PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8867898-4 1996 Expression in Escherichia coli led to secretion in the periplasmic space of a fully bioactive hPRL variant constituting authentic hPRL with a peptide tag, i.e. Ala-Ser-(His)6-Ile-Glu-Gly-Arg, at its N-terminal. Arginine 187-190 prolactin Homo sapiens 94-98 8862501-0 1996 Effect of bromocriptine on insulin, growth hormone and prolactin responses to arginine in obesity. Arginine 78-86 prolactin Homo sapiens 55-64 7151830-0 1982 Prolactin response to arginine in children with hyperthyroidism and primary hypothyroidism. Arginine 22-30 prolactin Homo sapiens 0-9 7955444-2 1994 Arginine stimulates PRL secretion through pathways other than the activation of TRH receptors or dopamine-dependent mechanisms. Arginine 0-8 prolactin Homo sapiens 20-23 7955444-3 1994 We therefore investigated PRL responses to arginine in patients with hyperthyroidism. Arginine 43-51 prolactin Homo sapiens 26-29 7955444-9 1994 PRL responses to arginine, small but clearly detectable in normal men, were completely abolished in hyperthyroid men (peak PRL levels, 248 +/- 48 mU/l, vs 112 +/- 14, P < 0.01). Arginine 17-25 prolactin Homo sapiens 0-3 7955444-9 1994 PRL responses to arginine, small but clearly detectable in normal men, were completely abolished in hyperthyroid men (peak PRL levels, 248 +/- 48 mU/l, vs 112 +/- 14, P < 0.01). Arginine 17-25 prolactin Homo sapiens 123-126 7955444-10 1994 CONCLUSIONS: PRL responses to arginine are impaired in hyperthyroid patients. Arginine 30-38 prolactin Homo sapiens 13-16 7955444-11 1994 Therefore, arginine should be added to the list of PRL stimuli whose responses are blunted in hyperthyroidism. Arginine 11-19 prolactin Homo sapiens 51-54 3035002-7 1987 The TRH- and arginine-induced increases in prolactin and growth hormone were significantly greater after administration of naloxone (p less than 0.05). Arginine 13-21 prolactin Homo sapiens 43-52 4089188-0 1985 Effect of normal aging on the prolactin response to graded doses of sulpiride and to arginine. Arginine 85-93 prolactin Homo sapiens 30-39 6403444-7 1983 The rise in serum prolactin concentrations in response to arginine was unaffected by hyperglycaemia, whereas the TRH-induced release of prolactin was suppressed. Arginine 58-66 prolactin Homo sapiens 18-27 6403444-8 1983 Since arginine induces the release of growth hormone and prolactin via the hypothalamus, while TRH acts at the pituitary level, the glycaemic state appears to exert a modulatory effect on the secretion of growth hormone and prolactin in type II-diabetics at both locations. Arginine 6-14 prolactin Homo sapiens 57-66 6414103-7 1983 It is concluded 1) that even in hypophysectomized normoprolactinemic patients the circulating PRL may originate mainly from the residual tumor cells, and 2) that the sulpiride test is useful to detect the abnormalities of hypothalamo-pituitary axis in operated patients with PRL-secreting adenomas, whereas TRH, arginine, and L-dopa tests are less useful for such purposes. Arginine 312-320 prolactin Homo sapiens 94-97 7151830-1 1982 Plasma prolactin (PRL) response to arginine was examined in 16 prepubertal and 18 pubertal children with constitutional short stature, 5 patients with hyperthyroidism and 4 patients with primary hypothyroidism. Arginine 35-43 prolactin Homo sapiens 18-21 7151830-3 1982 Arginine infusion elicited significant (P less than 0.05) rises in plasma PRL in all groups. Arginine 0-8 prolactin Homo sapiens 74-77 7151830-4 1982 The maximal increment of plasma PRL above the baseline level after arginine stimulation was significantly larger (P less than 0.05) in pubertal than in prepubertal females and was significantly smaller (P less than 0.05) in patients with hyperthyroidism than in age- and sex-matched controls. Arginine 67-75 prolactin Homo sapiens 32-35 7151830-6 1982 These data suggest that arginine produces a significant increase in plasma PRL and the PRL response to arginine was greater in pubertal than in prepubertal children. Arginine 24-32 prolactin Homo sapiens 75-78 7151830-6 1982 These data suggest that arginine produces a significant increase in plasma PRL and the PRL response to arginine was greater in pubertal than in prepubertal