PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10696460-2 2000 STUDY DESIGN: We analyzed the differential expression of different apoptosis modulators, Bcl-2, Bax, p53 and Fas, for their potential role in PB-induced apoptosis using relative quantitative flow cytometry (FCM). Phenylbutyrates 142-144 BCL2 apoptosis regulator Homo sapiens 89-94 10696460-7 2000 FCM revealed a heterogeneous stimulatory effect on the expression of Bax and Bcl-2 in PC3-PF cells at 0.5-2.5 mM PB. Phenylbutyrates 113-115 BCL2 apoptosis regulator Homo sapiens 77-82 10696460-9 2000 CONCLUSION: Our data show that PB-induced PCa apoptosis is associated with the relative repression of Bcl-2 and with up-regulation of Bax and Fas proteins and that this PB-induced apoptosis is independent of p53 and androgen-dependency status of PCa cell lines. Phenylbutyrates 31-33 BCL2 apoptosis regulator Homo sapiens 102-107