PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28926770-0 2017 1,25(OH)2D3 induces regulatory T cell differentiation by influencing the VDR/PLC-gamma1/TGF-beta1/pathway. Calcitriol 0-11 phospholipase C gamma 1 Homo sapiens 77-87 11710940-2 2001 Phospholipase C-gamma1 is the most abundant member of the phospholipase C family in keratinocytes and is induced by 1,25-dihydroxyvitamin D3. Calcitriol 116-140 phospholipase C gamma 1 Homo sapiens 0-22 11710940-3 2001 Therefore, phospholipase C-gamma1 might be important in the signaling pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differentiation. Calcitriol 88-112 phospholipase C gamma 1 Homo sapiens 11-33 11710940-4 2001 To test this hypothesis, phospholipase C-gamma1 expression in human keratinocytes was reduced by transfecting the cells with an antisense phospholipase C-gamma1 construct and then evaluating the response of the keratinocyte differentiation markers involucrin and transglutaminase to 1,25-dihydroxyvitamin D3. Calcitriol 283-307 phospholipase C gamma 1 Homo sapiens 25-47 11710940-6 2001 Cotransfection of keratinocytes with the involucrin or transglutaminase promoter construct and the antisense phospholipase C-gamma1 construct showed decreased involucrin or transglutaminase promoter activity in response to 1,25-dihydroxyvitamin D3. Calcitriol 223-247 phospholipase C gamma 1 Homo sapiens 109-131 11710940-8 2001 The increase in keratinocyte intracellular free calcium and inositol triphosphate levels following 1,25-dihydroxyvitamin D3 administration were markedly reduced by the transfection of the antisense phospholipase C-gamma1 construct. Calcitriol 99-123 phospholipase C gamma 1 Homo sapiens 198-220 11710940-9 2001 These studies indicate that phospholipase C-gamma1 plays a critical role in the signal transduction pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differentiation at least in part by mediating the increase in inositol triphosphate production and intracellular calcium mobilization following 1,25-dihydroxyvitamin D3 administration. Calcitriol 118-142 phospholipase C gamma 1 Homo sapiens 28-50 11710940-9 2001 These studies indicate that phospholipase C-gamma1 plays a critical role in the signal transduction pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differentiation at least in part by mediating the increase in inositol triphosphate production and intracellular calcium mobilization following 1,25-dihydroxyvitamin D3 administration. Calcitriol 308-332 phospholipase C gamma 1 Homo sapiens 28-50 9579536-2 1998 Previous studies from our laboratory showed that phospholipase C-gamma1 (PLC-gamma1) was upregulated transcriptionally by 1,25(OH)2D3 in normal human keratinocytes, and a vitamin D responsive element (VDRE) in its promoter region has been identified. Calcitriol 122-133 phospholipase C gamma 1 Homo sapiens 49-71 9579536-2 1998 Previous studies from our laboratory showed that phospholipase C-gamma1 (PLC-gamma1) was upregulated transcriptionally by 1,25(OH)2D3 in normal human keratinocytes, and a vitamin D responsive element (VDRE) in its promoter region has been identified. Calcitriol 122-133 phospholipase C gamma 1 Homo sapiens 73-83 9579536-4 1998 The induction of the human PLC-gamma1 VDRE by 1,25(OH)2D3 was synergistic with all-trans retinoic acid in normal human keratinocytes, but none of the constructs was induced by 1,25(OH)2D3 and/or all-trans retinoic acid in SCC4 and SCC12B2 cells. Calcitriol 46-57 phospholipase C gamma 1 Homo sapiens 27-37