PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8620667-0	1995	The pharmacokinetic and pharmacodynamic interactions between the 5-lipoxygenase inhibitor zileuton and the cyclo-oxygenase inhibitor naproxen in human volunteers.	Naproxen	133-141	arachidonate 5-lipoxygenase	Homo sapiens	65-79	
9057869-1	1997	Representative nonsteroidal anti-inflammatory drug (NSAID) cyclooxygenase inhibitors such as ibuprofen, naproxen, and indomethacin were used as orally bioavailable scaffolds to design selective 5-lipoxygenase (5-LO) inhibitors.	Naproxen	104-112	arachidonate 5-lipoxygenase	Homo sapiens	194-208	
9061203-1	1997	Representative examples of NSAID cyclooxygenase inhibitors such as naproxen, ibufenac, ibuprofen, and butibufen have been transformed into 5-lipoxygenase inhibitors by replacement of the carboxylic acid moiety with a 4-hydroxythiazole group.	Naproxen	67-75	arachidonate 5-lipoxygenase	Homo sapiens	139-153	
25091567-0	2015	Naproxen induces type X collagen expression in human bone-marrow-derived mesenchymal stem cells through the upregulation of 5-lipoxygenase.	Naproxen	0-8	arachidonate 5-lipoxygenase	Homo sapiens	124-138	
25091567-11	2015	To investigate the involvement of these pathways in the Naproxen-induced COL10A1 expression, we incubated normal and OA hMSCs with Naproxen with and without inhibitors of ERK (U0126), JNK (BI-78D3), p38 (SB203580), and 5-lipoxygenase (MK-886).	Naproxen	56-64	arachidonate 5-lipoxygenase	Homo sapiens	219-233	
25091567-12	2015	Our results showed that increased basal COL10A1 expression in OA hMSCs was significantly suppressed in the presence of JNK and p38 inhibitors, whereas Naproxen-induced COL10A1 expression was suppressed by 5-lipoxygenase inhibitor.	Naproxen	151-159	arachidonate 5-lipoxygenase	Homo sapiens	205-219	
25091567-14	2015	Elevated basal COL10A1 expression in OA hMSCs is probably through the activation of MAPK pathway and Naproxen-induced COL10A1 expression is through the increased 5-lipoxygenase signaling.	Naproxen	101-109	arachidonate 5-lipoxygenase	Homo sapiens	162-176