PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28465217-4	2017	This study evaluates the involvement of nine common antidepressants in the NLRP3-inflammasome complex (fluoxetine, paroxetine, mianserin, mirtazapine, venlafaxine, desvenlafaxine, amitriptyline, imipramine and agomelatine), both in in vitro THP-1 cells stimulated by ATP, and in a stress-induced depressive animal or MDD patients.	Fluoxetine	103-113	NLR family pyrin domain containing 3	Homo sapiens	75-80	
34620711-0	2021	Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration.	Fluoxetine	18-28	NLR family pyrin domain containing 3	Homo sapiens	41-46	
34620711-6	2021	We report that fluoxetine, an FDA-approved drug for treating clinical depression, binds NLRP3 in silico, in vitro, and in vivo and inhibits activation of the NLRP3-ASC inflammasome and inflammatory cytokine release in RPE cells and macrophages, two critical cell types in dry AMD.	Fluoxetine	15-25	NLR family pyrin domain containing 3	Homo sapiens	88-93	
34620711-6	2021	We report that fluoxetine, an FDA-approved drug for treating clinical depression, binds NLRP3 in silico, in vitro, and in vivo and inhibits activation of the NLRP3-ASC inflammasome and inflammatory cytokine release in RPE cells and macrophages, two critical cell types in dry AMD.	Fluoxetine	15-25	NLR family pyrin domain containing 3	Homo sapiens	158-163	
30666218-8	2018	In this study, we discovered: (i) that activation of NLRP3 inflammasome was involved in the depressive-like behaviors induced by SD; (ii) decrease in BDNF following SD required the activation of NLRP3 inflammasomes; (iii) leptin augmented the anti-depressive action of fluoxetine through an increase in expression of astrocytic 5-HT2B receptors.	Fluoxetine	269-279	NLR family pyrin domain containing 3	Homo sapiens	53-58	
30666218-8	2018	In this study, we discovered: (i) that activation of NLRP3 inflammasome was involved in the depressive-like behaviors induced by SD; (ii) decrease in BDNF following SD required the activation of NLRP3 inflammasomes; (iii) leptin augmented the anti-depressive action of fluoxetine through an increase in expression of astrocytic 5-HT2B receptors.	Fluoxetine	269-279	NLR family pyrin domain containing 3	Homo sapiens	195-200