PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32662411-8 2021 The in vivo experiments disclosed that iguratimod reduced systemic arthritis score, and decreased TNF-alpha, IL-1beta, IL-6, IL-17, IRAK1 as well as TRAF6/JNK1 pathway, while enhanced apoptosis in synovial tissue of CIA rat model; and in miR-146a inhibition treated CIA rat model, the effect of iguratimod was diminished. iguratimod 39-49 interleukin 1 alpha Rattus norvegicus 109-117