PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35469044-5	2022	In human adipose arterioles (HAA), ACh-induced dilation was significantly reduced by TRPV4 inhibitor HC067047 and by NOX 1/4 inhibitor GKT137831, but GKT137831 did not further affect the dilation in the presence of TRPV4 inhibitors.	setanaxib	135-144	transient receptor potential cation channel subfamily V member 4	Homo sapiens	215-220	
35469044-6	2022	GKT137831 also inhibited TRPV4 agonist GSK1016790A-induced dilation in HAA and human coronary arterioles (HCA).	setanaxib	0-9	transient receptor potential cation channel subfamily V member 4	Homo sapiens	25-30	
35469044-8	2022	Using fura-2 imaging, GKT137831 significantly reduced GSK1016790A-induced Ca2+ influx in the primary culture of endothelial cells and TRPV4-WT-overexpressing human coronary artery endothelial cells (HCAEC).	setanaxib	22-31	transient receptor potential cation channel subfamily V member 4	Homo sapiens	134-139	
35469044-10	2022	In addition, treatment of HCAEC with GKT137831 decreased the phosphorylation level of Ser824 in TRPV4.	setanaxib	37-46	transient receptor potential cation channel subfamily V member 4	Homo sapiens	96-101