PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35358511-7	2022	We show that blocking Ddi2"s endoprotease activity either genetically or with the HIV protease inhibitor nelfinavir increased its binding to ubiquitin conjugates, but decreased its binding to proteasomes, and reduced subsequent protein degradation by proteasomes leading to further accumulation of ubiquitin conjugates.	Nelfinavir	105-115	cyanamide hydratase	Saccharomyces cerevisiae S288C	22-26	
35358511-8	2022	Finally, nelfinavir treatment required Ddi2 to induce the unfolded protein response.	Nelfinavir	9-19	cyanamide hydratase	Saccharomyces cerevisiae S288C	39-43