children. Arginine 24-32 prolactin Homo sapiens 87-90 7151830-6 1982 These data suggest that arginine produces a significant increase in plasma PRL and the PRL response to arginine was greater in pubertal than in prepubertal children. Arginine 103-111 prolactin Homo sapiens 87-90 7151830-1 1982 Plasma prolactin (PRL) response to arginine was examined in 16 prepubertal and 18 pubertal children with constitutional short stature, 5 patients with hyperthyroidism and 4 patients with primary hypothyroidism. Arginine 35-43 prolactin Homo sapiens 7-16 7151830-7 1982 Plasma PRL response to arginine is suppressed in children with hyperthyroidism and the basal plasma PRL is markedly elevated in primary hypothyroidism. Arginine 23-31 prolactin Homo sapiens 7-10 6109991-0 1981 Effects of prosomatostatin on growth hormone and prolactin response to arginine in man. Arginine 71-79 prolactin Homo sapiens 49-58 6792262-1 1981 To investigate a possible hypothalamic alteration in obesity, we have studied the pattern of PRL secretion in response to insulin hypoglycemia, arginine infusion and TRH injection in 12 grossly obese patients and in 12 normal-weight controls. Arginine 144-152 prolactin Homo sapiens 93-96 6792262-2 1981 In the obese patients, PRL secretion was significantly lower than in normal subjects in response to insulin hypoglycemia and arginine infusion, while it was not significantly different from that in controls in response to TRH. Arginine 125-133 prolactin Homo sapiens 23-26 6785297-5 1981 Thus, the release of LH, FSH, TSH, and PRL in response to adequate acute stimuli at the pituitary level is not modulated by hyperglycemia in insulin-dependent diabetes, while arginine-induced GH release is suppressed. Arginine 175-183 prolactin Homo sapiens 39-42 852930-1 1977 The C-terminal undecapeptide of ovine prolactin, H-Leu-Asn-Cys-Arg-Ile-Ile-Try-Asn-Asn-Asn-Cys-OH possesses several structural features common to protein proteinase inhibitors, yet has no inhibitor properties. Arginine 63-66 prolactin Homo sapiens 38-47 474034-0 1979 Study on the reproducibility of human prolactin response to sulpiride, benserazide, insulin hypoglycaemia and arginine infusion. Arginine 110-118 prolactin Homo sapiens 38-47 425782-2 1979 A rise in both, Prl and GH with a maximal increment of 15.9 +/- 6.7 (SE) ng/ml, and 12.4 +/- 4.9 ng/ml above basal levels, respectively, (P less than 0.05) was observed after iv arginine. Arginine 178-186 prolactin Homo sapiens 16-19 110024-2 1978 The results are compared with the response of serum prolactin to arginine, insulin and TRH. Arginine 65-73 prolactin Homo sapiens 52-61 748015-1 1978 Arginine has been demonstrated to be a potent stimulus to GH and PRL secretion. Arginine 0-8 prolactin Homo sapiens 65-68 1236817-14 1975 Effect of arginine on the concentrations of serum hGH, hPRL and hCS during pregnancy. Arginine 10-18 prolactin Homo sapiens 55-59 1249182-0 1976 Prolactin response to arginine in normal subjects and in patients with hyperthyroidism. Arginine 22-30 prolactin Homo sapiens 0-9 1249182-1 1976 The effect of arginine on serum prolactin concentrations was studied in 18 normal subjects and in 7 patients with hyperthyroidism in normal subjects, arginine infusion produced an increase of serum prolactin at least 6 ng/ml from the baseline, and the mean peak level (25.2 +/- 3.3 ng/ml, mean +/- SE) was significantly higher than the basal level (8.6 +/- 5.2 ng/ml, P less than 0.001). Arginine 14-22 prolactin Homo sapiens 32-41 1249182-1 1976 The effect of arginine on serum prolactin concentrations was studied in 18 normal subjects and in 7 patients with hyperthyroidism in normal subjects, arginine infusion produced an increase of serum prolactin at least 6 ng/ml from the baseline, and the mean peak level (25.2 +/- 3.3 ng/ml, mean +/- SE) was significantly higher than the basal level (8.6 +/- 5.2 ng/ml, P less than 0.001). Arginine 150-158 prolactin Homo sapiens 198-207 1249182-4 1976 In hyperthyroid patients, the increment of serum prolactin after arginine infusion at 30 min (3.9 +/- 1.5 ng/ml) was significantly lower than that of the normal controls which were matched by age and sex (17.1 +/- 4.4 ng/ml, P less than 0.05). Arginine 65-73 prolactin Homo sapiens 49-58 