PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11710940-2	2001	Phospholipase C-gamma1 is the most abundant member of the phospholipase C family in keratinocytes and is induced by 1,25-dihydroxyvitamin D3.	Calcitriol	116-140	phospholipase C gamma 1	Homo sapiens	0-22	
11710940-3	2001	Therefore, phospholipase C-gamma1 might be important in the signaling pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differentiation.	Calcitriol	88-112	phospholipase C gamma 1	Homo sapiens	11-33	
11710940-4	2001	To test this hypothesis, phospholipase C-gamma1 expression in human keratinocytes was reduced by transfecting the cells with an antisense phospholipase C-gamma1 construct and then evaluating the response of the keratinocyte differentiation markers involucrin and transglutaminase to 1,25-dihydroxyvitamin D3.	Calcitriol	283-307	phospholipase C gamma 1	Homo sapiens	25-47	
11710940-6	2001	Cotransfection of keratinocytes with the involucrin or transglutaminase promoter construct and the antisense phospholipase C-gamma1 construct showed decreased involucrin or transglutaminase promoter activity in response to 1,25-dihydroxyvitamin D3.	Calcitriol	223-247	phospholipase C gamma 1	Homo sapiens	109-131	
11710940-8	2001	The increase in keratinocyte intracellular free calcium and inositol triphosphate levels following 1,25-dihydroxyvitamin D3 administration were markedly reduced by the transfection of the antisense phospholipase C-gamma1 construct.	Calcitriol	99-123	phospholipase C gamma 1	Homo sapiens	198-220	
11710940-9	2001	These studies indicate that phospholipase C-gamma1 plays a critical role in the signal transduction pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differentiation at least in part by mediating the increase in inositol triphosphate production and intracellular calcium mobilization following 1,25-dihydroxyvitamin D3 administration.	Calcitriol	118-142	phospholipase C gamma 1	Homo sapiens	28-50	
11710940-9	2001	These studies indicate that phospholipase C-gamma1 plays a critical role in the signal transduction pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differentiation at least in part by mediating the increase in inositol triphosphate production and intracellular calcium mobilization following 1,25-dihydroxyvitamin D3 administration.	Calcitriol	308-332	phospholipase C gamma 1	Homo sapiens	28-50	
9579536-2	1998	Previous studies from our laboratory showed that phospholipase C-gamma1 (PLC-gamma1) was upregulated transcriptionally by 1,25(OH)2D3 in normal human keratinocytes, and a vitamin D responsive element (VDRE) in its promoter region has been identified.	Calcitriol	122-133	phospholipase C gamma 1	Homo sapiens	49-71	
9579536-2	1998	Previous studies from our laboratory showed that phospholipase C-gamma1 (PLC-gamma1) was upregulated transcriptionally by 1,25(OH)2D3 in normal human keratinocytes, and a vitamin D responsive element (VDRE) in its promoter region has been identified.	Calcitriol	122-133	phospholipase C gamma 1	Homo sapiens	73-83	
9579536-4	1998	The induction of the human PLC-gamma1 VDRE by 1,25(OH)2D3 was synergistic with all-trans retinoic acid in normal human keratinocytes, but none of the constructs was induced by 1,25(OH)2D3 and/or all-trans retinoic acid in SCC4 and SCC12B2 cells.	Calcitriol	46-57	phospholipase C gamma 1	Homo sapiens	27-37	
28926770-0	2017	1,25(OH)2D3 induces regulatory T cell differentiation by influencing the VDR/PLC-gamma1/TGF-beta1/pathway.	Calcitriol	0-11	phospholipase C gamma 1	Homo sapiens	77-87