PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28578001-5 2017 By searching for a signal transduction pathway involved in 1,25(OH)2D3-induced expression of TRPV6, we found that a p38 mitogen-activated protein kinase (MAPK) inhibitor reduces the expression of TRPV6 but not CYP24A1 in 1,25(OH)2D3-treated SW480 cells. Calcitriol 59-70 mitogen-activated protein kinase 14 Homo sapiens 116-119 32896986-11 2021 Combination of genistein and calcitriol reduced HOs-induced TonEBP, inflammatory gene expression, and p-p38, and abated VDR degradation in HCECs. Calcitriol 29-39 mitogen-activated protein kinase 14 Homo sapiens 104-107 30430362-0 2019 1,25-Dihydroxy Vitamin D3 Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM2.5via the p38/NF-kappaB/NLRP3 Pathway. Calcitriol 0-25 mitogen-activated protein kinase 14 Homo sapiens 104-107 30961684-5 2019 Blocking p38 signaling attenuated the inhibitory effect of 1,25(OH)2D3 on the upregulation of COX-2 and phosphorylation of p38. Calcitriol 59-70 mitogen-activated protein kinase 14 Homo sapiens 9-12 30961684-5 2019 Blocking p38 signaling attenuated the inhibitory effect of 1,25(OH)2D3 on the upregulation of COX-2 and phosphorylation of p38. Calcitriol 59-70 mitogen-activated protein kinase 14 Homo sapiens 123-126 30593206-0 2018 1,25-dihydroxyvitamin-D3 promotes neutrophil apoptosis in periodontitis with type 2 diabetes mellitus patients via the p38/MAPK pathway. Calcitriol 0-24 mitogen-activated protein kinase 14 Homo sapiens 119-122 28578001-0 2017 1alpha,25-Dihydroxyvitamin D3 enhances TRPV6 transcription through p38 MAPK activation and GADD45 expression. Calcitriol 0-29 mitogen-activated protein kinase 14 Homo sapiens 67-70 28578001-5 2017 By searching for a signal transduction pathway involved in 1,25(OH)2D3-induced expression of TRPV6, we found that a p38 mitogen-activated protein kinase (MAPK) inhibitor reduces the expression of TRPV6 but not CYP24A1 in 1,25(OH)2D3-treated SW480 cells. Calcitriol 221-232 mitogen-activated protein kinase 14 Homo sapiens 116-119 28578001-6 2017 Knockdown experiments showed that p38alpha is involved in 1,25(OH)2D3-induced expression of TRPV6 but not CYP24A1. Calcitriol 58-69 mitogen-activated protein kinase 14 Homo sapiens 34-42 20936945-3 2011 Calcitriol also exhibits several anti-inflammatory effects including suppression of prostaglandin (PG) action, inhibition of p38 stress kinase signaling, and the subsequent production of pro-inflammatory cytokines and inhibition of NF-kappaB signaling. Calcitriol 0-10 mitogen-activated protein kinase 14 Homo sapiens 125-128 25905635-0 2015 1alpha,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients. Calcitriol 0-29 mitogen-activated protein kinase 14 Homo sapiens 71-74 23847446-0 2013 1,25-Dihydroxyvitamin D3 activates MMP13 gene expression in chondrocytes through p38 MARK pathway. Calcitriol 0-24 mitogen-activated protein kinase 14 Homo sapiens 81-84 23847446-9 2013 Interestingly, a specific mitogen-activated protein kinase p38 inhibitor SB203580, but not JNK kinase inhibitor SP600125, abrogated 1,25-(OH)2D3 activation of MMP13 expression. Calcitriol 132-144 mitogen-activated protein kinase 14 Homo sapiens 59-62 23847446-10 2013 1,25-(OH)2D3-induced increase in MMP13 protein level was in parallel with the phosphorylation of p38 in chondrocytes. Calcitriol 0-12 mitogen-activated protein kinase 14 Homo sapiens 97-100 23847446-14 2013 Taken together, we provide the first evidence to demonstrate that 1,25-(OH)2D3 activates MMP13 expression through p38 pathway in chondrocytes. Calcitriol 66-78 mitogen-activated protein kinase 14 Homo sapiens 114-117 19624893-9 2009 The 1,25(OH)2D3-induced apoptosis of Hep-2 cells was partly blocked by p38 inhibitor SB2035080. Calcitriol 4-15 mitogen-activated protein kinase 14 Homo sapiens 71-74 19415458-0 2009 5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway. Calcitriol 37-66 mitogen-activated protein kinase 14 Homo sapiens 115-118 19926709-5 2010 Second, calcitriol increases the expression of mitogen-activated protein kinase phosphatase 5 in prostate cells resulting in the subsequent inhibition of p38 stress kinase signaling and the attenuation of the production of pro-inflammatory cytokines. Calcitriol 8-18 mitogen-activated protein kinase 14 Homo sapiens 154-157 18717824-11 2008 CONCLUSIONS: The decreased NFkappaB and p38 activities followed by calcitriol treatment may explain the anti-inflammatory/atherosclerotic properties of calcitriol that were observed previously and were emphasized in this study, demonstrating the inhibitory effect of calcitriol on the pro-inflammatory parameters: adhesion molecules, RAGE and IL-6. Calcitriol 