PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12019193-7 2002 S-Mephenytoin, a selective CYP2C19 inhibitor, inhibited 18-MC O-demethylation by 65% at a concentration of 2 times its K(I), and antibodies against rat 2C (human CYP2C8, 2C9, 2C19) inhibited 18-HC formation by 70%. Mephenytoin 0-13 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 162-168 9578596-3 1998 To that end, we purified CYP2C19, CYP2C9, and CYP2C8 from human liver samples using conventional chromatographic techniques and examined their capacity to oxidize S-mephenytoin, omeprazole, and tolbutamide. Mephenytoin 163-176 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 46-52 10901692-5 2000 S-mephenytoin (360 microM) activated DDS-NHY by human liver microsomes and by CYP2C8 by 43 +/- 36 and 193 +/- 16%, respectively. Mephenytoin 0-13 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 78-84