1249182-5 1976 After treatment when these patients were euthyroid, the increment of prolactin after arginine infusion at 30 min was significantly increased (16.3 +/- 4.3 ng/ml, P less than 0.05) and had reached the level of control subjects. Arginine 85-93 prolactin Homo sapiens 69-78 1249182-6 1976 These data indicate that the prolactin response to arginine in hyperthyroidism is diminished. Arginine 51-59 prolactin Homo sapiens 29-38 1236817-18 1975 Effect of arginine on the concentrations of serum hGH and hPRL in puerperium. Arginine 10-18 prolactin Homo sapiens 58-62 24615730-13 2014 Our study implicates a critical role for the T/PRL-stimulated CPD-Arg-NO pathway in pCa progression, and suggests that AR+PRLR inhibition is a more effective treatment for pCa. Arginine 66-69 prolactin Homo sapiens 47-50 4478623-0 1974 [Proceedings: Arginine and synthesis and secretory functions of growth hormone and prolactin]. Arginine 14-22 prolactin Homo sapiens 83-92 4201417-0 1973 Prolactin and growth hormone release in response to sequential stimulation by arginine and synthetic TRF. Arginine 78-86 prolactin Homo sapiens 0-9 33047125-0 2020 Impact of arginine supplementation on serum prolactin and mRNA abundance of amino acid transporter genes in mammary tissue of lactating sows. Arginine 10-18 prolactin Homo sapiens 44-53 33047125-1 2020 This study was conducted to test the hypothesis that supplemental dietary Arg to late-pregnant and lactating sows increases serum prolactin concentrations and mRNA abundance of SLC7A1, SLC7A2 and SLC6A14 in mammary parenchymal tissue. Arginine 74-77 prolactin Homo sapiens 130-139 33047125-12 2020 Compared to controls, serum prolactin concentrations tended to be greater (P = 0.08) in ARG sows on d 4 of lactation, and did not differ on d 18. Arginine 88-91 prolactin Homo sapiens 28-37 33047125-14 2020 Dietary Arg supplementation at a rate of 0.10 g/kg BW during late pregnancy and lactation tended to increase serum prolactin concentrations with no increase in mammary transcript abundance of SLC7A1, SLC7A2 and SLC6A14 in early lactation. Arginine 8-11 prolactin Homo sapiens 115-124 10739497-0 2000 The effects of L-arginine on the release of prolactin from decidual explants in vitro. Arginine 15-25 prolactin Homo sapiens 44-53 21308737-2 2011 We have reported that L-arginine, released from extracellular substrates by prolactin (PRL)- and 17beta-estradiol (E2)-induced carboxypeptidase-D in the cell membrane, promotes nitric oxide (NO) production for MCF-7 cell survival. Arginine 22-32 prolactin Homo sapiens 87-90 18535109-15 2008 In summary, PRL/E2-induced cell-surface CPD released Arg from extracellular substrates, increased intracellular NO, promoted survival and inhibited apoptosis of MCF-7 cells. Arginine 53-56 prolactin Homo sapiens 12-15 11053497-3 2000 Arg exerts its vascular actions also through NO-independent effects, including membrane depolarization, syntheses of creatine, proline and polyamines, secretion of insulin, growth hormone, glucagon and prolactin, plasmin generation and fibrinogenolysis, superoxide scavenging and inhibition of leukocyte adhesion to nonendothelial matrix. Arginine 0-3 prolactin Homo sapiens 202-211 10739497-1 2000 OBJECTIVE: Our aim was to elucidate a role for the L -arginine-nitric oxide-cyclic guanosine monophosphate pathway in the control of decidual prolactin release in vitro. Arginine 51-62 prolactin Homo sapiens 142-151 10739497-3 2000 RESULTS: L -arginine, at 100 micromol/L, produced an increase in medium prolactin concentration after a 2-hour exposure; however, its inactive isomer, D -arginine, at the same concentration, did not. Arginine 9-20 prolactin Homo sapiens 72-81 10739497-4 2000 The increase in prolactin release initiated by L -arginine was sustained after a 24-hour incubation. Arginine 47-58 prolactin Homo sapiens 16-25 10739497-8 2000 CONCLUSIONS: These results suggest that the L -arginine-nitric oxide-cyclic guanosine monophosphate pathway is involved in the regulation of prolactin secretion by decidual tissue. Arginine 44-55 prolactin Homo sapiens 141-150 9202399-11 1997 The inhibition of PRL and GH release by IFN-gamma was markedly reduced in L-arginine-depleted medium. Arginine 74-84 prolactin Homo sapiens 18-21