152-162 mitogen-activated protein kinase 14 Homo sapiens 40-43 18717824-0 2008 Calcitriol blunts pro-atherosclerotic parameters through NFkappaB and p38 in vitro. Calcitriol 0-10 mitogen-activated protein kinase 14 Homo sapiens 70-73 18717824-10 2008 The increased levels of activated p38 MAPK after LPS treatment were also decreased due to pre-incubation with calcitriol. Calcitriol 110-120 mitogen-activated protein kinase 14 Homo sapiens 34-37 18717824-11 2008 CONCLUSIONS: The decreased NFkappaB and p38 activities followed by calcitriol treatment may explain the anti-inflammatory/atherosclerotic properties of calcitriol that were observed previously and were emphasized in this study, demonstrating the inhibitory effect of calcitriol on the pro-inflammatory parameters: adhesion molecules, RAGE and IL-6. Calcitriol 152-162 mitogen-activated protein kinase 14 Homo sapiens 40-43 10896794-0 2000 Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells. Calcitriol 96-122 mitogen-activated protein kinase 14 Homo sapiens 14-17 18077140-12 2008 1 alpha,25(OH)2D3 also triggered the phosphorylation of p38, which contributes to involucrin induction. Calcitriol 0-17 mitogen-activated protein kinase 14 Homo sapiens 56-59 18077140-13 2008 Moreover, dn-PPAR gamma prevented the 1 alpha,25(OH)2D3-induced phosphorylation of p38. Calcitriol 38-55 mitogen-activated protein kinase 14 Homo sapiens 83-86 17229571-8 2007 Calcitriol induces MKP5 expression in prostate cells leading to the selective dephosphorylation and inactivation of the stress-activated kinase p38. Calcitriol 0-10 mitogen-activated protein kinase 14 Homo sapiens 144-147 17229571-9 2007 Since p38 activation is pro-carcinogenic and is a mediator of inflammation, this calcitriol action, especially coupled with the inhibition of the PG pathway, contributes to the chemopreventive activity of calcitriol in PCa. Calcitriol 205-215 mitogen-activated protein kinase 14 Homo sapiens 6-9 16598785-4 2006 1,25-Dihydroxyvitamin D3 and TGF-beta stimulated phosphorylation of p38 MAP kinase in an additive manner. Calcitriol 0-24 mitogen-activated protein kinase 14 Homo sapiens 68-82 16598785-5 2006 SB203580, an inhibitor of p38 MAP kinase, decreased the VEGF release induced by TGF-beta or 1,25-dihydroxyvitamin D3. Calcitriol 92-116 mitogen-activated protein kinase 14 Homo sapiens 26-29 16598785-8 2006 The stimulatory effect of 1,25-dihydroxyvitamin D3 occurs, in part, via modification of TGF-beta-induced activation of p38 MAP kinase. Calcitriol 26-50 mitogen-activated protein kinase 14 Homo sapiens 119-133 16532377-9 2006 1,25(OH)2D3 inhibited the stress-induced activation of p38 and JNK. Calcitriol 0-11 mitogen-activated protein kinase 14 Homo sapiens 55-58 15225801-7 2004 Taken together, these findings suggest that p38 MAP kinase plays an anti-apoptotic role in TNF-alpha-induced cytotoxicity in MCF-7 cells and that the synergistic interaction between TNF-alpha and calcitriol, leading to mitochondrial damage and subsequent cell death, is partially due to modulation of this signaling pathway. Calcitriol 196-206 mitogen-activated protein kinase 14 Homo sapiens 44-47 11811942-0 2002 1,25-dihydroxyvitamin D3 stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of p38 mitogen-activated protein kinase. Calcitriol 0-24 mitogen-activated protein kinase 14 Homo sapiens 118-154 18290727-6 2007 Acting on a separate anti-inflammatory pathway, calcitriol induces the expression of mitogen-activated protein kinase phosphatase 5 (MKP5), a member of a family of phosphatases that are negative regulators of MAP kinases, causing the selective dephosphorylation and inactivation of the stress-activated protein kinase p38. Calcitriol 48-58 mitogen-activated protein kinase 14 Homo sapiens 318-321 18290727-7 2007 Because p38 activation may be both procarcinogenic and promote inflammation, this calcitriol action, especially coupled with the inhibition of the PG pathway, may contribute to the chemopreventive activity of calcitriol. Calcitriol 209-219 mitogen-activated protein kinase 14 Homo sapiens 8-11 15225801-0 2004 The role of p38 MAP kinase in the synergistic cytotoxic action of calcitriol and TNF-alpha in human breast cancer cells. Calcitriol 66-76 mitogen-activated protein kinase 14 Homo sapiens 12-15 12174089-9 2002 1,25(OH)2D3 may induce apoptosis either indirectly through effects on the insulin-like growth receptor and tumour necrosis factor-alpha or more directly via the Bcl-2 family system, the ceramide pathway, the death receptors (e.g. Fas) and the stress-activated protein kinase pathways (Jun N terminal kinase and p38). Calcitriol 0-11 mitogen-activated protein kinase 14 Homo sapiens 311-314