PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11338505-10	2001	The mutation results in substitution of cysteine amino acid residue in the cysteine-rich extracellular domain of protein kinase encoded by the gene RET for arginine.	Arginine	156-164	ret proto-oncogene	Homo sapiens	148-151	
26572832-10	2016	CONCLUSIONS: In codon 634, arginine substitutions for cysteine may cause slightly higher penetrance rates of MEN 2A which, overall, are too small to treat carriers differently.	Arginine	27-35	ret proto-oncogene	Homo sapiens	109-115	
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	158-161	ret proto-oncogene	Homo sapiens	84-87	
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	158-161	ret proto-oncogene	Homo sapiens	109-112	
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	84-87	
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	109-112	
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	84-87	
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	109-112	
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	84-87	
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	109-112	
11316186-8	2001	A homozygous missense mutation (CGG-to-TGG) at RET codon 969 was identified in this patient, which resulted in an amino acid change from arginine to tryptophan.	Arginine	137-145	ret proto-oncogene	Homo sapiens	47-50	
11386462-0	2001	A family of multiple endocrine neoplasia type 2A with the RET proto-oncogene mutation in codon 618 (Cys-->Arg).	Arginine	109-112	ret proto-oncogene	Homo sapiens	58-61	
11386462-3	2001	We report here three generations of one MEN-2 family with rare missense mutation at codon 618 (Cys-->Arg) of the RET proto-oncogene.	Arginine	104-107	ret proto-oncogene	Homo sapiens	116-119	
9018112-4	1997	In this study, we have introduced a MEN 2A mutation (Cys634-->Arg) and the unique MEN 2B mutation (Met918-->Thr) in two RET isoforms of 1114 and 1072 amino acids which differ in the carboxy-terminus part.	Arginine	65-68	ret proto-oncogene	Homo sapiens	126-129	
9539934-4	1998	RESULTS: A heterozygote T-->C (Cys-->Arg) mutation at codon 618 in exon 10 of the RET proto-oncogene was identified in 4 family members who had previously been diagnosed with medullary thyroid cancer.	Arginine	43-46	ret proto-oncogene	Homo sapiens	88-91	
9589057-6	1998	Genetic testing for ret protooncogene mutation revealed a point mutation at codon 634 (Cys-->Arg) in exon 11.	Arginine	96-99	ret proto-oncogene	Homo sapiens	20-23	
9097963-6	1997	Genetic analysis revealed the presence of an unusual heterozygous mutation in exon 11 of the RET proto-oncogene representing a duplication of 12 bp resulting in the insertion of four amino acids between codon 634 (Cys) and 635 (Arg), thus creating an additional cysteine residue.	Arginine	228-231	ret proto-oncogene	Homo sapiens	93-96	
7889627-8	1995	RESULTS: A heterozygous TGC to CGC mutation of codon 634 (cysteine to arginine) was found in the PHAEO and medullary thyroid cancer from the MEN 2A patient.	Arginine	70-78	ret proto-oncogene	Homo sapiens	141-147	
8909322-4	1996	RESULTS: One of these kindred"s carried both Hirschsprung"s disease and MEN 2A in conjunction with a cysteine-to-arginine substitution of codon 620 of the RET gene.	Arginine	113-121	ret proto-oncogene	Homo sapiens	155-158	
7495285-6	1995	Six MEN-2A-associated hyperplastic glands exhibited identical band shifts in the polymerase chain reaction single-strand conformation polymorphism analysis of exon 11, which corresponded to a Cys 634-->Arg substitution in the nucleotide sequence analysis (TGC-->CGC), whereas in the MEN 2B parathyroid specimen a point mutation was found at codon 918 of exon 16 (ATG-->ACG), causing a Met 918-->Thr substitution.	Arginine	205-208	ret proto-oncogene	Homo sapiens	4-10	
7495285-8	1995	Furthermore, our results are in accordance with the observation that MEN 2A patients with Cys 634-->Arg (germline) mutations have a higher risk of developing parathyroid disease than those with other mutations at codon 634.	Arginine	103-106	ret proto-oncogene	Homo sapiens	69-75	
8765374-4	1996	Ten different types of mutations were identified in the MEN 2A/FMTC families (620 Cys-->Arg, 618 Cys-->Ser, Gly, 611 Cys-->Tyr; 634 Cys-->Arg, Tyr, Trp, Phe, Ser, Gly) and all 6 MEN 2B families had a 918 Met-->Thr point mutation.	Arginine	91-94	ret proto-oncogene	Homo sapiens	56-62	
8783101-6	1996	The DNA sequence of the PCR products from clinically established MEN 2A patients showed a mutation at codon 634 (TGC-->CGC) that resulted in an amino acid change from cysteine to arginine.	Arginine	182-190	ret proto-oncogene	Homo sapiens	65-71	
7881414-6	1994	In three families, both HSCR and MEN 2A were associated with a single Cys-->Arg mutation at either codon 618 or 620 of RET.	Arginine	76-79	ret proto-oncogene	Homo sapiens	33-39	
7881414-6	1994	In three families, both HSCR and MEN 2A were associated with a single Cys-->Arg mutation at either codon 618 or 620 of RET.	Arginine	76-79	ret proto-oncogene	Homo sapiens	119-122	
7849700-3	1994	We have recently shown an unexpected correlation between one particular RET mutation, cys634-->arg, and the probability of parathyroid involvement in families with MEN 2A.	Arginine	98-101	ret proto-oncogene	Homo sapiens	72-75	
7849700-3	1994	We have recently shown an unexpected correlation between one particular RET mutation, cys634-->arg, and the probability of parathyroid involvement in families with MEN 2A.	Arginine	98-101	ret proto-oncogene	Homo sapiens	167-173