PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27121513-8 2016 This review describes the mechanisms by which PI3-K/AKT pathway causes radioresistance and the role of HIV protease inhibitors especially nelfinavir as a potential candidate drug to target the AKT pathway for overcoming radioresistance and its use in various clinical trials for different malignancies. Nelfinavir 138-148 AKT serine/threonine kinase 1 Rattus norvegicus 193-196 15269981-5 2004 RESULT: Nelfinavir decreased insulin stimulated phosphorylation of IRS-2 and Akt-Thr(308) in a dose-dependent manner; for 10 micromol/L of nelfinavir, the decrease was 52% and 55%, respectively. Nelfinavir 8-18 AKT serine/threonine kinase 1 Rattus norvegicus 77-80 15269981-5 2004 RESULT: Nelfinavir decreased insulin stimulated phosphorylation of IRS-2 and Akt-Thr(308) in a dose-dependent manner; for 10 micromol/L of nelfinavir, the decrease was 52% and 55%, respectively. Nelfinavir 139-149 AKT serine/threonine kinase 1 Rattus norvegicus 77-80