PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12787062-5 2003 TH gene transcription rate increased from four- to eight-fold in control cells after treatment with either 50 mM KCl or TPA. Potassium Chloride 113-116 tyrosine hydroxylase Rattus norvegicus 0-2 18258664-3 2008 Depolarization induced either by 40 mm KCl, veratridine or by electrical field stimulation produced a robust and significant increase in the proportion of TH immunoreactive (TH-IR) neurons (total neuronal population was identified with PGP9.5 or Hu) compared to control. Potassium Chloride 39-42 tyrosine hydroxylase Rattus norvegicus 155-157 18258664-3 2008 Depolarization induced either by 40 mm KCl, veratridine or by electrical field stimulation produced a robust and significant increase in the proportion of TH immunoreactive (TH-IR) neurons (total neuronal population was identified with PGP9.5 or Hu) compared to control. Potassium Chloride 39-42 tyrosine hydroxylase Rattus norvegicus 174-176 18258664-6 2008 The KCl-induced increase in TH expression was partly reduced in the presence of the nicotinic receptor antagonist hexamethonium (100 microm), of noradrenaline (1 microm) and of the alpha(2)-adrenoreceptor agonist clonidine (1 microm). Potassium Chloride 4-7 tyrosine hydroxylase Rattus norvegicus 28-30 18258664-7 2008 Combining pharmacological and calcium imaging studies, we have further shown that L-type calcium channels were involved in the increase of TH expression induced by KCl. Potassium Chloride 164-167 tyrosine hydroxylase Rattus norvegicus 139-141 12787062-8 2003 Stimulation of TH gene promoter activity, which was observed in control cell lines treated with either 50 mm KCl or TPA was also dramatically inhibited in the c-Fos-deficient cells. Potassium Chloride 109-112 tyrosine hydroxylase Rattus norvegicus 15-17 1662507-10 1991 Further, the tyrosine hydroxylase (TH) phosphorylation induced by KCl or acetylcholine was significantly suppressed by KN-93 in PC12h cells while events induced by forskolin or 8-Br-cAMP were not affected. Potassium Chloride 66-69 tyrosine hydroxylase Rattus norvegicus 13-33 9038229-2 1997 Membrane depolarization of PC12 cells using 50 mM KCl leads to induction of tyrosine hydroxylase (TH) mRNA. Potassium Chloride 50-53 tyrosine hydroxylase Rattus norvegicus 76-96 9038229-2 1997 Membrane depolarization of PC12 cells using 50 mM KCl leads to induction of tyrosine hydroxylase (TH) mRNA. Potassium Chloride 50-53 tyrosine hydroxylase Rattus norvegicus 98-100 8742459-2 1995 Although dopaminergic traits are normally detectable in only 10-20% of ganglion neurones, exposure to depolarizing concentrations of potassium chloride (40 mM) or veratridine (10 microM) in culture induced tyrosine hydroxylase expression in 100% of petrosal neurons and a 10-fold increase in dopamine content. Potassium Chloride 133-151 tyrosine hydroxylase Rattus norvegicus 206-226 1662507-10 1991 Further, the tyrosine hydroxylase (TH) phosphorylation induced by KCl or acetylcholine was significantly suppressed by KN-93 in PC12h cells while events induced by forskolin or 8-Br-cAMP were not affected. Potassium Chloride 66-69 tyrosine hydroxylase Rattus norvegicus 35-37 1686923-2 1991 In this study, the effect of elevated KCl, under isotonic and hypertonic conditions, on the changes in mRNA levels of the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was compared. Potassium Chloride 38-41 tyrosine hydroxylase Rattus norvegicus 158-178 1686923-2 1991 In this study, the effect of elevated KCl, under isotonic and hypertonic conditions, on the changes in mRNA levels of the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was compared. Potassium Chloride 38-41 tyrosine hydroxylase Rattus norvegicus 180-182 1686923-3 1991 Treatment of PC12 pheochromocytoma cells for several hours with 50 mM KCl, under conditions where osmolarity was maintained, induced TH mRNA levels several fold, without changing DBH mRNA levels (Kilbourne and Sabban, 1990). Potassium Chloride 70-73 tyrosine hydroxylase Rattus norvegicus 133-135 1686923-4 1991 In contrast, 50 mM KCl added to culture media without adjusting the osmolarity did not alter TH mRNA levels for up to 24 h. Longer continuous exposure to this hypertonic depolarization condition reduced TH mRNA levels to about 10% of control levels. Potassium Chloride 19-22 tyrosine hydroxylase Rattus norvegicus 203-205 1686923-10 1991 The extent of elevation of TH mRNA with isotonic KCl was also dependent on cell density. Potassium Chloride 49-52 tyrosine hydroxylase Rattus norvegicus 27-29 1979980-0 1990 Site-specific phosphorylation of tyrosine hydroxylase after KCl depolarization and nerve growth factor treatment of PC12 cells. Potassium Chloride 60-63 tyrosine hydroxylase Rattus norvegicus 33-53 1979980-1 1990 The phosphorylation and activation of tyrosine hydroxylase was examined in PC12 cells following depolarization with KCl or treatment with nerve growth factor. Potassium Chloride 116-119 tyrosine hydroxylase Rattus norvegicus 38-58 1979980-8 1990 We conclude that serine 31 is phosphorylated during KCl depolarization and nerve growth factor treatment of PC12 cells and that this phosphorylation is responsible for the activation of tyrosine hydroxylase. Potassium Chloride 52-55 tyrosine hydroxylase Rattus norvegicus 186-206 1976198-3 1990 TH mRNA levels were found to increase 2- to 5-fold after continuous treatment for 1-12 h with 50 mM KCl. Potassium Chloride 100-103 tyrosine hydroxylase Rattus norvegicus 0-2 2879754-6 1987 On the other hand, a culture medium supplemented with 40 mM KCl caused a 1.5- to 5-fold increase in TH activity, which was accompanied by an increase in TH-mRNA level of the same order of magnitude. Potassium Chloride 60-63 tyrosine hydroxylase Rattus norvegicus 100-102 2879754-6 1987 On the other hand, a culture medium supplemented with 40 mM KCl caused a 1.5- to 5-fold increase in TH activity, which was accompanied by an increase in TH-mRNA level of the same order of magnitude. Potassium Chloride 60-63 tyrosine hydroxylase Rattus norvegicus 153-155