PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32317146-5 2021 In this study, we evaluated the effect of the MCP-1 synthesis inhibitor, Bindarit, on primary cultures of fibroblasts from the SSCT of five CTS patients. bindarit 73-81 C-C motif chemokine ligand 2 Homo sapiens 46-51 33070717-10 2021 Decoupling the interaction between mobilized neutrophils/T cells and the neurovascular unit, achieved via a sphingosine-1-phosphate receptor 1 modulator RP101075 and a CCL2 synthesis inhibitor bindarit, which block lymphocyte egress and myeloid cell recruitment, respectively, attenuates hemorrhagic transformation and improves neurological function after tPA thrombolysis. bindarit 193-201 C-C motif chemokine ligand 2 Homo sapiens 168-172 29234825-2 2018 Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 12-16 32717406-7 2020 Furthermore, both minocycline and bindarit, a CCL-2 inhibitor, prevented apoptosis and electrophysiological dysfunction of Purkinje cells, the principal neurons and sole outputs of the cerebellar cortex, and consequently improved ataxia-like motor abnormalities. bindarit 34-42 C-C motif chemokine ligand 2 Homo sapiens 46-51 32678310-0 2021 Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties. bindarit 22-30 C-C motif chemokine ligand 2 Homo sapiens 14-18 32678310-4 2021 Moreover, inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal inflammation. bindarit 55-63 C-C motif chemokine ligand 2 Homo sapiens 24-28 26690313-1 2016 AIMS: Bindarit (BND) is a selective inhibitor of monocyte chemotactic protein-1 (MCP-1/CCL2), which plays an important role in generating intimal hyperplasia. bindarit 6-14 C-C motif chemokine ligand 2 Homo sapiens 49-79 26690313-1 2016 AIMS: Bindarit (BND) is a selective inhibitor of monocyte chemotactic protein-1 (MCP-1/CCL2), which plays an important role in generating intimal hyperplasia. bindarit 6-14 C-C motif chemokine ligand 2 Homo sapiens 81-86 26690313-1 2016 AIMS: Bindarit (BND) is a selective inhibitor of monocyte chemotactic protein-1 (MCP-1/CCL2), which plays an important role in generating intimal hyperplasia. bindarit 6-14 C-C motif chemokine ligand 2 Homo sapiens 87-91 27309675-12 2016 Our data strengthen the importance of CCL2 on ET-1, AngII- and TGFbeta-induced mesangial cell dysfunction, adding new insights into the cellular mechanisms responsible of bindarit protective effects in human MC dysfunction. bindarit 171-179 C-C motif chemokine ligand 2 Homo sapiens 38-42 22982961-2 2012 Bindarit is an original indazolic derivative able to inhibit MCPs synthesis and to significantly decrease MCP-1/CCL2 urinary excretion in patients with Lupus Nephritis, in correlation with reduction in albuminuria. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 106-111 22982961-2 2012 Bindarit is an original indazolic derivative able to inhibit MCPs synthesis and to significantly decrease MCP-1/CCL2 urinary excretion in patients with Lupus Nephritis, in correlation with reduction in albuminuria. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 112-116 22982961-5 2012 Bindarit (10-300 muM) significantly inhibited MCP-1/CCL2 release in response to both stimuli within 12h. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 46-51 22982961-5 2012 Bindarit (10-300 muM) significantly inhibited MCP-1/CCL2 release in response to both stimuli within 12h. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 52-56 22982961-6 2012 Bindarit also inhibited mRNA MCP-1/CCL2 expression, confirming an effect of the drug at transcriptional level. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 29-34 22982961-6 2012 Bindarit also inhibited mRNA MCP-1/CCL2 expression, confirming an effect of the drug at transcriptional level. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 35-39 27069537-18 2016 Such phenomenon was completely reversed after administration of MCP-1 inhibitor (Bindarit). bindarit 81-89 C-C motif chemokine ligand 2 Homo sapiens 64-69 23948942-0 2014 Bindarit, inhibitor of CCL2 synthesis, protects neurons against amyloid-beta-induced toxicity. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 23-27 23948942-6 2014 In the present study, we demonstrated the protective effect of bindarit (which inhibits CCL2 synthesis) against both Abeta25-35 and Abeta1-42-induced toxicity in primary mixed neural cultures. bindarit 63-71 C-C motif chemokine ligand 2 Homo sapiens 88-92 23948942-7 2014 Bindarit (30-500 muM) reversed cell death induced by Abeta in a dose-dependent manner and reduced the transcription and release of CCL2 by astrocytes after Abeta treatment, as revealed by qRT-PCR, ELISA, and immunofluorescence staining. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 131-135 18775807-4 2008 Here we comprehensively examine the effect of bindarit on the chemokine system, and report that in activated monocytes and endothelial cells, it selectively inhibits the production of the monocyte chemotactic protein subfamily of CC inflammatory chemokines (MCP-1/CCL2, MCP-3/CCL7, MCP-2/CCL8). bindarit 46-54 C-C motif chemokine ligand 2 Homo sapiens 258-263 18827968-2 2008 We investigated the ability of bindarit, an inhibitor of monocyte chemoattractant protein-1 (MCP-1/CCL2) synthesis, to inhibit chemokine production by human intestinal epithelial cells (HT-29) and its effect in trinitro-benzene sulfonic acid (TNBS)-induced colitis in mice. bindarit 31-39 C-C motif chemokine ligand 2 Homo sapiens 57-91 18827968-2 2008 We investigated the ability of bindarit, an inhibitor of monocyte chemoattractant protein-1 (MCP-1/CCL2) synthesis, to inhibit chemokine production by human intestinal epithelial cells (HT-29) and its effect in trinitro-benzene sulfonic acid (TNBS)-induced colitis in mice. bindarit 31-39 C-C motif chemokine ligand 2 Homo sapiens 93-98 18827968-2 2008 We investigated the ability of bindarit, an inhibitor of monocyte chemoattractant protein-1 (MCP-1/CCL2) synthesis, to inhibit chemokine production by human intestinal epithelial cells (HT-29) and its effect in trinitro-benzene sulfonic acid (TNBS)-induced colitis in mice. bindarit 31-39 C-C motif chemokine ligand 2 Homo sapiens 99-103 18827968-6 2008 RESULTS: In HT-29 cells, bindarit concentration-dependently and selectively inhibited MCP-1 secretion (as well as mRNA expression) primed by TNF-alpha/IFN-gamma. bindarit 25-33 C-C motif chemokine ligand 2 Homo sapiens 86-91 21876349-5 2011 RESULTS: Urinary CCL2 significantly decreased during bindarit therapy (p = 0.008 vs. baseline) with a reduction that approximated 50% at study end. bindarit 53-61 C-C motif chemokine ligand 2 Homo sapiens 17-21 18775807-4 2008 Here we comprehensively examine the effect of bindarit on the chemokine system, and report that in activated monocytes and endothelial cells, it selectively inhibits the production of the monocyte chemotactic protein subfamily of CC inflammatory chemokines (MCP-1/CCL2, MCP-3/CCL7, MCP-2/CCL8). bindarit 46-54 C-C motif chemokine ligand 2 Homo sapiens 264-268