT1A receptors are involved in the stimulus properties of both fluvoxamine and fluoxetine, that 5-HT2C receptors are involved in fluvoxamine and especially fluoxetine, and, based primarily on the cross-comparison tests, that the two SSRIs have somewhat different stimulus properties.	Fluoxetine	175-185	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	115-121	
8099969-6	1993	The results suggest that fluoxetine reduces immobility time in mice forced to swim, by acting indirectly through a mesulergine-sensitive site, probably the 5-HT1C receptor.	Fluoxetine	25-35	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	156-162